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    Does brain shrinkage lead to dementia?

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    • MauritioM
      Mauritio @DavidPS
      last edited by

      @DavidPS said in Does brain shrinkage lead to dementia?:

      One strategy for slowing loss of brain structure is to reduce your homocysteine

      What I dont understand is how. methionine restriction can be so healthy (also for the brain). when it causes hyperhomocysteinemia....

      Dare to think.

      My X:
      x.com/Metabolicmonstr

      DavidPSD 1 Reply Last reply Reply Quote 0
      • DavidPSD
        DavidPS @Mauritio
        last edited by DavidPS

        @Mauritio - Homocysteine (Hcy) is an amino acid and it is strongly correlated with dementia (both Parkinson’s disease (PD) and Alzheimer’s disease (AD) ) and vascular disease including stroke. The metabolism of Hcy is linked to that of several vitamins—especially folate, B6, and B12. Concentrations of homocysteine can be inexpensively and safely lowered by treatment with a combination of these B vitamins.

        154667b6-060f-421b-b4de-a4a9a7612695-image.png
        (see source)

        Homocysteine and Parkinson's disease (2023)

        Association analyses of nutritional markers with Parkinson’s disease and Alzheimer’s disease (2024)

        Homocysteine and Alzheimer's disease (2003)

        Homocysteine as a predictor of cognitive decline in Alzheimer’s disease (2010)

        Homocysteine, vitamins, and vascular disease prevention (2007)

        ““Effective health care depends on self-care” - Ivan Illich, 👀
        ☂️

        MauritioM 1 Reply Last reply Reply Quote 0
        • MauritioM
          Mauritio @DavidPS
          last edited by

          @DavidPS I know. But that doesn't really answer the issue I brought up...

          Dare to think.

          My X:
          x.com/Metabolicmonstr

          LucHL 1 Reply Last reply Reply Quote 0
          • LucHL
            LucH @Mauritio
            last edited by LucH

            @Mauritio said in Does brain shrinkage lead to dementia?:

            But that doesn't really answer the issue I brought up...

            We need tryptophan to form B3 when lacking.
            Once again, it's a question of proportions. Why?
            Note: Tryptophan has limited access to the brain, sometimes leading to migraines. See details below.

            No need to use B3 for lowering Homocysteine if we bring enough B6. But B6 is exhausted if we suffer from low inflammation grade (like arthrosis). See the brol! (local expression inducing havoc).
            Note: Homocysteine levels go up as methyl donors get used up. Idem when following HD B3.
            => 500 mg TMG 2x/d when required.

            Additional info:
            Tryptophan
            Tryptophan has limited access to the brain, thus sometimes the cause leading to migraines.
            Tryptophan must share the transport to brain with five other amino acids: tyrosine, phenylalanine, valine, leucine and isoleucine. So, for example, an excess or deficiency of tyrosine will inhibit the passage of tryptophan.

            See too:
            https://raypeat.com/articles/articles/gelatin.shtml
            Both tryptophan and cysteine inhibit thyroid function and mitochondrial energy production, and have other effects that decrease the ability to withstand stress. Tryptophan is the precursor to serotonin, which causes inflammation, immunodepression, and generally the same changes seen in aging. Histidine is another amino acid precursor to a mediator of inflammation, histamine; would the restriction of histidine in the diet have a longevity promoting effect, too?

            MauritioM DavidPSD 2 Replies Last reply Reply Quote 0
            • MauritioM
              Mauritio @LucH
              last edited by

              @LucH said in Does brain shrinkage lead to dementia?:

              @Mauritio said in Does brain shrinkage lead to dementia?:

              But that doesn't really answer the issue I brought up...

              We need tryptophan to form B3 when lacking.
              Once again, it's a question of proportions. Why?
              Note: Tryptophan has limited access to the brain, sometimes leading to migraines. See details below.

              No need to use B3 for lowering Homocysteine if we bring enough B6. But B6 is exhausted if we suffer from low inflammation grade (like arthrosis). See the brol! (local expression inducing havoc).
              Note: Homocysteine levels go up as methyl donors get used up. Idem when following HD B3.
              => 500 mg TMG 2x/d when required.

              Additional info:
              Tryptophan
              Tryptophan has limited access to the brain, thus sometimes the cause leading to migraines.
              Tryptophan must share the transport to brain with five other amino acids: tyrosine, phenylalanine, valine, leucine and isoleucine. So, for example, an excess or deficiency of tyrosine will inhibit the passage of tryptophan.

