Help with Pregnenolone Use in Hyperthyroidism
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I was diagnosed with Graves Disease in March of this year, after taking Cynoplus for four months. My TSH has been essentially undetectable since, and I have elevated fT3 and fT4. Symptoms as expected: elevated pulse, high blood pressure, fatigue, sleeplessness, etc. After being unsuccessful using benign interventions like diet, supplementation (magnesium, inositol, as well as various things for my gut), and red light, I decided to give pregnenolone a try since it comes recommended and there seemed to be a lot of trust in the BalancedBodyMind high purity stuff. I started supplementation two weeks ago, and initially the feeling was good. A sense of calm started almost immediately, followed by a desire to do things. Social interaction became very smooth, and because of these factors, I was pretty happy during this timeframe. I also became capable of calming myself and slowing down my heart rate, which I hadn't been able to do in the last few months. Since then I have noticed downsides. Diarrhea, hair loss, insomnia, and sometimes a feeling of restlessness when having to sit still. This points towards a common bad reaction, possibly due to impurity. What do I do now? Is it possible that I just had the wrong dosage? I had to eyeball the amount because I was traveling, but I should have been taking 50 mg at most. The resources on hyperthyroidism in this community are incredibly limited, and I'm not sure how to continue now. Any help is appreciated.
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Assuming your diet is min/max'd (high potassium intake, vitamin D, high milk and OJ, carrot salad, gelatin):
The pregnenolone reaction sounds estrogenic, so the manufacturing is likely trash. I haven't had any issues with healthnatura or idealabs. I've taken 500mg of idealabs pregnenolone and just looked like a cutecel for 2 days.
Not much experience with "hyperthyroidism", but if you have elevated ft3 and ft4 my guess is that the liver isn't doing its job and that t3 isn't reaching the tissues. Besides pufa, if you have an ongoing adrenalinergic state and high blood pressure then the vasoconstriction is probably the cause of the latter. Pregnenolone ought to do the job, but if your adrenals are out of wack then you could try progest-e.
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If this was me
Me
Not youI would stop all supplements
AllAnd get my stress level under control
Meaning
This sounds like a cortisol problemMore to say
But I will stop
and say
Simplify
Don’t confuse -
@adrn100k do you believe your condition was induced by your 4-month stretch of cynoplus supplementation?
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@Sitaruim Yes, from my understanding, thyroid supplementation on low cholesterol can induce a high adrenaline response. My theory is that that led to an autoimmune response, but I can't be completely sure. I wanted to get my cholesterol tested, but for some reason my doctor didn't include it in the blood panel I requested. Have to get that done, will also test for catecholamines. I was diagnosed with Grave's disease based on bloodwork, which is unreliable in diagnosing the actual state of the body, and Ray Peat describes hypothyroid Graves as a state of high adrenaline. I've had trouble finding good information on the topic, but currently it is my best guess, in part due to the strong correlation of me supplementing thyroid and then turning hyperthyroid in the same timeframe.
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@izkrov This is without a doubt a problem of excess stress hormones, the problem is that I have no idea how to control it yet. I was unsuccessful with the more non-intrusive methods, and Peat himself recommended pregnenolone for my condition (Grave's disease, without hallmarks of hyperthyroidism like weight loss, i.e. hypothyroid Graves). The pregnenolone would have served to combat the stress issue, unfortunately the supply still seems to be tainted.
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@izkrov I agree on the liver, will try carb-loading to see if that helps in any way. I also believe that a good quality pregnenolone could solve my problem, but I have the problem that I am German, and I already had to go through great troubles to get the balancedbodymind stuff. I can't get my hands on everything I want. Thought about getting Progest-E, but I'm still on the fence since I heard that men react badly if dosing is wrong, and I don't have access to a physician who can help with that.
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@adrn100k It isn't just glycogen that could be the issue. Vitamins B1 and B2 are necessary for the inactivation of estrogen for example (among other actions on metabolism). High dose thiamine and OJ would be decent to try. Could be other vitamins.
Progest-e is very stable, so at the very least you can trust the manufacturing. It's probably one of the few reasons guys choose it over pregnenolone. Most of the time, the issue is when women take too little, and the inactivated estrogen from progesterone reactivates when it bypasses some kind of inflamed tissue. They simply take a little extra or a few aspirins, or at most switch to vitex and then they're good. I haven't heard of a guy having a bad reaction to it, even past mega doses (though I don't recommend that).
If you take 5 corn kernel drops to start with to suppress whatever adrenalinergic reaction you have (with some extra salt and zinc intake), and then only intake 1-2 droplets a day (standard for men), there's really no chance of any negatives. You'll gain an appetite and intuition for how much of it you need as well, there's really no such prescriptive dosage. I'd even be willing to defend some retards that take too much of it "because it felt right" to them. Less is better though -
I would experiment with all types of stuff
mildronate is one hell of a thing
its winter so I prefer meat and potatoes
summer more fruit
