glycine maxing
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@BioEclectic LLM told me free glycine amino acid is different effect than collagen peptides because in those forms even when the proteins break down they dont all break down into single aminos and many get assimilated as peptide chains with very little free glycine. apparently free glycine has different and more drug like effects and especially for the liver it is different than getting glycine from collagen and foods. i.e. maybe when you take collagen / gelatin you're only getting 200mg free glycine even though "total" glycine content is 2.5g. when you take 2.5g free glycine that is very different effect than the same amount in peptides. also ignore totally Redditors that say it doesn't matter because collagen peptides get broken down into single aminos, that is totally BS and disproven by radiolabel studies showing peptides get uptake directly to tissues.
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@lobotomize said in glycine maxing:
glycine when taken in excess raises serotonin.
Collagen from bone broth induce a histamine reaction.
Bone broth is considered high (H3), while beef collagen is weaker, depending on the way to make it. Let's say H2 to be sure.
And of course, if you take 20 g collagen powder in one take, it's going to make you go to toilet, when not accustomed.
Haidut said once, that 10 g glycine was advised, and that 2 g was assimilated from 10 g (study). Begin with half the dose.Additional info:
Studies indicate that an oral intake of glycine, including a dose of around 5 grams, is likely to increase serotonin levels, specifically in the prefrontal cortex. This increase is thought to be associated with improved mood and sleep quality.
Glycine, an amino acid and neurotransmitter, influences serotonin production and release in the brain. Research, primarily in rats, has shown that oral administration of glycine significantly increases extracellular serotonin levels for a period shortly after consumption.Mechanism: Researchers suspect this effect may be mediated by N-methyl-D-aspartate (NMDA) receptors, which are involved in mood, learning, and memory.
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@sunsunsun said in glycine maxing:
gelatin
Whenever I take gelatine or just pushing a bit extra collagenous foods my joints start making noise .
On the contrary I can eat lean meat and feel good.Two different concepts: the increase of urinary oxalate after consuming gelatin due to its hydroxyproline content, and the use of gelatin as a medium for growing calcium oxalate crystals in laboratory experiments... not good
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@sunsunsun said in glycine maxing:
@BioEclectic LLM told me free glycine amino acid is different effect than collagen peptides because in those forms even when the proteins break down they dont all break down into single aminos and many get assimilated as peptide chains with very little free glycine. apparently free glycine has different and more drug like effects and especially for the liver it is different than getting glycine from collagen and foods. i.e. maybe when you take collagen / gelatin you're only getting 200mg free glycine even though "total" glycine content is 2.5g. when you take 2.5g free glycine that is very different effect than the same amount in peptides. also ignore totally Redditors that say it doesn't matter because collagen peptides get broken down into single aminos, that is totally BS and disproven by radiolabel studies showing peptides get uptake directly to tissues.
Interesting, and jibes a bit with what i've read about other peptide chains that don't necessarily break down to their individual components after ingestion, hydroxyproline being one example.
In my case that i outlined above, adding a full rounded tablespoon of pure glycine and proline to a freshly opened 7oz container of collagen. Would they not remain separate or do you feel they would form new peptide chains and reduce their individual effectiveness? If forced to guess i'd think they'd mostly remain separate but ....
Some new to me info in this thread, i'll have to keep it in mind and research further.
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@BioEclectic no the separate powders won't react as dry powders . what you're saying would only occur under heat where it melts the powders or you add water to make a solution.
I would just keep them separate and not mix them because you might want to take different amounts of glycine and what you mix at first might be too much, and also I dont think you'll mix them evenly in the container, proper pharmaceutical mixing requires rotating drums that go for a certain amount of time or a mortar and pestle to grind the powders to equal densities, and various other methods. just putting it and shaking it around isnt accurate because different powders have different densities and will settle out differently.
also if you mix them and want to take free glycine before bed, you won't have a proper experiment to see if it works well, because ive heard collagen peptides can actually interfere with sleep sometimes, and maybe ive felt this effect myself (not sure but just saying), while free glycine for me promotes restful sleep. etc.
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@sunsunsun serotonin also causes extremely vivid dreams
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@lobotomize said in glycine maxing:
@sunsunsun serotonin also causes extremely vivid dreams
Serotonin maxing
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@LucH said in glycine maxing:
This increase is thought to be associated with
Pay attention to the wording: it is thought, not proven.
@LucH said in glycine maxing:
Research, primarily in rats, has shown that oral administration of glycine significantly increases extracellular serotonin levels for a period shortly after consumption.
Mechanism: Researchers suspect this effect may be mediated by N-methyl-D-aspartate (NMDA) receptors, which are involved in mood, learning, and memory.
NMDA is awful when increased. Most effects we think serotonin does are actually NMDA working in tandem. Trust me, NMDA makes you fucking stupid instantly.
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@user2
If you research the reason why it causes extremely vivid dreams and you seek to maximize this effect, it is because it shortens deep sleep and stretches out REM sleep, causing you to have lower quality sleep. Choline has a similar MOA, so you can min sleep quality with it as well -
@lobotomize yeah sure but i feel great after taking it and sleeping with vivid dreams
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@lobotomize said in glycine maxing:
@sunsunsun glycine when taken in excess raises serotonin.
and if i remember correctly reduces gababeen taking glycine (1g), beef collagen (2 scoops), gelatin (2 scoops) for more than a year, curious where can I learn more about this? what is considered excess..my understanding is having higher serotonin level is not a good thing.. and would like to avoid it if possible.
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@lobotomize drinking 8L of milk a day increases serotonin, yet here we are.
