Estrogen use increases the risk of ovarian and endometrial cancer.
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Estrogen is the body's primary signal to stimulate cell division and de-differentiation. It mimics the injury state by suppressing mitochondrial metabolism.
Both suppressed metabolism and de-differentiated cells are the main features of cancer. Meanwhile, Progesterone is such a strong anti-cancer agent that even when given with estradiol, it slashes cancer risk.
Progesterone opposes estrogen everywhere, and since estrogen is an endogenous cell injurant, progesterone is a universal cell protector.
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