Since spring, I’ve been on TRT, clomiphene, pregnenolone, and DHEA. My testosterone is over 1000, estrogen is 61 (high per the test), DHEA is high (451), and pregnenolone rose from 15 to 30 but is still low.

I called my TRT doctor last week because I don’t feel as good as I did a few months ago. The constant “zest for life” and feeling unstoppable have become occasional, and I’ve felt more emotional. I assumed it was from high estrogen, but my doctor dismissed this, saying the testosterone-to-estrogen ratio is fine and I lack typical symptoms like nipple sensitivity.

The other morning, I had one of those waking pre-conscious thoughts to try Progesterone. I had a bottle of Progest-E, so I swapped my usual pregnenolone for a small amount (1-2mg) on my wrist that night. Within 20 minutes, my face warmed, my mood lifted, and I felt calm—completely different from pregnenolone, which usually does nothing for me. The next night, I tried 3-5mg with the same result.

Yesterday, I felt good overall but noticed some aggression after the gym. Not sure if it’s the Progest-E or unrelated.

I have a few questions:

1. How often can I take this progesterone? One of the things I'm worried about is that my testosterone is already high, and if less estrogen is aromatizing then it could drive my testosterone even higher

2. How would you consider taking DHEA and pregnenolone with it? Can I take them all together or should I do like one week pregnenolone, one week progesterone? My pregnenolone levels are still low (which I think is from it converting to cortisol)

3. What kind of side effects should I be on the look out for? Like what would be an indicator that I've overdone it and should back off taking more progest-e?

Edit: Also want to add within maybe 30 mins - an hour of taking the Progest-E my libido went through the roof, but felt different than the TRT horniness that I get sometimes which feels more like high estrogen and compulsive more than anything. Not sure what to make of that

@Insomniac ha well my doctor lowered my dosage, I think superhuman wasn't the right word to use with them lol. I definitely don't feel superhuman now.

What do you mean the psychological impact of TRT? Can you speak more about that?

Here's my results so not sure if 61.2 is dangerously high or what

Hi,

I went on TRT/clomiphene 4 months ago to help recover from a brain injury, and within a month I felt like my old self after almost 3 years of post concussion syndrome. In addition, my neuroendocrinologist also put me on Pregnenolone 50mg and DHEA 10mg, both Life Extensions brands.

Last month, we re-ran my labs and my testosterone was almost 1100, which was no surprise because I felt super human. My estrogen was also high, Pregnenolone was low, DHEA was high.

My Dr. recommended I take a supplement called DIM detox (https://smartq.pureforyou.com/products/32040737734690/dim-detox) to help stop the aromatization of test ---> estrogen, but every time I take it I feel apathetic and a low level depression, so I stopped taking it and have been taking higher dose vitamin E.

My thought process is that the Pregnenolone is further helping strengthen the pathway of Preg ---> DHEA ----> Test ----> Estrogen and Progesterone will help oppose Estrogen, although also think there could be a Cortisol steal thing happening with the low Pregnenlone, since my body was stuck in fight or flight for about 3 years.

Any ideas how to approach this? I have a bottle of Progest-E sitting in my fridge but want to be mindful with the hormone protocol I'm on not to fuck anything up.

@hcwilliams how's your lutenizing hormone?