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    Random, interesting studies

    Literature Review
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    • MauritioM
      Mauritio
      last edited by Mauritio

      Strong pro-sexual effects of Massularia acuminata. Also increases Testosterone on the highest dose.

      https://pmc.ncbi.nlm.nih.gov/articles/PMC3022175/#sec3

      Increases testosterone, testicular cholesterol and almost triples the testicle- body weight ratio.
      https://pubmed.ncbi.nlm.nih.gov/18602232/

      Mixed results depending on dosage
      https://pubmed.ncbi.nlm.nih.gov/21951198/

      Might cause elevation in liver enzymes.
      https://www.researchgate.net/publication/375867305_Effects_of_Aqueous_Stem_Extract_of_Massularia_Acuminata_on_Some_Liver_Function_Indices_of_Male_Rats

      In this study it seems liver protective

      https://visnav.in/ijacbs/wp-content/uploads/sites/3/2021/07/IJACBS-21F-22007-Potentials-of-Massularia-acuminata-stem-bark-extracts-on-Serum-enzymes-and-haematological-parameters-of-aluminium-chloride-induced-toxicities.pdf

      Seems safe in lower doses
      https://www.researchgate.net/publication/356879871_HAEMATOLOGICAL_BIOCHEMICAL_AND_HISTOLOGICAL_TOXICITY_OF_THE_ETHANOLIC_EXTRACT_OF_MASSULARIA_ACUMINATA_G_DON_BULLOCK_EX_HOLY_RUBIACEAE_STEMS_IN_RAT

      Dare to think.

      My X:
      x.com/Metabolicmonstr

      1 Reply Last reply Reply Quote 0
      • MauritioM
        Mauritio
        last edited by Mauritio

        Bulbine natalensis

        Is another interesting candidate.
        Increases testosterone 3-4bfold, lowers estrogen and increases progesterone slightly. Doesn't affect prolactin.
        This is only in lower doses (this study 25 /50mg/kg dose) at 100mg/kg it had negative effects.

        1000014414.png
        https://pubmed.ncbi.nlm.nih.gov/19410284/

        Might cause some slight atrophy in liver and kidneys, mostly at higher doses.
        https://pubmed.ncbi.nlm.nih.gov/19735182/

        Completely safe in human males , 28 days, 650mg/d
        https://pmc.ncbi.nlm.nih.gov/articles/PMC3500755/

        Dare to think.

        My X:
        x.com/Metabolicmonstr

        1 Reply Last reply Reply Quote 1
        • MauritioM
          Mauritio
          last edited by Mauritio

          Bees Wax + Policosanol

          The alcoholic fraction of Bees wax /honeycomb is policosanol. Here's a threat on policosanols benefits:
          https://lowtoxinforum.com/threads/the-policosanols-thread.35360/

          Beeswax alcohol (BWA), a mixture of six long-chain aliphatic alcohols (tetracosanol, hexacosanol, octacosanol, triacontanol, dotriacontanol, and tetratriacontanol)

          https://pmc.ncbi.nlm.nih.gov/articles/PMC11672924/

          I never thought about it like that. Probably pretty silly to not eat the honey comb . Until about 1900 it was common to do that .

          How much policosanols is in bees wax / honeycomb?

          It seems to be about 1%.
          That's a big dose. 100mg from a 10g dose of honey comb/wax .

          1000014477.png

          In this study in German they tested several different bees wax samples from Switzerland, China, Canada and Brasil and they all contained 1% of fattyalcohols (german: "Fettalkohole") .
          So a 1% mark of policosanol seems to be globally reliable.
          1000014481.png

          https://sci-hub.ren/10.1002/lipi.19890910207

          Dare to think.

          My X:
          x.com/Metabolicmonstr

          cs3000C 1 Reply Last reply Reply Quote 0
          • cs3000C
            cs3000 @Mauritio
            last edited by cs3000

            @Mauritio had potential but we cant digest the wax / comb so wouldnt go into system, high in sugarcane wax too , i looked it up if you could extract it by melting the beeswax in hot water. but policosanol form in beeswax is an ester not bioavailable for us until processed / hydrolysed
            as a supplement its a good effect on helping lower atherosclerosis without the extra fuckery statins give (and actually shows regression combined with low fat diet) 10mg - 40mg is about the same effect for that (the content of the policosanol matters needs enough octacosanol, and if its ester form probably not absorbed much) (octacosanol is most active part, #3 in https://cs3001.substack.com/p/some-health-finds-3)

            "world," as a source of new perceptions
            more https://substack.com/@cs3001

            "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

            MauritioM alfredoolivasA 2 Replies Last reply Reply Quote 0
            • MauritioM
              Mauritio @cs3000
              last edited by

              @cs3000 Oh damn so close and yet so far 😄
              Do you have a source for it beeing indigestible for us ?

