Gastrointestinal hormone-mediated beneficial bioactivities of bitter polyphenols

DavidPS

Dietary polyphenols have beneficial effects on obesity and diabetes by regulating gut hormones such as GLP-1.

Top sources of these polyphenols: coffee, tea, chocolate, and red wine.

Gastrointestinal hormone-mediated beneficial bioactivities of bitter polyphenols (2024)

LucH

Hi,
Yes, indeed. I do take some kinds of polyphenols, but in cure when supplementing.
Why, besides beneficial effects (eye, allergies, microbiome, etc.) you have to take into account the possible effects on the pathway CyP450, a detox pathway through the kidneys. It dampens / slows down the way-out of toxins and accumulation could take place.

Polyphenols inhibit CyP450 detox enzyme
Resveratrol & Quercetin
All studies seem to agree that resveratrol, curcumin, quercetin and bioperine (from pepper) are potent inhibitors of CyP450.
CyP450 is well-known to be involved in drug metabolism (detox enzyme through liver), but also in …
So resveratrol and quercetin inhibit detox, if taken in a repetitive way. OK in cure.
http://www.longecity.org/forum/topic/40417-resveratrol-curcumin-quercetin-bioperine/

Table Drugs & CyP450 interference
http://www.anaesthetist.com/physiol/basics/metabol/cyp/Findex.htm

Link for Google search : potent inhibitors for P450
Resveratrol
http://www.google.com/search?hl=en&q=resveratrol+P450+potent+inhibit&aq=f&aqi=&aql=&oq=&gs_rfai=
 resveratrol P450 potent inhibit
http://www.google.com/search?hl=en&q=Resveratrol+P450+potent+inhibitor&btnG=Search&aq=f&aqi=&aql=&oq=&gs_rfai=
 Resveratrol P450 potent inhibitor

Curcumin
http://www.google.com/search?hl=en&q=Curcumin+P450+potent+inhibit&aq=f&aqi=&aql=&oq=&gs_rfai=
 Curcumin P450 potent inhibit
http://www.google.com/search?hl=en&q=Curcumin+P450+potent+inhibitor&aq=f&aqi=&aql=&oq=&gs_rfai=
 Curcumin P450 potent inhibitor

Quercetin
http://www.google.com/search?hl=en&q=quercetin+P450+inhibit&aq=f&aqi=&aql=&oq=&gs_rfai=
 Quercetin P450 potent inhibit

http://www.google.com/search?hl=en&q=Quercetin+P450+potent+inhibitor&btnG=Search&aq=f&aqi=&aql=&oq=&gs_rfai=
 Quercetin P450 potent inhibitor

Piperine (=> Bioperine)
http://www.google.com/search?hl=en&q=piperine+P450+inhibit&aq=f&aqi=&aql=&oq=&gs_rfai=
 Piperine P450 inhibit
http://www.google.com/search?hl=en&q=bioperine+P450+potent+inhibit&aq=f&aqi=&aql=&oq=&gs_rfai=
 Piperine P450 inhibitor

Mauritio

Olive polyphenols are pretty underrated IMO.

https://bioenergetic.forum/topic/3624/olive-leaf-extract-increases-t3-t4-lowers-tsh