Effect of Creatine Monohydrate Supplementation on Macro- and Microvascular Endothelial Function in Older Adults
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The protocol in the following study
- 20 grams per day for 5 days (four 5-gram doses daily)
- followed by 5 grams per day for 23 days.
Results: CrM significantly increased FMD% (pre-CrM, 7.68 ± 2.25%; post-CrM, 8.9 ± 1.99%; p < 0.005), and normalized FMD% (pre-CrM, 2.57 × 10-4 ± 1.03 × 10-4%/AUCSR; post-CrM, 3.42 × 10-4 ± 1.69 × 10-4%/AUCSR; p < 0.05), compared to PL. Microvascular reperfusion rates increased following CrM (pre-CrM, 2.29 ± 1.42%/sec; post-CrM, 3.71 ± 1.44%/sec; p < 0.05), with no change following PL. A significant reduction in fasting glucose (pre-CrM, 103.64 ± 6.28; post-CrM, 99 ± 4.9 mg/dL; p < 0.05) and triglycerides (pre-CrM, 99.82 ± 35.35; post-CrM, 83.82 ± 37.65 mg/dL; p < 0.05) was observed following CrM. No significant differences were observed for any other outcome.
Conclusions: These pilot data indicate that four weeks of CrM supplementation resulted in favorable effects on several indices of vascular function in older adults.
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Conclusions
In older adults, acute creatine supplementation can positively affect vascular parameters of arterial stiffness and atherosclerosis. Creatine supplementation has the potential to serve as a potent adjuvant in the management of CVD for older adults.
“All things are poison and nothing is without poison; only the dose makes a thing not a poison.” - Paracelsus (c. 1493–1541) 👀
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@DavidPS Thanks for sharing David.
I've used this together with urea before. Based on Greek doctor Dianapoulos ? whom Peat has written about on the subject of urea.
I think urea improves on the liver , as seen on the reduction of liver enzymes ALT and AST in blood, which indicates the reduction of stress on the liver. But since the liver will also filter out urea by its various detoxifying mechanisms, urea barely goes past the liver to heal or repair internal tissues and organs. And this is the reason creatine monohydrate was added to urea in his therapies.
I had taken his suspension (not a solution as creatine does not fully dissolve) daily for 2 weeks where I mixed 30g of urea and 14g of creatine monohydrate in a liter of water, and I would drink that suspension throughout the day, shaking each time the suspension.
But it was difficult to see improvements internally in the absence of a metric I could use.
But from the study, it looks like there is proof to justify taking creatine, especially in the microvasculature.
Thanks again!
Temporal thinking is the faculty that’s
engaged by an enriched environment, but it’s
wrong to call it “thinking,” because it’s simply
the way organisms exist... - Ray Peat Nov 2017 Newsletter -
@yerrag -
I am primarily interested in the microvascular effects as well. My interest is in brain cognition. I assume the microvascular effects are there as well.
Results: During a median follow-up of 8.6 years, there were 1512 (45.8%) cognitive function declined. After adjustment, the highest quartile of the SUA/SCr ratio was associated with the highest risk of cognitive function decline (Hazard ratio, 1.175; 95% confidence interval, 1.015–1.360). Restricted cubic spline showed a linear association between the SUA/Scr ratio and the risk of cognitive function decline (pnon−linear=0.514). There were a stronger association of cumulative SUA/Scr ratio and its exposure burden with cognitive function decline [the highest versus lowest quartile: 1.635 (1.006–2.656), the high versus low group: 1.729 (1.212–2.466), respectively]. No significant mediating effect through white blood cell count or C-reactive protein in SUA/Scr ratio-cognitive function decline was found.
Conclusions: The SUA/Scr ratio was associated with a higher risk of cognitive decline, whereas the mechanism mediated
by inflammation indicators was not found.