              Dare to think.

              My X:
              x.com/Metabolicmonstr

              R cs3000C 2 Replies Last reply Reply Quote 0
              • MauritioM
                Mauritio
                last edited by Mauritio

                For those saying DNP is safe and only careless people die from it.

                https://www.ergo-log.com/safe-dnp-cycle-fatal-outcome.html

                Dare to think.

                My X:
                x.com/Metabolicmonstr

                1 Reply Last reply Reply Quote 0
                • MauritioM
                  Mauritio
                  last edited by

                  "This study concludes that the dietary recommendation to avoid consuming coconut oil due to its effects on lipid parameters is not justified,"

                  https://www.ergo-log.com/coconut-oil-blood-vessels.html

                  Dare to think.

                  My X:
                  x.com/Metabolicmonstr

                  1 Reply Last reply Reply Quote 0
                  • R
                    random @Mauritio
                    last edited by random

                    @Mauritio said in Random, interesting studies:

                    @cs3000 Oh damn so close and yet so far 😄
                    Do you have a source for it beeing indigestible for us ?

                    @Mauritio @cs3000 i have eaten honey comb multiples Times, a good part of the wax do not melt in the mouth even if you chew it very long, and the part that you swallow often end up as solid flakes in your intestins that cause intestinal irritations and nightmare if you swallow alot. Comb from more recent hives and recently harvested Can be much softer. If you look at hunters gatherers eating honey comb in documentary they spit back the comb. part of beekeepers use plastic/synthetic materials as a base for bees to build the hive on, therefore some honey comb contain a sheet of plastic/synthetic materials in the middle. It is possible you absorb part of what is in the wax, as wax that is colored like orange will end up white/yellowish if you chew it alot even if you dont swallow it

                    1 Reply Last reply Reply Quote 2
                    • cs3000C
                      cs3000 @Mauritio
                      last edited by cs3000

                      @Mauritio
                      one in dogs vs birds (fig 2 , its not policosanol tho general
                      fatty acid esters absorbed a little but the fatty alcohol ester didnt https://www.researchgate.net/publication/21739344_Comparative_aspects_of_lipid_digestion_and_absorption_Physiological_correlates_of_wax_ester_digestion

                      but looked a bit further for specific, rats can digest even more of it if its esterified specific to oleic acid
                      but thats synthetic esterification not bound with oleic acid normally https://grasasyaceites.revistas.csic.es/index.php/grasasyaceites/article/view/1388 , couldnt find if humans could absorb some but theres a case of a women with gastric blockage who ate a lot of honeycomb so at least a lot goes undigested
                      https://pmc.ncbi.nlm.nih.gov/articles/PMC2740191/#s02
                      8e3275d1-bf2b-4741-b064-61a37927c3a5-image.png
                      was still worth posting your post now i know more about it & wouldnt have

                      @Mauritio said in Random, interesting studies:

                      for it beeing indigestible for us ?

                      👍 🐝

                      study from that megathread showing good anti blood clotting property of policosanol https://pubmed.ncbi.nlm.nih.gov/9425618/

                      "world," as a source of new perceptions
                      more https://substack.com/@cs3001

                      "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

                      cs3000C MauritioM 2 Replies Last reply Reply Quote 0
                      • cs3000C
                        cs3000 @cs3000
                        last edited by

                        @cs3000 if its extracted from sugarcane wax its mostly the free form policosanol with high % octacosanol and more digestible https://pubmed.ncbi.nlm.nih.gov/12423895/ maybe 7% as esters in the wax. has b-sitosterol which is anti androgen but <1% of the wax

                        "world," as a source of new perceptions
                        more https://substack.com/@cs3001

                        "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

                        1 Reply Last reply Reply Quote 0
                        • alfredoolivasA
                          alfredoolivas @cs3000
                          last edited by

                          @cs3000 said in Random, interesting studies:

                          @Mauritio had potential but we cant digest the wax / comb so wouldnt go into system, high in sugarcane wax too , i looked it up if you could extract it by melting the beeswax in hot water. but policosanol form in beeswax is an ester not bioavailable for us until processed / hydrolysed
                          as a supplement its a good effect on helping lower atherosclerosis without the extra fuckery statins give (and actually shows regression combined with low fat diet) 10mg - 40mg is about the same effect for that (the content of the policosanol matters needs enough octacosanol, and if its ester form probably not absorbed much) (octacosanol is most active part, #3 in https://cs3001.substack.com/p/some-health-finds-3)

                          Doesn’t the hot water cause hydrolysis ?