              See too:
              https://raypeat.com/articles/articles/gelatin.shtml
              Both tryptophan and cysteine inhibit thyroid function and mitochondrial energy production, and have other effects that decrease the ability to withstand stress. Tryptophan is the precursor to serotonin, which causes inflammation, immunodepression, and generally the same changes seen in aging. Histidine is another amino acid precursor to a mediator of inflammation, histamine; would the restriction of histidine in the diet have a longevity promoting effect, too?

              That answers my question even less lol ... I give up .

              Dare to think.

              My X:
              x.com/Metabolicmonstr

              DavidPSD 1 Reply Last reply Reply Quote 0
              • DavidPSD
                DavidPS @LucH
                last edited by

                @LucH - Thanks for your reply. I am here to learn as well as help. It seems that you are always connecting dots that I failed to consider.

                ““Effective health care depends on self-care” - Ivan Illich, 👀
                ☂️

                1 Reply Last reply Reply Quote 0
                • DavidPSD
                  DavidPS @Mauritio
                  last edited by DavidPS

                  @Mauritio This is a https://dictionary.cambridge.org/dictionary/english/connect-the-dotsing area. Perhaps this will help.

                  Hyperhomocysteinemia and Disease—Is 10 μmol/L a Suitable New Threshold Limit? (2024)

                  70a0abb1-fe3f-43d8-80ea-1c5f90a74e2b-image.png

                  ““Effective health care depends on self-care” - Ivan Illich, 👀
                  ☂️

                  1 Reply Last reply Reply Quote 0
                  • LucHL
                    LucH
                    last edited by

                    @DavidPS
                    Thanks for comment.

                    Here is some more information to help connecting the dots ...
                    Serotonin and Mood
                    Is serotonin a booster or a downer?

                    Serotonin is a central nervous system (CNS) neurotransmitter secreted by a group of neurons called serotonergic neurons. Serotonin is one of the monoamines which are particularly involved in the regulation of states of alertness and mood. We often see that people with unstable moods, depression, are deficient in hormonal secretion, with an impact on emotions, appetite, sleep, temporary aggressiveness, etc.
                    Serotonin fulfills many other metabolic functions, such as thermoregulation (cold extremities), pain control (anti-inflammatory), eating behavior (satiety), sexual desire, memory, etc. (1)
                    What effect can serotonin have on humans?
                    In addition to these biological functions, the effects of serotonin on our mind should not be taken lightly (regulation of emotions), in more sensitive or more fragile people. (…)
                    Is serotonin a booster or a downer?
                    “By increasing extracellular serotonin, SSRIs disrupt energy homeostasis and often worsen symptoms during acute treatment. The science behind many anti-depressant medications appears to be backwards.” (3) (…)
                    Useful nutrients
                    To rebalance serotonergic function, it is necessary to combine:

                    • Vitamin B6 which participates in the synthesis of serotonin;
                    • Vitamin B3 (niacinamide, not niacin) which promotes the cerebral metabolism of tryptophan at the expense of its hepatic metabolism (i.e. produced via the liver);
                    • Magnesium to reduce stress, and which also has an anti-water retention effect;
                      NB1: A dose of Mg and B6 will therefore be welcome with the sweet snack at 5 p.m.
                      Parenthesis: We often recommend eating a banana, a square of chocolate or a few pieces of coconut, or even oilseeds, as a 4-5 p.m. snack because these foods are naturally rich in tryptophan, the precursor of serotonin. OK, but let's try to understand the process.
                      …
                      To be continued on this link (In French, with links in English; translator needed).
                      https://mirzoune-ciboulette.forumactif.org/t1829-la-serotonine-comme-booster-ou-downer#25014
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                    • DavidPSD
                      DavidPS
                      last edited by

                      There is more than one way to shrink a brain:
                      .

                      1. Alcohol Use Disorder and Dementia: A Review (2024)

                      2. Obesity and aging: consequences for cognition, brain structure, and brain function (2015)

                      3. Association between Type 2 Diabetes Mellitus and Brain Atrophy: A Meta-Analysis (2022)

                      4. Effects of sleep deprivation on brain atrophy in individuals with mild cognitive impairment and Alzheimer's disease (2024)

                      ““Effective health care depends on self-care” - Ivan Illich, 👀
                      ☂️

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                      • DavidPSD
                        DavidPS
                        last edited by

                        Visceral and Subcutaneous Abdominal Fat Predict Brain Volume Loss at Midlife in 10,001 Individuals (2024)

                        ““Effective health care depends on self-care” - Ivan Illich, 👀
                        ☂️

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