Dandruff or scalp irritation? Try BLOO.

  • Categories
  • Recent
  • Tags
  • Popular
  • Users
  • Groups
  • Register
  • Login
Bioenergetic Forum
  • Categories
  • Recent
  • Tags
  • Popular
  • Users
  • Groups
  • Register
  • Login

Repairing Knee Osteoarthritis and Cartilage Degeneration with the combination of Boswellia and Celery Seed:

Literature Review
4
11
271
Loading More Posts
  • Oldest to Newest
  • Newest to Oldest
  • Most Votes
Reply
  • Reply as topic
Log in to reply
This topic has been deleted. Only users with topic management privileges can see it.
  • D
    DavidPS
    last edited by May 6, 2025, 8:51 PM

    Apigenin from daily vegetable celery can accelerate bone defects healing (2019)

    ““Effective health care depends on self-care” - Ivan Illich, 👀
    ☂️

    1 Reply Last reply Reply Quote 0
    • D
      DavidPS
      last edited by May 6, 2025, 9:04 PM

      Here is the horse study.

      Clinical Effects of the Extract of the Seeds of the Indian Celery—Apium graveolens—In Horses Affected by Chronic Osteoarthritis (2019)

      Figure 1. Box-plots of score change at time 0 and after 59 days for the parameters ’amplitude of passive flexion’ (A) (median of the Control group 0.0 with a range between −2.0 and 0.0, median of Group B 1.0 with a range between 0.5 and 2.0), ’sensitivity to passive flexion’ (B) (median of the Control group 0.0 with a range between −2.0 and 0.0, median of Group B 1.0 with a range between 0.5 and 2.0) and ’flexion test’ (C) of horses treated with 30 g BID CSE (Group B) (median of the Control group 1.0 with a range between −5.0 and 2.25, median of Group B 5.0 with a range between 4.75 and 5.25), and controls. The asterisk indicates p < 0.05.
      Animals 09 00585 g001

      2689aa4d-a005-4201-a209-e8f9bdc43545-image.png

      ““Effective health care depends on self-care” - Ivan Illich, 👀
      ☂️

      1 Reply Last reply Reply Quote 0
      • L
        LucH
        last edited by May 6, 2025, 9:32 PM

        I've got this information on my PC:
        Boswellia and Inflammation
        Boswellic acid has an impact on:
        PGE (cox1 & 2 + Lox-5)
        Cytokine (IL-1B)
        NK-kB (The nuclear factor NF-κB pathway)
        NO (nitric oxide)
        HLE (human leukocyte elastase)

        NB: 3 - 500 mg boswellic extract 2 or 3x/d. If 30 to 40 % extract.

        The extract of Boswellia serrata, a plant widely used in the treatment of joint inflammation in Ayurvedic medicine, contains an active component, beta-boswellic acid, which can inhibit 5-lipoxygenase, the key enzyme in leukotriene biosynthesis. In addition to inhibiting Lox-5 and blocking the biosynthesis of dangerous inflammatory leukotrienes, boswellic acid decreases the activity of another pro-inflammatory enzyme, HLE (human leukocyte elastase). HLE is associated with rheumatoid arthritis and respiratory diseases such as pulmonary emphysema, chronic bronchitis, and acute respiratory distress syndrome. In many inflammatory diseases, both leukotriene and HLE levels are elevated. Boswellic acid currently appears to be one of the only substances capable of inhibiting both leukotrienes and HLE (5).
        Thirty subjects with knee osteoarthritis participated in a 16-week randomized, double-blind, placebo-controlled study. All those taking a supplement containing boswellia extract reported reduced pain and swelling, increased knee flexion, and the ability to walk longer distances. (6)
        Source: nutranews
        http://www.nutranews.org/sujet.pl?id=972 (In French)

        NB: If you block one pathway, repeatedly or habitually, the body will eventually bypass the problem, and the inflammation will find another way in.
        Therefore, we must address both the causes and more respectful means. By more respectful means, I mean promoting the natural pathways for metabolizing eicosanoids (very long-chain fatty acids, such as EPA, DHA, and GLA), which naturally combat cycloxygenases and 5-lipoxygenases (Cox and Lox).
        => Not too long. Do not block the same access route for too long. It is necessary to alternate PGE 1 / PGE 3 moderation and reduce stimulation.

        C D 2 Replies Last reply May 6, 2025, 9:43 PM Reply Quote 1
        • C
          CrumblingCookie @LucH
          last edited by CrumblingCookie May 6, 2025, 9:47 PM May 6, 2025, 9:43 PM

          Beside lowering Nf-kB etc., the celery extract mostly but not exclusively contains apigenin so there could be epigenetic cellular reactivation through HDAC-inhibition.
          Both celery extract and apigenin, and flavonoids in general (?), seem to promote breakdown of calcium oxalate. Which is of course a significant factor with regard to maintaining or building bones but also to dissolving kidney stones. They seem to free up and excrete renal calcium from calcium-oxalate calculi. If the same happens in upstream bodily tissues there should be more calcium re-availability for the bone matrix as well as a reduction in soft-tissue calcification. I.e. a return to better joint and cartilage functions with reduced pain and building of bone.
          Anticalculi Activity of Apigenin and Celery (Apium graveolens L.) Extract in Rats Induced by Ethylene Glycol–Ammonium Chloride

          D 2 Replies Last reply May 7, 2025, 10:02 AM Reply Quote 1
          • D
            DavidPS @LucH
            last edited by May 7, 2025, 9:54 AM

            @LucH - Thanks, it is useful to know. I have never had a need to try boswellia.

