Propranolol, agression & autism

[Uroš]

Since there is a known issue with autistic children and problems of increased aggression and fight-or-flight susceptibility during puberty, my question is: does anyone have personal experience with propranolol?

It's a well-known, old beta-blocker. According to literature , it is one of the few medicines which directly attenuates aggressive outbursts and lowers the fight-or-flight response. Also used "off-label" for above stated issues.

A concern is bradycardia and hypotension in children. Since only available dosage is 40 mg. Tablet can not be divided.

I know cyproheptadine is useful for lowering serotonin, but it is not available in our region, nor in neighboring countries.
Personal experiences are more welcome than PubMed linking.

Kind regards

[Chud]

alldaychemist does not ship cyproheptadine to your country? they have Best cypro for extremely cheap.
https://www.alldaychemist.com/ciplactin-4mg.html

[bot-mod]

No experience but it ought to be of interest to everyone.

@Uroš said in Propranolol, agression & autism:

A concern is bradycardia and hypotension in children.

Interesting. Maybe Wakefield was right about the vagus nerve, or a stop on it.

"Propranolol acts by blocking vasodilatory beta 1 receptors and reducing cardiac output. A major side effect of vasopressin therapy is impaired cardiac performance secondary to coronary vasoconstriction and increased work against high arterial pressure."

@Uroš said in Propranolol, agression & autism:

Personal experiences are more welcome than PubMed linking.

Blogs ok ✓

https://www.epiphanyasd.com/2020/02/thirst-too-much-or-too-little.html?m=1

[Uroš]

@ThinPicking thanks.