Prolactin is an innocent bystander and may even be beneficial

Ecstatic_Hamster

thank you all for this incredibly valuable thread. @alfredoolivas thanks for starting it.

I suppose like estrogen, prolactin has its good sides. This has helped me see some more research material I would have missed that I can study.

alfredoolivas

After quitting cabergoline, my tiredness has stoppped

engineer

@alfredoolivas at this point I would be worried about not getting in enough food or at least not carb cycling (to lose fat by maximizing carbs only when absolutely needed), because you can feel "not tired" through cortisol which could have been suppressed with cabergoline

alfredoolivas

@engineer cabergoline increases noradrenaline though.

alfredoolivas

“PRL stimulates steroidogenesis in the testes by inducing or maintaining LH receptors in Leydig cells and/or by affecting androgen biosynthesis in Leydig cells via steroidogenic enzymes activity”

https://pmc.ncbi.nlm.nih.gov/articles/PMC10637432/

Kvirion

"The dose makes the poison."

"Alle Dinge sind Gift, und nichts ist ohne Gift; allein die Dosis macht, daß ein Ding kein Gift ist." ~Paracelsus

alfredoolivas

No evidence for prolactin’s involvement in the post-ejaculatory refractory period

Prolactin is released during sexual behavior in male mice.
"Baseline levels of circulating PRL in male mice were low for both strains (**BL6 0.86 ± 0.46; PWK: 2.31 ± 1.37 ng/ml; please see ref. 46 for BL6), but are significantly increased during sexual interaction (Bl6: F3,7 = 21.26, P < 0.0001; PWK: F3,8 = 17.18, P < 0.0001; RM one-way ANOVA) (Fig. 1a)."

Acute prolactin release does not induce a refractory period-like state.

"However, the involvement of PRL in the establishment and duration of the PERP is controversial and has not been formally tested"

"The fact that PRL levels are already elevated during sexual interaction in BL6 and PWK males further suggests that PRL cannot promote by itself reduced sexual activity, at least in male mice"

Mice have different prolactin responses to ejaculation then humans, but it was interesting experiment that does demonstrate how little is known about independent prolactin.

lobotomize

https://lowtoxinforum.com/threads/dhea-has-very-similar-anabolic-activity-to-dht.6019/post-75205

haidut said :

alfredoolivas

@lobotomize in humans prolactin lowers estradiol, so how is it a surrogate for estrogen?

How do you know that lowering prolactin is responsible for improving metabolic parameters? Why isn’t it dopamine or serotonin agonism/antagonism?

Prolactin is clearly an innocent standbyer, that gets the blame for symptoms caused by diabetes, hyperestrogenemia but when you administer prolactin directly, it actually counteracts these conditions.

lobotomize

lobotomize said:

haidut said :

@alfredoolivas

didnt read the attached studies but thought it might intrest you

the whole thread i linked (
https://lowtoxinforum.com/threads/dhea-has-very-similar-anabolic-activity-to-dht.6019/post-75205 ) is riddled with them torting their testicles on the topic of prolactin