Random, interesting studies
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Phytol
Phytol lowers weight gain on a HFD. Drastically increases UCP1 (by 10x in white adipose tissue!), PGC1a and AMPK. It also strongly increases the most important enzyme for glucose oxidation, Pyruvate dehydrogenase (PDH).
https://sci-hub.ren/10.1039/C7FO01817G"...PHY efficiently interacts with COX-1 and 2, NF-κB, and IL-1β. In conclusion, PHY exhibits anti-inflammatory activity, possibly via COX-1 and 2, NF-κB, and IL-1β dependent pathways."
https://pubmed.ncbi.nlm.nih.gov/32583784/Phytol, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects
https://pubmed.ncbi.nlm.nih.gov/32091204/Phytol seems to be a GABA-A receptor agonist, lengthening sleep time
https://pubmed.ncbi.nlm.nih.gov/39357640/Again, it binds to GABA-A receptor, but also to 5HT1A. Not sure if it agonizes or antagonizes it.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11926570/Phytol drastically inhibits gastric ulcers
https://pubmed.ncbi.nlm.nih.gov/38717706/Could be a dopamine d2 antagonist based on its antiemetic properties. But could also be due to possible 5ht3 antagonism (similar to ondansetron) .
https://pmc.ncbi.nlm.nih.gov/articles/PMC10008523/ -
Lemon balm / Melissa
Anti-estrogenic:
anti-cancer effect against breast cancer . Most effective against estrogen sensitive breast cancer.
https://pubmed.ncbi.nlm.nih.gov/32351599/It decreases the severity of dismenorrhea, again pointing towards an anti-estrogen effect.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6447884/Decreases symptoms of PMS.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4557408/Anti- prolactin/Anti-TSH:
https://pubmed.ncbi.nlm.nih.gov/7202226/
Lowers weight gain on a HFD. Lowers FFAs and triglycerides.
https://sci-hub.ren/10.1016/j.jep.2020.113360 -
Androgenic and aphrodesiac action of the medicinal plant Lithospermum Arvense (bird millet)
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@Mauritio wow nice! And Lemon Balm is super easy to grow perennial herb. Available in most garden stores. Smells great too!
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@Mauritio do you mess around with any phytol these days? Food or extract… is there a supplement phytol? Or just load up on the skins of nuts and slam seaweeds?
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@dapose said in Random, interesting studies:
And Lemon Balm is super easy to grow perennial herb. Available in most garden stores. Smells great too!
Yes. And I haven't even posted all the cool studies on it . There's more for dopamine, liver health and as an anti-viral.
I've been taking lemon balm extract for over a week. And i finally feel like I'm not about to catch a cold for the first time this winter. It's also very calming and seems to help weight loss. Seems to lower blood sugar noticably. -
@dapose said in Random, interesting studies:
do you mess around with any phytol these days? Food or extract…
Ive ordered a food grade phytol supplement from Spain. Some herb, weed or terpene shops carry it.
I'm looking forward to trying it.Im kinda trying to recreate the 1/2nd generation Gonadin.I already take Diosgenin, now phytol . Next methyl oleate (might be able to accelerate PUFA detox).
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Rose hip
Rose hip increases thermogenesis, browning of white adipose tissue and UCP1 (a lot)
https://pubmed.ncbi.nlm.nih.gov/27980600/Rose hip extract lowers weight gain on a HFD, lowers visceral and liver fat.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3892499/It reduces atherosclerosis,oxidized LDL, total cholesterol and fibrinogen.
https://pubmed.ncbi.nlm.nih.gov/28399420/Daily intake of rosehip extract decreases abdominal visceral fat in preobese subjects
https://pmc.ncbi.nlm.nih.gov/articles/PMC4358417/#sec15 -
@Mauritio
From Wikipedia, the free encyclopedia
Phytoprogestogens, also known as phytoprogestins, are phytochemicals (that is, naturally occurring, plant-derived chemicals) with progestogenic effects.[1][2]Relative to their phytoestrogen counterparts, phytoprogestogens are rare.[1] However, a number have been identified, including kaempferol, diosgenin (found in yam), apigenin (found in chasteberry),[1][3] naringenin, and syringic acid, among others.[2] In addition, 3,8-dihydrodiligustilide from Ligusticum chuanxiong is a potent progestogen (EC50 = 90 nM), whereas riligustilide is a weak progestogen (EC50 ≈ 81 μM).[4][5]
carrot salad by R.Peat delivers apigenin (phytoprogestogen) and absorbs estrogens
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1359176/full
" In mice, NAD+ levels can be elevated via treatment with apigenin, a natural flavonoid that inhibits the NAD+-consuming glycoprotein CD38."
Progesteron synthesis depends on NAD as a cofactor as well as myo-inositol synthase . -
@cedric said in Random, interesting studies:
From Wikipedia, the free encyclopedia
Phytoprogestogens, also known as phytoprogestins, are phytochemicals (that is, naturally occurring, plant-derived chemicals) with progestogenic effects.[1][2]Yes I have posted this very paragraph in this thread before. Not sure how strong Diosgenins progestogenic effects are, it feels more androgenic.
I have posted about syringic acid and the Chinese herb progestogen as well.
