vitamin A-tocopherol antagonism
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is vitamin A even a concern if one can just take vitamin E? Taking vitamin E will destroy vitamin A right? (and the other fat solubles but we’re talking about A).
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@winters2 said in vitamin A-tocopherol antagonism:
Taking vitamin E will destroy vitamin A right
No. And forget what you read elsewhere, particularly on old RPF. He smoked the carpet!
If you moderate the intake retinol (maxi 10 000 UI or 3 000 mcg once a week), you won't get any problem.
I take mine once a week in the morning with fat, followed by vit D3 at the next meal.
So, not to be taken at the same time.
NB: A high dose could leave quinone. To avoid.Useful info (in French, translator needed).
De quelle quantité de lipides avons-nous besoin pour absorber les vitamines A D E K ?
http://suppversity.blogspot.be/2014/05/vitamin-d-e-k-how-much-and-what-type-of.html
=> Vitamin A, D, E & K - How Much and What Type of Fat Do You Need to Absorb These Fat Soluble Vitamins?You'd better take into account the interaction with vitamin K2.
We can convert K1 (from greens) into K2 (from animal source) but it is random and notoriously insufficient.
K2 plays a key role in the activation of hormones that regulate calcium metabolism: osteocalcin, which is involved in the mineralization of bone matrix, and matrix Gla protein (MGP), which protects soft tissues against calcification.
The role of vitamin K2 is not limited to these functions alone. Here, it is much more than a co-factor because vitamin K2 is the substance that allows dependent proteins A and D to be activated/come to life. While vitamins A and D act as signaling molecules, telling cells to produce certain proteins, vitamin K2 activates these proteins, giving them the physical ability to bind calcium. -
Vitamin A according to Chris Masterjohn
“Keep retinol to no more than 3,000 IU per day or 10,000 IU twice a week unless you have deficiency symptoms that only go away at higher doses. If you supplement with more, include supplement of vitamins D, E and K.”
Source: Harnessing the Power of Nutrients – Chris Masterjohn. 2022Monitoring your vitamin A status
https://www.youtube.com/watch?v=tZY0OCBNwtw
Need for:
Eye vision (night vision) and integrity (hyperkeratosis)
Skin (acne, hair follicles or bumps on your skin)
Immunity
Probably Kidney stones, circadian rhythm.
Immune intolerance: asthma, food intolerances
Low sex hormones
If you get one of these problems, it doesn’t mean vitamin is responsible but it could be one of the possibilities. We need zinc to metabolize vitamin A.10 000 UI a day (or 3 000 mcg)
RP says to adjust the amount of vit A to the thyroid status, how you metabolize. Too much could interfere with adrenal functions.
https://www.youtube.com/watch?v=_AEW8CiPXuw
Your metabolic rate determines how much vitamin A you need. According to Dr. Ray Peat, the higher your thyroid function the more vitamin A your body needs. On the contrary, if you have low thyroid function using too much vitamin A, can suppress your metabolism further.Note:
If 10 000 UI retinol => between 2500 and 3000 Vit D3.
I won't take more than 2 000 Ui vit D3 without K2. -
Some more information why / when high dose vit E could interfere ...
Vitamin K uses the same pathway as Vit E
Does vitamin K supplementation deplete vitamin E?
Mito says:
https://raypeatforum.com/community/threads/does-vitamin-k-supplementation-deplete-vitamin-e.39564/post-622839
There are several aspects of vitamin K’s biochemistry that suggest high doses vitamin K could have adverse effects on our health:
• Vitamins E and K are broken down in similar pathways (Shearer, 2008). High doses of either one elicit an increase in these catabolic pathways by activating a common receptor known as the steroid and xenobiotic receptor (SXR) or the pregnane X receptor (PXR). As a result, high doses of one will elicit the destruction of the other. Thus, high-dose vitamin K could contribute to vitamin E deficiency.
• Second, a small portion of vitamin K is broken down to a compound known as menadione (Thijssen, 2006). Some of the menadione is used to synthesize MK-4, but high concentrations are toxic. We therefore conjugate a portion of the menadione to glutathione, the master antioxidant and detoxifier of the cell, and excrete the complex into our urine. High doses of vitamin K could therefore deplete glutathione. This would impair detoxification, and along with vitamin E depletion it would hurt antioxidant activity.
• High doses of vitamin K can inhibit bone resorption, which is probably the mechanistic basis by which 45 mg/day reduce fracture risk (Iwamoto, 2013). While bone resorption sounds like a bad thing, we need to use it every day to help our bones remodel themselves and adapt their structures to our lifestyles, and to keep blood levels of calcium within a precisely controlled range. We also use bone resorption to release osteocalcin into the blood, where it acts on multiple tissues to improve our metabolic and hormonal health (Ferron, 2007; Oury, 2013). Ironically, one of the benefits of vitamin K2 is to support proper production of osteocalcin, but high doses of the vitamin could hypothetically prevent us from using it. That would be expected to hurt blood sugar control, insulin sensitivity, our metabolic rate, and, in males, testosterone production.
https://chrismasterjohnphd.com/blog/2016/12/09/the-ultimate-vitamin-k2-resource
