TLR4 activation
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I recently discovered the root cause of my health problems and it’s related to endotoxin.
Research on my condition has indicated that there’s a chronic activation of TLR4, the toll like receptor that gets turned on by LPS, or endotoxins.
This activation causes my chronic IBS symptoms, makes it so my thyroid therapy can never work fully, and basically serves as a bottleneck to my health that can’t change until I rectify this.
I’m already doing everything I can to minimize endotoxin itself, but I want to focus on the TLR4 receptor too and see if I can antagonize that as well, it seems to be very important.
Does anyone know of any ways to impede or antagonize this receptor?hopefully quelling some symptoms?
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@Ibshaver23 said in TLR4 activation:
Does anyone know of any ways to impede or antagonize this receptor?
You're trying to fight against the consequence, not the cause. If endotoxins are the problem, I'd try to make it easier to get rid of them.
TLR4 activates both the MyD88-dependent and TRIF-dependent pathways. Activation of these pathways is controlled by several molecules to induce appropriate responses. Balanced production of inflammatory cytokines and type I IFN may be important for controlling tumor cell growth and autoimmune diseases.
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2014.00461/full.
I can give a link if interested on how to make it easier to get rid of LPS. -
@Ibshaver23 naltrexone low dose
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naltrexone blocks TLR4
https://longestlevers.com/anabology-top/low-dose-naltrexone.html
Pregnenolone Is A Potent (functional) Endotoxin (TLR4) Antagonist
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@Ibshaver23 hesperidin from orange juice inhibits TLR4, ferulic acid too
