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    High dose biotin and liver cancer.

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    • L
      Living_thing @the_black_jew
      last edited by

      @the_black_jew Thanks, I hadn't heard of apatone before.
      A combination vitaminK and vitaminC.
      The main reasoning behind combining B vitamins and aspirin is that they help bypass metabolic blockages.

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        Living_thing @Ecstatic_Hamster
        last edited by

        @Ecstatic_Hamster Thankyou. I've heard a lot about RSO and yet i've looked a little and been unable to find a mechanism behind it.
        Do you have an idea why THC is effective?

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          the_black_jew @Living_thing
          last edited by the_black_jew

          @Living_thing just replace the k3 with methylene blue in same dose . it’s 100:1 iirc i.e. 50mg methylene blue and 5g vitamin c per day. split up .

          the safe reasonable dose of MB is 15mg per day. could do 5mg MB 3x per day and 1g vitamin C 2-3x a day. the ratio isnt the same as the official k3/vit c dose, it’s probably effective anyways when stacked with cypro and aspirin.

          the cypro dose is 4mg 3x per day for normal
          size woman in the case study where cancer is cured . might want to monitor liver enzymes on this dose or try like 4-6mg total per day. stacking the other stuff makes the doses needed lower for most things.

          aspirin as needed probably about 1.5g total. georgi has a post with references to the aspirin dose for liver cancer from animal studies.

          take a bit of k2 mk4 for the thin blood

          would also add thiamine and niacinamide and up to you if you wanna try the biotin, in my experience it can cause somewhat painful acne

          and the finally maybe a few drops of 8:1 cortinon+.

          that’s a basic metabolic cancer protocol that will support deranged cells to either go back to normal and also autoschizs of the ones that can be killed off.

          for diet i would include raw carrot and red cabbage and focus on gelatin to make up even up
          to 40-50% of protein intake. and relatively low fat. ive also heard brocolli sprouts are good yet even raw carrot has bioactives that test stronger than that despite people on peaty discussion groups saying cruciferous stuff is not ideal

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            Ecstatic_Hamster @Living_thing
            last edited by Ecstatic_Hamster

            @Living_thing it epigenetically changes cancer cells into normal cells. It literally gets rid of tumors.

            When I hear "where is the mechanism" I have to sort of chuckle.

            There are tons of papers on how THC fights cancer.

            Did you know that every nerve cell in the body uses endocannabinoids to signal "stop--stop firing" to the nerve upstream of it that is firing?

            And that we are floating on 20L of fluid, known now as a "new organ", the interstitium, fed by our lymphatic system?

            https://www.nature.com/articles/1210641
            Δ9-Tetrahydrocannabinol (THC) is the primary cannabinoid of marijuana and has been shown to either potentiate or inhibit tumor growth, depending on the type of cancer and its pathogenesis. Little is known about the activity of cannabinoids like THC on epidermal growth factor receptor-overexpressing lung cancers, which are often highly aggressive and resistant to chemotherapy. In this study, we characterized the effects of THC on the EGF-induced growth and metastasis of human non-small cell lung cancer using the cell lines A549 and SW-1573 as in vitro models. We found that these cells express the cannabinoid receptors CB1 and CB2, known targets for THC action, and that THC inhibited EGF-induced growth, chemotaxis and chemoinvasion. Moreover, signaling studies indicated that THC may act by inhibiting the EGF-induced phosphorylation of ERK1/2, JNK1/2 and AKT. THC also induced the phosphorylation of focal adhesion kinase at tyrosine 397. Additionally, in in vivo studies in severe combined immunodeficient mice, there was significant inhibition of the subcutaneous tumor growth and lung metastasis of A549 cells in THC-treated animals as compared to vehicle-treated controls. Tumor samples from THC-treated animals revealed antiproliferative and antiangiogenic effects of THC. Our study suggests that cannabinoids like THC should be explored as novel therapeutic molecules in controlling the growth and metastasis of certain lung cancers.

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              16charactersitis @Living_thing
              last edited by

              @Living_thing I I would try to up b1 with (lean) pork (eg, ham) and seafood, b3 with lots of OJ, all b vitamins with brewer s yeast (eg sprinkle on soups popcorn etc) and k from liver or kale. One can always add actual supplements. Ironically it seems Aniprin brand veterinary aspirin is the one of the ones with the least or no additives.

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                Living_thing @the_black_jew
                last edited by

                @the_black_jew Thankyou, that all matches with my thoughts.
                Sulphurophane in brocolli sprouts is a good anti fungal iirc.

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                  Living_thing @Ecstatic_Hamster
                  last edited by

                  @Ecstatic_Hamster Interesting stuff. Thankyou.
                  The acidification of interstitial fluid is certainly one of the problems.
                  My wife has been doing some light bouncing on a rebounder and appreciates the effect it has.

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                    Living_thing @16charactersitis
                    last edited by

                    @16charactersitis
                    Human equivalent doses based on bodyweight from Mr DInkovs mouse study - "Daily dose (administered once daily, orally): ~15mg/kg vitamin B1 (thiamine), ~30mg/kg vitamin B3 (niacinamide), ~1.5mg/kg vitamin B7 (biotin), and ~15mg/kg aspirin.

                    Yeast is very high in b vitamins but isnt a practical source for Biotin.

                    • Thiamine (B1): Nutritional yeast requires much less quantity (~30g) compared to brewer's yeast (~187.5g).
                    • Niacin (B3): Nutritional yeast also requires less (~75g) compared to brewer's yeast (~107.1g).
                    • Biotin (B7): Both sources require impractically large amounts, especially nutritional yeast (375g). You would likely need a biotin supplement to meet this requirement.
                      For Biotin (B7) supplements are needed. a 50kg person would need to eat ~750 eggs daily or 21kg of liver.