                          cs3000C 1 Reply Last reply Reply Quote 0
                          • MauritioM
                            Mauritio
                            last edited by Mauritio

                            Anybody tried bees bread ?

                            In this study it did wonders for steroid health.
                            They gave mice on a HFD about 5-7g(HED) of bees bread and it completely rescued the levels of their steroidogenic enzymes.
                            Not only that, in many cases, giving them bees bread, increased the values above the normal control group.

                            Testosterone was increased by about 60% above control levels.
                            StaR mRNA levels doubled !
                            Unfortunately estrogen was increased as well, but only to the level of the control group not above that.

                            1000014499.jpg

                            https://journals.physiology.org/doi/full/10.1152/ajpendo.00093.2021?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

                            Dare to think.

                            My X:
                            x.com/Metabolicmonstr

                            R L MauritioM 3 Replies Last reply Reply Quote 0
                            • R
                              random @Mauritio
                              last edited by random

                              @Mauritio said in Random, interesting studies:

                              Anybody tried bees bread ?

                              I did, it Can taste much better than basic honey comb that has only wax and honey, basic honey comb is often to acidic and taste aint the best in most case compare to some honey in jar and some beesbread

                              1 Reply Last reply Reply Quote 0
                              • L
                                lobotomize-me @Mauritio
                                last edited by lobotomize-me

                                @Mauritio honey /most bee products /chyrsin rich foods generally increase testosterone.

                                1 Reply Last reply Reply Quote 1
                                • cs3000C
                                  cs3000 @alfredoolivas
                                  last edited by cs3000

                                  @alfredoolivas said in Random, interesting studies:

                                  Doesn’t the hot water cause hydrolysis ?

                                  apparently too slow by itself so they do extra processing

                                  @Mauritio said in Random, interesting studies:

                                  Anybody tried bees bread ?
                                  In this study it did wonders for steroid health.

                                  nice , & a potent effect really fast in a diabetes model. normalised by 3 days. fastest effect ive seen
                                  STZ model = destruction of pancreas cells so i guess its most relevant to type 1 , or if someone with type 2 has lacking pancreatic islet cells too as part of their problem. full damage was done initially so shows good effect
                                  f7a91ad7-462d-47b0-a878-76e754978cba-image.png
                                  they used an extract ~30mg polyphenols 5mg flavanols per gram so maybe ~ 5g bee bread for 1g of extract
                                  composition varies a lot by location if it was the polyphenols giving most of the effect even in same country by region,
                                  theirs was high in kaempferol-3-O-di-rhamnoside Isorhamnetin-O-hexosyl-O-rutinoside

                                  https://pmc.ncbi.nlm.nih.gov/articles/PMC8264221/#sec7

                                  and if you believe the results,
                                  they showed its acute effect (didnt lower blood sugar when not elevated)
                                  540f89e2-7c50-4a14-9207-30b64b1762b7-image.png
                                  Which is odd. because its not lowering glucose in non diabetic rats so its not acting like insulin right? unless things are effectively counteracting it in the normal group because it would be crashing otherwise from insulin secretion. (at 3hrs in the DW group they had lower blood sugar though 84 vs 92)
                                  unlikely enough islet cells left from the damage to stimulate insulin secretion for such a drastic change in both of the groups, which is what GLB doe? idk maybe there is but they're clearly wrecked from such high glucose at 0hr. 3 hours isnt enough time to regenerate the islet cell damage

                                  "world," as a source of new perceptions
                                  more https://substack.com/@cs3001

                                  "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

                                  alfredoolivasA 1 Reply Last reply Reply Quote 0
                                  • alfredoolivasA
                                    alfredoolivas @cs3000
                                    last edited by

                                    @cs3000 said in Random, interesting studies:

                                    apparently too slow by itself so they do extra processing

                                    Could I finely dice it up and put it in a pot of boiling water for 15 minutes, whilst it remains boiling for the entire 15 minutes? would that be effective?

