No dose of aspirin increased my body temperature. That it raises metabolism is mythology imo
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This is a great question and I am watching the answers.
My first thought was aspirin resistance (AR). Yes, it is a real thing. Avoiding AR is one of the reasons that MDs do not routinely recommend taking low dose aspirin on a continuing basis.
“All things are poison and nothing is without poison; only the dose makes a thing not a poison.” - Paracelsus (c. 1493–1541)
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@Insomniac said in DNP causes fat loss by uncoupling. Aspirin uncouples but doesn't cause fat loss. Is there a dose where there is eventually a DNP like effect? If not why not?:
Did you notice it help you lose fat with the tweaks?
What I see is that when I take B3 high dose (niacinamide 100 mg), I don't lose fat. I gain some. According to theory, lipolysis shouldn't have last more than 2 hours long. But not with me when taking B1 B2 B3 B6 and TMG at breakfast + B1 at midday (500 K/cal, with optimal ratio for macronutrients (G40 - L20/30 - P20/30, among which SFA).
These "tweaks" are to recent to sea an evolution on my "living state" (71 years old, 84 kg). Not bad but could be better. Tend to be lazy.
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When I want to lose wait I create a deficit 20 % 5 days a week. and 2 days a week I follow 5.2 diet. 2 days (not 2 contiguous days) with a serious deficit, 2 meals
Breakfast round 10 a.m. with 2 eggs, one apple or an orange. Need a few carbs (> 20 g) to avoid an insulin peak, with only proteins.
At +/ 4 or 5 o'clock: a protein (steak 120 gr), a fruit and a bowl of soup. -
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@Insomniac said in DNP causes fat loss by uncoupling. Aspirin uncouples but doesn't cause fat loss. Is there a dose where there is eventually a DNP like effect? If not why not?:
Maybe this is around where it starts to increase metabolism. Hard to say
Have you taken into account a long-time use of aspirin on platelet (less).
Must be compensated with staples when taking aspirin, and pauses.
I won't target my objectives with only aspirin. Need more CO2 ...Serotonin's Journey: Intestine to Brain Effects
"Events in the intestine, where most serotonin is produced, in the blood where it’s transported, and in the lung, where much of it is detoxified, will affect the brain. Toxins produced by intestinal bacteria cause serotonin to be released into the bloodstream, and if the platelets aren’t able to keep it tightly bound until the lungs can eliminate it, some of it will reach the brain, where it will interfere with sleep and other brain functions."- July 2019 - Ray Peat's Newsletter
Lungs' Role in Detoxifying Serotonin with CO2
"Although the liver has a much larger capacity than the lungs for detoxifying serotonin, the lungs detoxify several times as much of the circulating serotonin as the liver does. The reason for this is that in the high oxygen environment of the lungs, carbon dioxide is lost from the blood, and carbon dioxide is needed for retention of serotonin by the platelets. With the loss of CO2, the platelets release their serotonin very quickly, to be immediately detoxified by the local MAO." -
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thanks for this thread.
i'm trying to find dnp in europe.
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@Insomniac This is not scientific or precise, I'm not sure what's going on, but I get a noticeable increase in body temp, ramping up metabolism when I take 1000-3000mg aspirin with 1000-2000mg caffeine throughout the day. No noticeable fat loss tho like with DNP.
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