Thoughts on magnesium malate
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I have seen malate can increase oxidation of nadh to nad. Any other benefits or downsides of magnesium malate. Anyone know what haidut thinks?
This is just ai not sure how completely accurate it is but i got this info
Inhibiting the Pentose Phosphate Pathway (PPP): Malate has been identified as a natural inhibitor of 6-phosphogluconate dehydrogenase (6PGD), a key enzyme in the PPP. By inhibiting 6PGD, malate reduces the generation of NADPH and nucleic acids, which are necessary for rapid cell proliferation (a key feature of the Warburg effect).
Promoting Cycle Arrest: Research indicates that malate can induce cell cycle arrest (specifically in the G1 phase) in cancer cells (e.g., CRC cells), thereby reducing their proliferation.
Reducing Lactate Production: By promoting mitochondrial metabolism (oxidative phosphorylation), malate decreases the reliance on lactic fermentation.Increasing PDH Activity
PDH converts pyruvate into acetyl-CoA, allowing for oxidation in the mitochondria, but it is often inhibited by pyruvate dehydrogenase kinase (PDK) in the Warburg effect. Malate helps reverse this:
Reducing Metabolic Shunt Overload: The Warburg effect is associated with overloaded malate-aspartate shuttles (MAS). By aiding in the oxidation of NADH to NAD+ via the malate dehydrogenase (MDH) component of this shuttle, malate helps maintain mitochondrial redox balance, reducing the need for lactic acid production.
Improving Oxidative Capacity: Malate, as a substrate of the TCA cycle, can enhance mitochondrial respiration.
Shifting Metabolism: While not a direct activator of PDH in the same way as DCA (dichloroacetate), malate-mediated inhibition of the Warburg effect (specifically via 6PGD) shifts the metabolism towards oxidation, alleviating the suppression of PDH.Shifting Metabolism: While not a direct activator of PDH in the same way as DCA (dichloroacetate), malate-mediated inhibition of the Warburg effect (specifically via 6PGD) shifts the metabolism towards oxidation, alleviating the suppression of PDH.