                                    cs3000C 1 Reply Last reply Reply Quote 0
                                    • cs3000C
                                      cs3000 @alfredoolivas
                                      last edited by cs3000

                                      @alfredoolivas i'd guess it takes a lot longer still but not sure ,
                                      if youre interested in it for the octacosanol sugarcane wax is better only need a little already in a good form https://bioenergetic.forum/post/47406 supplements are around tho

                                      "world," as a source of new perceptions
                                      more https://substack.com/@cs3001

                                      "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

                                      C 1 Reply Last reply Reply Quote 1
                                      • MauritioM
                                        Mauritio
                                        last edited by Mauritio

                                        Again, TLR 4 /Endo­toxin implicated inInfections, not just bac­terial ones, but also viral.

                                        "TLR4-dependent viral entry was further validated by an anti-TLR4 antibody-mediated blocking experiment. It was noticed that TLR4 is necessary for the early events of viral infection, especially during the attachment and entry stages."

                                        https://pmc.ncbi.nlm.nih.gov/articles/PMC10157217/

                                        Endotoxin might not just be implicated in viral entry, but long term consequences of viruses .
                                        The drug larazotide is being researched for long covid symptoms. It basically works in a way that it prevents endotoxin from entering circulation .

                                        https://ichgcp.net/de/clinical-trials-registry/NCT05747534

                                        Dare to think.

                                        My X:
                                        x.com/Metabolicmonstr

                                        1 Reply Last reply Reply Quote 0
                                        • MauritioM
                                          Mauritio @cs3000
                                          last edited by

                                          @cs3000 said in Random, interesting studies:

                                          @Mauritio
                                          one in dogs vs birds (fig 2 , its not policosanol tho general
                                          fatty acid esters absorbed a little but the fatty alcohol ester didnt https://www.researchgate.net/publication/21739344_Comparative_aspects_of_lipid_digestion_and_absorption_Physiological_correlates_of_wax_ester_digestion

                                          but looked a bit further for specific, rats can digest even more of it if its esterified specific to oleic acid
                                          but thats synthetic esterification not bound with oleic acid normally https://grasasyaceites.revistas.csic.es/index.php/grasasyaceites/article/view/1388 , couldnt find if humans could absorb some but theres a case of a women with gastric blockage who ate a lot of honeycomb so at least a lot goes undigested
                                          https://pmc.ncbi.nlm.nih.gov/articles/PMC2740191/#s02
                                          8e3275d1-bf2b-4741-b064-61a37927c3a5-image.png
                                          was still worth posting your post now i know more about it & wouldnt have

                                          @Mauritio said in Random, interesting studies:

                                          for it beeing indigestible for us ?

                                          👍 🐝

                                          study from that megathread showing good anti blood clotting property of policosanol https://pubmed.ncbi.nlm.nih.gov/9425618/

                                          Seems right. For some reason birds seem to be good at it. Humans not. Such a shame.

                                          And interesting studies you posted on Bee bread. Quite the strong effect indeed.

                                          Dare to think.

                                          My X:
                                          x.com/Metabolicmonstr

                                          1 Reply Last reply Reply Quote 0
                                          • MauritioM
                                            Mauritio
                                            last edited by Mauritio

                                            Im not convinced that low protein is dangerous and catabolic, mid - long term in people under 65.

                                            I recently posted a study showing 5 weeks of 8% protein in the diet did not cause muscle loss. After which someone said that isnt long enough .

                                            Now here's a study showing that 12 weeks of a very low 0.4g/kg/d, ~5%protein diet does not lower basal muscle protein synthesis!
                                            https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0137183

                                            It seems to come down to age as well.
                                            Here it gets interesting: if you're under 65 and eating a high protein diet, that is strongly associated with death, cancer and diabetes . Over 65 it seems to be protective !

                                            "...aged 50–65 reporting high protein intake had a 75% increase in overall mortality and a 4-fold increase in cancer and diabetes mortality..."
                                            https://pmc.ncbi.nlm.nih.gov/articles/PMC3988204/

                                            Not sure why. Low protein diets can lead to lower thymus weight, as seen in this study (https://www.scielo.br/j/bjmbr/a/MGBdr7CsJTMQrf7Bhjbdv3z/?lang=en)
                                            And older people are more susceptible to infections and chronic inflammation .So maybe after 65 the increase
                                            in Protein and inflammatory amino acids is worth the trade off, for increased immunity and suppression of inflammation .
                                            Maybe it's simply the lesser of 2 evils at that point .
                                            What do you guys think?

                                            Dare to think.

                                            My X:
                                            x.com/Metabolicmonstr

                                            LucHL DavidPSD alfredoolivasA 3 Replies Last reply Reply Quote 1
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