Does Asprin Affect Fact Loss?
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I'll try to keep my query as simple as possible. Please correct wherever my understanding is off.
I was thinking about a hypothetical protocol for people that were told they have insulin resistance. Since aspirin has been touted as helpful in this regard, its use would be considered in the protocol.
I've read that aspirin has been recommended for such individuals because it promotes glucose oxidation over fat oxidation, which makes sense to me. However, these individuals generally have a good store of body fat which is leaking FFA into the bloodstream and causing metabolic issues, such as the aforementioned insulin resistance.
Would the aspirin, then, affect their fat burning in a way that fat-loss (and PUFA depletion) is slowed or inhibited? I imagine the net effect is still positive, but I'm curious if their weight loss/PUFA depletion takes much longer, thus their total healing takes longer as well.
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You are familiar with the Randall Cycle?
Anyway
These links / articles will answer your questionshttps://www.functionalps.com/blog/2012/04/22/ray-peat-phd-on-aspirin/
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@sphagnum I think people overcomplicate this way too much. If you're fat, there is literally nothing that will even get close to the benefits you will get from becoming lean. Aspirin can help you get there by reducing inflammation along the way, but what really matters is that you get lean if you're fat.
Caffeine + aspirin can work synergistically to oppose inflammation and help the liver clear the fat influx caused by being in a deficit.
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@Peatful I am familiar with the Randall Cycle and was going to mention it in the OP but didn't want to pigeon hole replies in case there were answers outside of that.
I know the Randall Cycle never fully shuts down the fat or carb burning in either direction, but I also don't know how far aspirin swings things in favor of carb burning.
Does aspirin simply 'normalize' a metabolically compromised person's RC back to carb burning, or does it push it to a point where fat burning is minimized and fat retention is still an issue?
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@jamezb46
I agree that lean is the way to go, but achieving fat loss requires that fat be metabolized for energy when in said deficit. I don't know if aspirin may cause a great slowing of this by keeping the switch turned to carb burning.I'm also not sure how much of a deficit is safe without causing issues with thyroid and stress hormones, but that's a whole story I suppose.
