@questforhealth said in Anyone with Ehlers Danlos and chronic pain flare ups find a solution?:

Thiamine need is driven by heavy metals

Treating symptoms with thiamine is allopathic thinking

What do you mean by that?

Multiple things cause problems with thiamine function and multiple things exacerbate thiamine deficiency. It is a complicated topic.

Hiding in Plain Sight: Modern Thiamine Deficiency

Cell damage through pentose phosphate pathway in fetus fibroblast cells exposed to methyl mercury

Fatty acid signatures connect thiamine deficiency with the diet of the Atlantic salmon (Salmo salar) feeding in the Baltic Sea This one shows that PUFA (causes oxidative stress) causes thiamine deficiency in spawning salmon. Adding thiamine to the water saved the salmon egg hatch.

My own mercury toxicity exacerbated my thiamine deficiency. Mercury causes high oxidative stress. Thiamine quenches oxidative stress. But continuously high oxidative stress can use up the available thiamine, causing deficiency. So high dose thiamine hcl has been extremely helpful for me. Since there is no safe way to get rid of the mercury, it seems to me that addressing the thiamine issue is a positive thing to do.