Is this Retarded? A Proposed Forced Oxidative Metabolism Steroid Cycle for an Obese Female.
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I posted this on Reddit too, but I’m curious about y’all thoughts on this as well.
I'm contemplating going full nuclear and would like any and all input on exactly how dumb this idea is.
Stats: Female, 250lbs, 5'5, 30 yrs old
Some background: You don't care about my life story but to give some context earlier this year I got out of an extremely stressful work environment (politics). I worked in that environment for close to 7 years. Over that time, I managed to put on a whopping 100 pounds of excess bodyweight. I was in extreme stress, all the time. My diet was horrible as I had so little time away from work that I basically lived off of fast food and garbage.
After getting a new (and much calmer) job earlier this year, I realized exactly how much damage I had done to myself. I understand I could have not let it get as bad as it did, but the reality is that I did, and all i can do now is mitigate that damage.
Last year, while still under large loads of stress, I attempted a mild cycle with a GLP-1 (Name brand Ozempic) I succeeded in losing about 50 pounds. When I left my previous job I lost my health benefits, and came off the Ozempic. I chose not to continue as I couldn't afford it, but also because I experienced some pretty nasty side effects and wanted to come off of it and see how I felt (which turned out to be significantly better). At the time of taking Ozempic, I didn't realize how severely it impacted me, mostly notably with the gut motility. I would go days without a bowel movement, had very little energy and started losing a pretty significant amount of hair.
With some time in-between jobs in the spring I picked back up some of my old interests, Mild weight lifting (just at home, dumbbells and resistance bands/x3 bar) and got into seriously attempting to integrate things from reading peats work. I'd been in the aura of Peat since like 2019, but never seriously tried implementing things, based on peats words and no one else, until this year.
Needless to say, I don't really want to try another GLP class drug. The metabolic consequences are too high for me now.
In that time I've experimented with:
• thyroid: dialed in a dose i feel great on (T3 only therapy at a relatively high dose -- about 88ug daily, take that number with a mild grain of salt as I use Tyronene and I know some doubt its potency). I've been on this dose for a month and a half now, temps are good pulse is good. I've been pretty consistently at 36.5C in the morning now since finding this dose. I feel happier, more energized, have the mental capacity to research again, and feel like any and all brain fog I had is completely gone.
• Progesterone (Progest-e): huge needle mover for me in terms of general calm and stress relief. When I started taking it I could legitimately feel the stress melting away. I started pretty high dose, like just multiple big globs under the tongue per day (maybe ~100mg?) and now take what i estimate to be about 30mg daily, cycled based on my period. A must try for females, in my opinion.
• High-Dose thiamine: worked up to ~500mg benfo. Feel it for sure. Makes me warmer. I'm keen to try TTFD next. Worth keeping in, but Now have gone through a few bottle I usually wait a few weeks before ordering another bottle to bring it back in.
• Supplemental D,E,K: Basic, simple, easy, i feel no real difference but worth taking as insurance really. K needed for responsible Aspirin use.
• Aspirin (As needed/when I feel i want it): I usually take this when i feel stressed, when I have a lot of work to do, or when I feel like I cant fall asleep. I'll pop 2-3 325mg pills.
• Almost daily Magnesium baths: Love these and they warm me to the bone. I think I really needed supplemental Mag, but I tried glycinate and didn't respond well (got an eye twitch). I usually add baking soda and sometimes aspirin to the baths as well.
• Weekly (or so) Liver, Twice weekly can of oysters, Daily 1-2 egg: Supplemental food that absolutely increased my energy levels. I can now feel when I need to eat a can of oysters or some liver.
• Daily carrot (I almost never actually do the salad)/cooked mushroom: Works. I poop 2-3 times per day now. If I eat something that my gut doesn't agree with I can actually feel that now, which I could not before.All that to say that I think I have the fundamentals down.
Peating thus far has been incredible for my general mood and well being, but despite staying in a calorie deficit I'm once again struggling to lose weight. I prefer staying around 1800-2000 calories at the lowest and I don't like going under 1500 calories. It dramatically decreases my work performance and my energy levels and just frankly makes me feel bad. I want to try and figure out a way to ramp up my metabolism, despite my high levels of stored PUFA, get through this fat and make my metabolism a furnace.
This is a challenge for many overweight people trying out peat principles. I think, based off what I've read from peat and my own intuition, that the challenge in getting the metabolism fired through "peat" mechanisms lies in the vast amounts of stored PUFA in obese individuals.
being a fatty = High PUFA, which = low ATP, High ROS, higher lactate, lower T4 Conversion, inhibited PDH, Higher FFA, = over all less glucose metabolism and inefficient oxidative metabolism
inefficient oxidative metabolism = no mitochondria go burr effect from peating
So all that to say, after a lot of research and thinking about these mechanisms, I'm proposing the following "stack".
On top of maintaining what is already working for me (T3, Progest-e, DEK, Magnesium baths, Aspirin, Liver/oysters/eggs/carrot)
Adding in, for a 6 week test cycle:
Mildronate: ~250mg TTFD: ~100mg Pyrucet (Supplemental pyruvate/acetoacetate) ~ 5 drops
These three are to FORCE turnover to oxidative metabolism. Mildronate shuts down fatty-acid transport, Pyrucet feeds the pathways that burn carbs efficiently, and TTFD switches on PDH so the fuel actually gets used. This combo would hardwire my broken sad body into oxidative metabolism.
I will, of course, be eating a high carb low fat moderate protein diet. Something like 2000 cals, at least 120g protein.
I can ramp these doses up/down as needed by feel, but this seems to me about the optimal ranges to me (open to input).
Anavar, 20mg
Controversial for a female maybe, i know. But I've taken anavar in the past (I used to compete in powerlifting meets, lol). Anavar will help preserve, and build back up muscle through weight loss. It is high-metabolic, helps with cutting, synergizes well with t3 (per the bro scientists) and honestly feels pretty good to be on. When i took it previously, it felt like a secret sauce (I hit a 315 squat at 170lbs in competition which is nothing in the grand scheme of things but was awesome). I think this hormonal shift could really break through my sluggish metabolism, motivate me to lift, and I could be rewarded with gaining some strength back.
Women lack androgenic potential and thus have a way harder time burning fat and also building muscle. This limits our abilities to ramp up metabolism in general, but especially working from the context of already being fat and trying to ramp up metabolism and gain muscle while also losing weight. I think anavar helps me cheat that system a bit.
I plan on going hard in the paint with my x3 bar, 6x week workouts. I'll also do some low intestisy cardio, i.e, walking like 8000-10000 steps per day.
I think continued progesterone usage could mitigate androgenic sides as well. I experienced little in the way of sides in the past regardless. 20mg was the previous dose i felt best at, and honestly as I'm so big, the typical lady dose of 5mg probably wouldn't really do much for me.
If anyone is at all concerned, no I am not at risk of getting pregnant (I am a lesbian).
and to support the liver on an oral,
TUDCA, 500mg
I'd do a six week test cycle, and if i liked it, probably do another 6 week cycle after a few periods. (maybe 8 weeks off?).
This does feel kind of nuclear but also seems kind of fun and like a good experiment. Not a lot of females in this space play with anabolic substances. I'm curious to see if my theories around this are correct, and I want to document the process of this. That is unless you all think i'm going to die.
TL;DR
I'm fat (250lb 30yr female) and want to do drugs (Anavar, Mildronite, TTFD, Pyrucet) on top of the drugs I already do (T3, Progesterone) to fix it. Am I retarded?
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