Random, interesting studies

Mauritio

Strong pro-sexual effects of Massularia acuminata. Also increases Testosterone on the highest dose.

https://pmc.ncbi.nlm.nih.gov/articles/PMC3022175/#sec3

Increases testosterone, testicular cholesterol and almost triples the testicle- body weight ratio.
https://pubmed.ncbi.nlm.nih.gov/18602232/

Mixed results depending on dosage
https://pubmed.ncbi.nlm.nih.gov/21951198/

Might cause elevation in liver enzymes.
https://www.researchgate.net/publication/375867305_Effects_of_Aqueous_Stem_Extract_of_Massularia_Acuminata_on_Some_Liver_Function_Indices_of_Male_Rats

In this study it seems liver protective

https://visnav.in/ijacbs/wp-content/uploads/sites/3/2021/07/IJACBS-21F-22007-Potentials-of-Massularia-acuminata-stem-bark-extracts-on-Serum-enzymes-and-haematological-parameters-of-aluminium-chloride-induced-toxicities.pdf

Seems safe in lower doses
https://www.researchgate.net/publication/356879871_HAEMATOLOGICAL_BIOCHEMICAL_AND_HISTOLOGICAL_TOXICITY_OF_THE_ETHANOLIC_EXTRACT_OF_MASSULARIA_ACUMINATA_G_DON_BULLOCK_EX_HOLY_RUBIACEAE_STEMS_IN_RAT

Mauritio

Bulbine natalensis

Is another interesting candidate.
Increases testosterone 3-4bfold, lowers estrogen and increases progesterone slightly. Doesn't affect prolactin.
This is only in lower doses (this study 25 /50mg/kg dose) at 100mg/kg it had negative effects.

https://pubmed.ncbi.nlm.nih.gov/19410284/

Might cause some slight atrophy in liver and kidneys, mostly at higher doses.
https://pubmed.ncbi.nlm.nih.gov/19735182/

Completely safe in human males , 28 days, 650mg/d
https://pmc.ncbi.nlm.nih.gov/articles/PMC3500755/

Mauritio

Bees Wax + Policosanol

The alcoholic fraction of Bees wax /honeycomb is policosanol. Here's a threat on policosanols benefits:
https://lowtoxinforum.com/threads/the-policosanols-thread.35360/

Beeswax alcohol (BWA), a mixture of six long-chain aliphatic alcohols (tetracosanol, hexacosanol, octacosanol, triacontanol, dotriacontanol, and tetratriacontanol)

https://pmc.ncbi.nlm.nih.gov/articles/PMC11672924/

I never thought about it like that. Probably pretty silly to not eat the honey comb . Until about 1900 it was common to do that .

How much policosanols is in bees wax / honeycomb?

It seems to be about 1%.
That's a big dose. 100mg from a 10g dose of honey comb/wax .

In this study in German they tested several different bees wax samples from Switzerland, China, Canada and Brasil and they all contained 1% of fattyalcohols (german: "Fettalkohole") .
So a 1% mark of policosanol seems to be globally reliable.

https://sci-hub.ren/10.1002/lipi.19890910207

cs3000

@Mauritio had potential but we cant digest the wax / comb so wouldnt go into system, high in sugarcane wax too , i looked it up if you could extract it by melting the beeswax in hot water. but policosanol form in beeswax is an ester not bioavailable for us until processed / hydrolysed
as a supplement its a good effect on helping lower atherosclerosis without the extra fuckery statins give (and actually shows regression combined with low fat diet) 10mg - 40mg is about the same effect for that (the content of the policosanol matters needs enough octacosanol, and if its ester form probably not absorbed much) (octacosanol is most active part, #3 in https://cs3001.substack.com/p/some-health-finds-3)

Mauritio

@cs3000 Oh damn so close and yet so far
Do you have a source for it beeing indigestible for us ?

