Pharmacological ACTH/CRH inhibitor that doesn’t prevent me from doing acid
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Currently taking Mirtazapine to help with seemingly unstoppable ACTH/cushing’s symptoms, likely as a result of either past SSRI (ab)use or ashwaganda (🤮) use pre-peating.
I also just like the calming/stress-resistance effect it gives me. Feels like my fight or flight response takes a lot more to activate than it used to and it helps me to run on thyroid and not be adrenal-dominant.
However, I do really enjoy taking acid on occasion and not only does Mirtazapine acutely block psychedelic trips (5ht2a, 2b, 2c antagonist) it also has a disgustingly long half life and withdrawal symptoms which makes weaning off/on for acid trips too annoying.
It may also elevate TNF-alpha which makes me want to get off it as well but if we’re being honest here the main issue is I really just want to take acid.
I have seen acetazolamide mentioned on RPF as something that lowers ACTH, and I know it isn’t a serotonin antagonist. Would this be sufficient? Cyproheptadine kind of works but I can’t stand the anticholinergic effects for more than a day in a row.
Any other serotonin 5ht2c antagonist that’s known to lower ACTH and doesn’t have a disgustingly long half life would also be acceptable. Any suggestions whatsoever appreciated.