The immortal, eternal Bryan Johnson broke his frail, childlike ankle while dancing at age 47
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Higher metabolic rate means more co2 production. More co2 production means less bone catabolism. Those with marble bone disease have a carbonic anhydrase deficiency and that is considered to be the cause of the massively hypertrophied bones.
So, in reality if Bryan Johnson wants to heal, he should first of all get off his stupid hypocaloric diet, incease his metabolic rate, and possible take some thiamine or acetazolamide, both of which inhibit carbonic anhydrase.
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I suppose he could be honest about what he takes, but perhaps there are things he doesn't document, such as injectable androgens or other "frowned upon" therapies.
I would be more surprised if he was 100% transparent than if he had some skeletons in the closet.
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@jamezb46 nice. thanks for sharing. do you have any convenient research/articles/videos or Ray quotes on supplementing acetazolamide?
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With a temp of 93.4°, he is extremely hypothyroid so it makes sense he would break bones easily—the thyroid/parathyroid glands are the main glands involved in bone/connective tissue metabolism. Also, if his diet and/or supplement stack is irritating and/or estrogenic, that can contribute to bone thinning as the former raises serotonin and both serotonin and estrogen cause bone thinning (per Ray). A low irritation diet abundant in nutrient-rich animal proteins (raw milk, raw yogurt, raw cheese, eggs, bone broth and small amounts of meat—mostly shellfish) reversed my advanced osteoporosis. I went from a DEXA score of -6.7 to -3.6 within a year. Just for reference, -3.4 is considered osteopenia and -3.5 is osteoporosis. With the addition of a thyroid supplement (standardized NDT), I’ve slowly been gaining back the 4” of height I lost when my spine collapsed in my late 20s, while following a high-carb, low-protein, fruit-based (80/10/10) diet. My bones were so brittle that I fractured 12 vertebrae, 8 of which compressed, within seconds of lifting half a watermelon.
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@Jennifer good grief. Well done!
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@LetTheRedeemed None that I'm aware of that discuss dosing or protocols, but I do know that he recommended it for sleep apnea on the generative energy streams.
^^ Here is a generative energy podcast with Georgi discussing osteoporosis and how certain hormones and/or substances promote bone reabsorbtion (prolactin, cortisol, estrogen, to name a few)
At 12:00 they start discussing carbonic anhydrase and marble bone disease.
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@jamezb46 oh cool. Thanks!
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Thank you, @Lizb.
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Interesting Johnson clip from twohands on rpf about his use of thyroid here.
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"What do you suggest?" seems defensive... but I think he's actually asking.
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lol pushkin