Mauritio

For those saying DNP is safe and only careless people die from it.

https://www.ergo-log.com/safe-dnp-cycle-fatal-outcome.html

Mauritio

"This study concludes that the dietary recommendation to avoid consuming coconut oil due to its effects on lipid parameters is not justified,"

https://www.ergo-log.com/coconut-oil-blood-vessels.html

random

@Mauritio said in Random, interesting studies:

@cs3000 Oh damn so close and yet so far
Do you have a source for it beeing indigestible for us ?

@Mauritio @cs3000 i have eaten honey comb multiples Times, a good part of the wax do not melt in the mouth even if you chew it very long, and the part that you swallow often end up as solid flakes in your intestins that cause intestinal irritations and nightmare if you swallow alot. Comb from more recent hives and recently harvested Can be much softer. If you look at hunters gatherers eating honey comb in documentary they spit back the comb. part of beekeepers use plastic/synthetic materials as a base for bees to build the hive on, therefore some honey comb contain a sheet of plastic/synthetic materials in the middle. It is possible you absorb part of what is in the wax, as wax that is colored like orange will end up white/yellowish if you chew it alot even if you dont swallow it

cs3000

@Mauritio
one in dogs vs birds (fig 2 , its not policosanol tho general
fatty acid esters absorbed a little but the fatty alcohol ester didnt https://www.researchgate.net/publication/21739344_Comparative_aspects_of_lipid_digestion_and_absorption_Physiological_correlates_of_wax_ester_digestion

but looked a bit further for specific, rats can digest even more of it if its esterified specific to oleic acid
but thats synthetic esterification not bound with oleic acid normally https://grasasyaceites.revistas.csic.es/index.php/grasasyaceites/article/view/1388 , couldnt find if humans could absorb some but theres a case of a women with gastric blockage who ate a lot of honeycomb so at least a lot goes undigested
https://pmc.ncbi.nlm.nih.gov/articles/PMC2740191/#s02

was still worth posting your post now i know more about it & wouldnt have

@Mauritio said in Random, interesting studies:

for it beeing indigestible for us ?

study from that megathread showing good anti blood clotting property of policosanol https://pubmed.ncbi.nlm.nih.gov/9425618/

cs3000

@cs3000 if its extracted from sugarcane wax its mostly the free form policosanol with high % octacosanol and more digestible https://pubmed.ncbi.nlm.nih.gov/12423895/ maybe 7% as esters in the wax. has b-sitosterol which is anti androgen but <1% of the wax

alfredoolivas

@cs3000 said in Random, interesting studies:

@Mauritio had potential but we cant digest the wax / comb so wouldnt go into system, high in sugarcane wax too , i looked it up if you could extract it by melting the beeswax in hot water. but policosanol form in beeswax is an ester not bioavailable for us until processed / hydrolysed
as a supplement its a good effect on helping lower atherosclerosis without the extra fuckery statins give (and actually shows regression combined with low fat diet) 10mg - 40mg is about the same effect for that (the content of the policosanol matters needs enough octacosanol, and if its ester form probably not absorbed much) (octacosanol is most active part, #3 in https://cs3001.substack.com/p/some-health-finds-3)

Doesn’t the hot water cause hydrolysis ?

Mauritio

Anybody tried bees bread ?

In this study it did wonders for steroid health.
They gave mice on a HFD about 5-7g(HED) of bees bread and it completely rescued the levels of their steroidogenic enzymes.
Not only that, in many cases, giving them bees bread, increased the values above the normal control group.

Testosterone was increased by about 60% above control levels.
StaR mRNA levels doubled !
Unfortunately estrogen was increased as well, but only to the level of the control group not above that.

https://journals.physiology.org/doi/full/10.1152/ajpendo.00093.2021?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

random

@Mauritio said in Random, interesting studies:

Anybody tried bees bread ?

I did, it Can taste much better than basic honey comb that has only wax and honey, basic honey comb is often to acidic and taste aint the best in most case compare to some honey in jar and some beesbread