Visceral fat reduction by enteric-coated lactoferrin
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An interesting study from Japan.
Lactoferrin (LF) is a multifunctional glycoprotein found in mammalian breast milk. Its primary function was thought to be antimicrobial or immunomodulatory activity because it is present at high concentrations in breast milk. In recent years, several studies have shown other functions of LF, including modulation of lipid metabolism. The purpose of this review is to summarize the current knowledge of the effects of LF on systemic lipid metabolism. In vitro studies have revealed anti-adipogenic and lipolytic activities of LF against adipocytes. In vivo studies have also demonstrated that LF can decrease plasma, hepatic triglycerides and cholesterol and can reduce visceral fat. In human epidemiological studies, the circulating LF concentration is reportedly inversely associated with BMI, waist:hip ratios, fasting triglyceride and glucose concentrations and positively associated with insulin sensitivity. Moreover, oral supplementation with enteric-coated LF reduced visceral fat accumulation in a randomized controlled trial.
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Lactoferrin (LF), a multifunctional glycoprotein in mammalian milk, is reported to exert a modulatory effect on lipid metabolism. The aim of the present study was to elucidate whether enteric-coated LF (eLF) might improve visceral fat-type obesity, an underlying cause of the metabolic syndrome. Using a double-blind, placebo-controlled design, Japanese men and women (n 26; aged 22–60 years) with abdominal obesity (BMI . 25 kg/m2, and visceral fat area (VFA) . 100 cm2) consumed eLF (300 mg/d as bovine LF) or placebo tablets for 8 weeks. Measurement of the total fat area, VFA and subcutaneous fat area from computed tomography images revealed a significant reduction in VFA (214·6 cm2) in the eLF group, as compared with the placebo controls (21·8 cm2; P¼0·009 by ANCOVA). Decreases in body weight, BMI and hip circumference in the eLF group (21·5 kg, 20·6 kg/m2, 22·6 cm) were also found to be significantly greater than with the placebo (þ1·0 kg, þ0·3 kg/m2, 20·2 cm; P¼0·032, 0·013, 0·041, respectively). There was also a tendency for a reduction in waist circumference in the eLF group (24·4 cm) as compared with the placebo group (20·9 cm; P¼0·073). No adverse effects of the eLF treatment were found with regard to blood lipid or biochemical parameters. From these results, eLF appears to be a promising agent for the control of visceral fat accumulation.
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Just for review:
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What about liposomal lactoferrin? Hard to find any enteric-coated products in the EU.
Also, is apolactoferrin better or worse from a Peaty perspective? They have different effects on iron metabolism.
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@revenant - It hard to find enteric-coated here in the US as well. I found one product on Amazon that is produced in Japan. It is called "Doctors Mega Lactoferrin – 120 Enteric-Coated Tablets".
As shown in the image above, the coating delivers the lactoferrin to the colon.
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See another thread about enteric-coated lactoferrin. I was hoping not to find any negative effects of translocating the lactoferrin delivery to the colon.
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I’ve had positive experiences with lactoferrin supplementation, and decided to give the enteric version a shot.
My personal experimentation with regular lactoferrin has resulted in better sleep, more frequent morning erections, and vivid dreams and recall, (a positive for me since I practice lucid dreaming). It also seems to have a strong anti-inflammatory effect for me. I’m particularly interested in the enteric coating to see what anti-inflammatory effects this might have on the small intestine. My wife has had issues with SIBO in the past and I was hypothesizing that perhaps a reduction in iron, (as lactoferrin is known to bind) especially in the small intestine might be a more holistic/environmental change dissuading bacterial colonization in the area vs antibiotics alone with no change in environment.
I bought enough to trial this for a few months, (the studies were 8weeks).
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@evan-hinkle said in Visceral fat reduction by enteric-coated lactoferrin:
I bought enough to trial this for a few months, (the studies were 8weeks).
Great, let us know if the enteric coating produce any additional effects.
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@evan-hinkle said in Visceral fat reduction by enteric-coated lactoferrin:
My wife has had issues with SIBO in the past and I was hypothesizing that perhaps a reduction in iron, (as lactoferrin is known to bind) especially in the small intestine might be a more holistic/environmental change dissuading bacterial colonization in the area vs antibiotics alone with no change in environment.
I was never diagnosed with SIBO, but have been eating a special high potency yogurt made using L. Reuteri bacteria. It is not a cure but it keeps my sensitivity to nightshades at bay. I have written about it here. Dr. Davis has recently written a book about the benefits of the yogurt entitled "Super Gut: A Four-Week Plan to Reprogram Your Microbiome, Restore Health, and Lose Weight?
In addition, YouTube has many videos about L. Reuteri yogurt.
https://www.youtube.com/results?search_query=l.+reuteri -
@evan-hinkle hey buddy, it’s been a while, hope all is well
What dose were you taking of regular lactoferrin? Were you taking it on an empty stomach? Also which brand were you using? Thanks bud -
@Ismail hey man, doing well! I was taking 500mg Jarrow freeze-dried lactoferrin.
And just a general update: I’ve been taking the enteric coated for a few months now, and I actually think I prefer the ones I was taking before. I replicated the study above taking 300mg of the enteric coated, and really didn’t notice anything at all, (which is odd because I respond to most everything I try, (good or bad)).
TMI: I saw an undigested enteric coated lactoferrin in my stool last week, (great, they’re making it past the stomach-bad, I’m literally shitting my money away…).
Since this event I’ve begun chewing the enteric coated pills, (now we’re really defeating the purpose, lol) and this has not made any difference. Still not noticing any effect. I’ll swap back to my old brand for a month and see what I think.
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@Ismail oh, and not a totally empty stomach. I took it with 16oz of milk, (but that made sense to me because it’s. Milk protein).
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@evan-hinkle said in Visceral fat reduction by enteric-coated lactoferrin:
@Ismail hey man, doing well! I was taking 500mg Jarrow freeze-dried lactoferrin.
And just a general update: I’ve been taking the enteric coated for a few months now, and I actually think I prefer the ones I was taking before. I replicated the study above taking 300mg of the enteric coated, and really didn’t notice anything at all, (which is odd because I respond to most everything I try, (good or bad)).
TMI: I saw an undigested enteric coated lactoferrin in my stool last week, (great, they’re making it past the stomach-bad, I’m literally shitting my money away…).
Lol! I guess the enteric coating is working erm too well!
Since this event I’ve begun chewing the enteric coated pills, (now we’re really defeating the purpose, lol) and this has not made any difference. Still not noticing any effect. I’ll swap back to my old brand for a month and see what I think.
Yes will def be interesting to see how you respond if you go back again