            ““Effective health care depends on self-care” - Ivan Illich, 👀
            ☂️

            1 Reply Last reply Reply Quote 0
            • D
              DavidPS @CrumblingCookie
              last edited by May 7, 2025, 10:02 AM

              @CrumblingCookie - I get my apigenin from dried parsley. I have been liberally sprinkling it on my food for at least 3 years. I use it for forestall mitochondrial dysfunction, For the details, here the thread.
              https://lowtoxinforum.com/threads/cd38-dictates-age-related-nad-decline-and-mitochondrial-dysfunction-through-an-sirt3-dependent-mechanism.45394/

              ““Effective health care depends on self-care” - Ivan Illich, 👀
              ☂️

              C 1 Reply Last reply May 8, 2025, 11:53 AM Reply Quote 0
              • C
                cs3000 @DavidPS
                last edited by cs3000 May 7, 2025, 3:57 PM May 7, 2025, 2:44 PM

                @DavidPS
                👍
                Great one
                has a big conflict of interest with funding but theres extra support here (not declared as a conflict but another brand supplied, korean tho so separate locations) https://www.mdpi.com/1422-0067/25/6/3218
                8f15794b-08de-4942-acd8-c738ce3f13c5-image.png

                regen marker
                1fb0faa0-8e31-4f76-b4b8-f3564399a7c8-image.png

                a0c74b0c-01e2-45aa-a86d-2f76c6c56dbb-image.png

                in the boswellia capsule 300mg
                a7132257-af5b-4f63-bc83-134e466d5d3d-image.png
                in the celery capsule 250mg
                70e03020-4ff2-4264-96f3-4770655393f8-image.png

                "world," as a source of new perceptions
                more https://substack.com/@cs3001

                "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

                C 1 Reply Last reply May 8, 2025, 10:28 AM Reply Quote 0
                • C
                  cs3000 @cs3000
                  last edited by cs3000 May 8, 2025, 11:32 AM May 8, 2025, 10:28 AM

                  @cs3000 said in Repairing Knee Osteoarthritis and Cartilage Degeneration with the combination of Boswellia and Celery Seed::

                  in the boswellia capsule 300mg
                  a7132257-af5b-4f63-bc83-134e466d5d3d-image.png
                  in the celery capsule 250mg
                  70e03020-4ff2-4264-96f3-4770655393f8-image.png

                  ~100mg acids is where the benefits are at but theres a study in animals where 0.1% diet of this with 30% acids made colitis worse (like 1g of a 30% extract- and thats spaced apart in diet too)
                  only for the initial damage though, recovery was still there and from a higher amount so i think it still shows accelerated recovery.
                  but the initial higher damage is there. maybe its specific to the way its induced with DSS.
                  https://sci-hub.ru/10.1152/ajpgi.00433.2004

                  small amounts spaced apart 300mg * 3 of one with only ~10% acids gave a great effect in humans with colitis https://sci-hub.ru/10.1055/s-2001-15802
                  (if someone has gut issues , just to be on safer side maybe a good idea to split the dose and avoid high extract % / high dose supplements giving 200mg+ a pill)

                  "world," as a source of new perceptions
                  more https://substack.com/@cs3001

                  "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

                  1 Reply Last reply Reply Quote 2
                  • C
                    CrumblingCookie @DavidPS
                    last edited by May 8, 2025, 11:53 AM

                    @DavidPS said:

                    I get my apigenin from dried parsley. I have been liberally sprinkling it on my food for at least 3 years.

                    Parsley is great! Chives too. I finally pour them generously on my foods too after I've eventually come around to looking for and buying them in bulk online (cut & dried). The local stores simply don't have them.

                    1 Reply Last reply Reply Quote 1
                    • D
                      DavidPS @CrumblingCookie
                      last edited by May 9, 2025, 2:40 PM

                      @CrumblingCookie said in Repairing Knee Osteoarthritis and Cartilage Degeneration with the combination of Boswellia and Celery Seed::

                      Both celery extract and apigenin, and flavonoids in general (?), seem to promote breakdown of calcium oxalate.

                      Digging into this I discovered the term Chondroprotective agents. These agents "include both endogenous and synthetic chemicals." No mention of exogenous natural sources. A quick search of 2025 pulbications:

                      Anthocyanins and Anthocyanidins in the Management of Osteoarthritis: A Scoping Review of Current Evidence

                      Potential Chondroprotective Effect of Artemisia annua L. Water Extract on SW1353 Cell

                      Chondroprotective effect of pomegranate seed oil in papain-induced knee osteoarthritis through animal modeling

                      ““Effective health care depends on self-care” - Ivan Illich, 👀
                      ☂️

                      1 Reply Last reply Reply Quote 0
                      • 1 / 1
                      1 / 1
                      • First post
                        11/11
                        Last post