Tianeptine
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@iHateTheBlacks Amitriptiline is a SNRI. Please never respond to my threads again.
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@thyroidchor27 you're completely wrong here bud.
It's one google search away.
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@Bleach_Africa
"Amitriptyline acts primarily as a serotonin-norepinephrine reuptake inhibitor, with strong actions on the serotonin transporter and moderate effects on the norepinephrine transporter . It has negligible influence on the dopamine transporter and therefore does not affect the reuptake of dopamine , being almost 1000 times weaker than serotonin on it. It is metabolized into nortriptyline , a potent and selective norepinephrine reuptake inhibitor , which can complement its effects on norepinephrine reuptake."
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@Bleach_Africa said in Tianeptine is the most wonderful drug Ive tried:
I've withdrawn from just about every drug. Tianeptine Sulfate withdrawal after just 10 days was by far the most traumatic withdrawal I've ever had. I had Kratom, gabapentin, and clonazepam to help ease me through the withdrawal. For 9 days I laid in bed. The first 5 days I was crying for no reason, sweating, pooping out acid.
I've withdrawn from hardcore benzo usage after 6 years, and that was much milder (though much longer) than Tianeptine Sodium withdrawal, and I had tons of other things to help ease and get me through Tianeptine Sodium withdrawal and NOTHING to ease me through a 6 year 6mg a day
Did you stick to the 10 mg x 2 per day dosing on tianeptine sodium? Cause I know of 0 people who have had any sides on that dosage except perhaps insomnia, constipation and a general worsening of mood. People who get these withdrawals take it recreationally at 1g plus. These people are mentally ill. Even going above 30 mg is asking for trouble, like I said it has a narrow safety profile and if you arent down with that then dont do it lol
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@thyroidchor27 of course I didn't, I was very mentally ill and it was just a great way to pass the time during the quarantine.
It can easily give you an ulcer as well, at the end day 6 of my binge I had a sharp pain in my stomach that went away about 2 weeks after I quit.
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Ssecond time trying it without selegiline and all the sides avoided. The MAO I was definitely interacting somehow with it causing me chest pains.
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@thyroidchor27 have u been continuing?
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Not on the days where I take a microdose of selegiline in the morning, the MAO I somehow greatly prolongs the effect of the tianeptine sodium and although im not complaining about the effects, this prolongation causes insomnia,
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There are slightly looser stools due to the opiate effect.
Barring these two, its a God tier drug. Very underrated in the Peat sphere, although narrow therapeutic potential. Never go above 12.5 mg, and Imo just dosing 6 mg twice a day is probably enough because the binding affinity is very high for this drug for all sero, dopa, and mu opiod receptor.
I think just a month on it every other day will be great. But should be discontinued, and resumed every 5 months or so if the need arises. Great for when stuck in a dull routine, for enjoying movies, opening up perspectives, increasing socialisation experiences, mood lift etc etc, basically all the high sero / low dopamine expereinces. And although opiods are not Peaty, I think this combination is great for immediate mood lifts which while low sero also encourages is potentiated by the slight MOR agonism.
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@thyroidchor27 I often suggest people take 25mg twice a day for depression and it works very well with no side effects that I've noticed at all.
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I really liked Tianeptine but when I did a blood test my testosterone was HALF of my levels when sober. From 700 to 350. Went back to normal after I quit.
Also, I don't agree with the withdrawal scares in this thread. If you take the usually prescribed dosage of 3x 12.5mg a day, you will not have strong withdrawals at all.
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@deliciousowl yes its opiod. I think even that is too much I never go above 12 mg a day and I only use it three times a week. serotonin is generally androgen inhibitory and I dont think the opiod agonism outweighs the pro sero- inhibitors effects on T at that dose
