why would I no longer tolerate Pregnenolone?
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I'm a male, both Pregnenolone and Progesterone are low.
In the past, I remember some benefits when using Pregnenolone, but now I just get more anxiety and more stress, overly exited as well. I suspect it converts too much into Pregnenolone-S
Does anyone know what could cause the over conversion of Preg to Preg-S?
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What pregnenolone product are you taking?
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Compounded SR oral
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I tried searching but found many diffrent options. Do you have the brand name or link to the pregnenolone product you're using?
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Mine comes from a compounding pharmacy, you going to need a script from a doc for it.
A good brand that it is known in the Peat community is Health Natura powder Pregnenolone, otherwise look for a micronized Pregnenolone supplement that had almost zero fillers.
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@GRay Have you tried taking a break and does the intolerance persist? Say, 3-4 weeks?
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I can't really tolerate it for 3/4 weeks, last time I tried I had to stop at a week marker from starting, insomnia was another issue I had.
I tried also cream, and by the 3rd or 4th days I would get even stronger anxiety and increased HR than capsules.
I was taking Pregnenolone consistently starting the 2019, I remember feeling a bit wired or something by the 3rd day, but I would notice the benefits and the increased blood level of Progesterone, which is my main goal here
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@GRay This isn't a suggestion, but have you tried diff modes of delivery: topical, oral, sublingual, even scrotal?
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@GRay, I’m not sure about over conversion, but do you know at what temperature the current pregnenolone you’re using is processed at? Ray said that pregnenolone becomes estrogenic when processed beyond a certain temperature and that he stopped recommending it because he was unaware of a source that was processed at a low temp. I’ve tried finding one that is low-temp processed, but so far have had no luck. I want to see if it works as well as progesterone for pain relief, but without the gnarly symptoms I get supplementing progesterone.
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@albion I tried everything through the years, beside injectable.
For some reason, I do not have the issue with the scrotal application, but it doesn't convert to Progesterone, and it actually feels more like something else when applied on the scrotum, more like androgen like I would say.
There is a thread on the older forum from Haidut on progesterone on scrotum raising androgens.
This is funny though, as exactly two years ago I was just doing ok with a 50mg oral Preg SR from compounded pharmacy, and my levels always came back low without supplementation.
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HI @Jennifer
I did not know this. The symptoms I was experiencing could actually resemble those of excess estrogen, since there was some hyperexcitability as well. However, Pregnenolone sulphate is totally capable of doing the same, as it also cause cell excitation by allowing Ca to enter the cells, just like estrogen.
I can confidently say that Preg-S can just do the opposite of Progesterone.