Drug that blocks estrogen repairs Inguinal Hernia without surgery

[zorba990]

https://news.feinberg.northwestern.edu/2025/02/05/drug-reverses-groin-hernias-in-male-mice-without-surgery-shows-promise-in-humans/#:~:text=Using a novel%2C medication-based,to repair the hernias medically.”

In the mouse experiment, the scientists injected the anti-estrogen drug fulvestrant, which is currently approved to treat some types of breast cancer, into a humanized mouse model designed to mimic the higher estrogen levels found in aging men. When scientists blocked ESR1 in these connective tissue cells, it prevented muscle damage and hernia formation. Using fulvestrant in the study inhibited the ESR1 in the mice, which helped shrink large hernias and restore the mice back to their healthy anatomy.
In the human arm of the study, the scientists biopsied each participant twice — one from the hernia site and another from an adjacent healthy muscle — and found the same biological markers as in the mouse model. Further analysis showed that estrogen and ESR1 activate a set of genes linked to excessive tissue scarring, matching patterns seen in hernia tissue from human patients.

So wondering, of course, if there is a more natural way to do this. My Estrogen always shows up extremely low on blood work. No pain but would like to get rid of that thing as it sometimes seems to affect pelvic stability in weightlifting.

[sunsunsun]

@zorba990 kind of an amazing find

as for the issue you are talking about maybe you could heal it with a moggy silicon intake. peaty diet is probably deficient in it.