                    It's a lot of yeast.
                    I tried making crackers and adding it to food etc, but it gets unpleasant.

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                      16charactersitis @Living_thing
                      last edited by

                      @Living_thing ok. What you might try, if you like, is dissolving the yeast in warm water as ray suggested. Then just use the water (where the vitamins are) and throw out the solids. That way it’s easier to digest and makes a nice broth by it self with a sprinkling of chives or onion powder and salt to taste. Or Can be used in soups, stocks, sauces, etc

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                        Living_thing @16charactersitis
                        last edited by

                        @16charactersitis from looking at how its done industrially it seems warm alcohol is the way to go, yet its tricky to not denature the vitamins

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                          16charactersitis @Living_thing
                          last edited by

                          This post is deleted!
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                            16charactersitis @Living_thing
                            last edited by

                            @Living_thing i guess alcohol would work if you’re making a batch. I was thinking of heated water to extract the vitamins at the time one is having one serving. I’ll try and find the article Ray Peat mentions doing this.

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                              16charactersitis @16charactersitis
                              last edited by 16charactersitis

                              @16charactersitis @Living_thing
                              Here it is. It was from an email exchange not an article:
                              “Brewers' yeast..best to start by pouring hot water over an ounce or two of it, and using just the liquid”
                              From here:
                              https://lowtoxinforum.com/threads/ray-peat-email-advice-depository.1035/page-11

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                              • daposeD
                                dapose @Ecstatic_Hamster
                                last edited by

                                @Ecstatic_Hamster
                                Aren’t you a moderator on the Low Toxin Forum? I don’t trust you. When people were getting banned left and right on the Ray Peat forum you were never saying anything. Why?
                                If I am wrong about this I will completely apologize because it’s not like me to post comments like this but every time I see your name on this forum i cringe and I don’t want to feel like that. What am i missing? You also have such strong convictions and ideas that don’t seem to be Bioenergetic or Ray peat adjacent. Obviously that’s fine to have your own ideas and this is all about discourse…
                                Any thoughts? Am I just totally wrong? It was a huge forum and I could absolutely be wrong.

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                                  Ecstatic_Hamster @dapose
                                  last edited by

                                  @dapose I have no idea what you are talking about. I'm not a moderator of any forum. I think you are totally wrong. I'm a close friend with people on these forums, and I am a huge follower of Dr. Peat's ideas. I think you have mistaken me for someone else.

                                  I do have my own ideas about a lot of things. I think Dr. Peat was wrong about eccentric exercise, for instance. And he didn't study cannabis enough to have good opinions. So many things. But he was right on many core issues and he was a thinker and didn't follow the bros. My regret is never meeting him in person, although I do have many email correspondences and am lucky to have had a lot of communication with him via email when he was alive.

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                                  • daposeD
                                    dapose @Ecstatic_Hamster
                                    last edited by

                                    @Ecstatic_Hamster far out!! I’m sorry for insulting you like that but I do feel a lot better bringing it up. The tremendous stress that forum caused just clearly gave me some lasting trauma.
                                    Anyways. Hope you are well and sorry to bother you.
                                    I was alittle triggered by this cancer and b vitamin thread too. Which is a common topic. This poor persons wife is suffering from cancer, and they have clearly looked into it with Georgi’s research. All of Georgi’s work with B vitamins and aspirin etc… The person has a specific question about biotin… and then I see you post about thc enemas. In all my years researching health and anti cancer things I have never heard anything good about thc and enemas. It just doesn’t seem helpful to this persons thread and inquiry.
                                    It seemed deliberately derailing to me. Like the guy is really trying to figure out a protocol he has looked into and trying to get specifics on it, and you throw in an idea out that has nothing to with what he’s asking about. Keeping a very long story short. I have lost two very close relatives to cancer in the last 3 years. One 45 one 32. Everyone was trying to help them with bad idea after bad idea. My sister got so over whelmed with what to do…
                                    All of Rays work and Haiduts are the best helpful things I’ve ever found for my similar situation. I’ve looked into everything health related for 20 years and i am not saying I understand it all! Just looking… learning.

                                    My point here is that bombarding people with ideas isn’t always the right thing to do to help people .
                                    There is a reason Ray was never rambling on in interviews when asked if there was anything else he wanted to say. Because he understood that anything can be dangerous when taken out of context and just haphazardly throwing out more “good” ideas isn’t helping anybody. Literally anything could be a stress/toxin when hypothyroid and in cancer metabolism.
                                    Peace

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                                      Living_thing @16charactersitis
                                      last edited by

                                      @16charactersitis Thankyou

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                                        Ecstatic_Hamster @dapose
                                        last edited by Ecstatic_Hamster

                                        @dapose When someone says they are triggered, to me it's a case of "well, then, why don't you tune out or go away from what is bothering you." Just because "you" never heard of THC helping or enemas helping. So it must be false. You haven't heard of it. But then again, maybe you weren't listening because you got triggered.

                                        Me, I want to be triggered. I want to hear what someone has to say. Even if I don't like it. Especially so.

                                        And you give me a sideways criticism too. I'll mind mind my own business, and post what I want to post.

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                                        • DavidPSD
                                          DavidPS @Living_thing
                                          last edited by DavidPS

                                          @Living_thing said in High dose biotin and liver cancer.:

                                          Ray said that there were old animal studies showing that high dose biotin caused liver cancer. https://www.bioenergetic.life/clips/d743f?t=1572&c=35

                                          Page 50 of Dr. Peat's book entitled Nutrition for Women:
                                          fcea2004-152e-462e-b853-b3782d85b31b-image.png

                                          “Medical science has made such tremendous progress that there is hardly a healthy human left.”
                                          Aldous Huxley 👀
                                          ☂️

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