Random, interesting studies

[Mauritio]

@Mauritio said in Random, interesting studies:

Anybody tried bees bread ?

In this study it did wonders for steroid health.
They gave mice on a HFD about 5-7g(HED) of bees bread and it completely rescued the levels of their steroidogenic enzymes.
Not only that, in many cases, giving them bees bread, increased the values above the normal control group.

Testosterone was increased by about 60% above control levels.
StaR mRNA levels doubled !
Unfortunately estrogen was increased as well, but only to the level of the control group not above that.

https://journals.physiology.org/doi/full/10.1152/ajpendo.00093.2021?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

I was wondering where the strong androgenic effect from this study was coming from, it seemed hard to believe that it was only from an antioxidant effect.

I think I found the answer.
IL-10 has been shown to be responsible for the 5-10x increase in Testosterone from L. Reuteri in animal studies.
https://bioenergetic.forum/topic/2188/l-reuteri/50?_=1747639248664

And bee bread drastically increased Il-10 in this study.

Compared to the control group the mrna increased about 10x and compared to the obese high fat group probably 30x . So that might be part of the androgenic effect.

I took 2.5g yesterday and today my muscle look insanely full, also notice higher libido and drive.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8868291/#sec3-antioxidants-11-00255

[Mauritio]

Butyrate increases SERT more than two fold and lowers expression of various serotonin receptors in this study.
Only in vitro but still another win for butyrate .

https://pubmed.ncbi.nlm.nih.gov/37240731/#:~:text=As part of its function,gut–brain axis%3B serotonin.

[Mauritio]

Trehalose strongly increases thermogenesis in this study.
Mechnism: increase in FGF21 ,PPAR-a, UCP1 etc.

https://pubmed.ncbi.nlm.nih.gov/29996716/

It increases life span in worms:
"... extended the mean life span by over 30% without any side effects. Surprisingly, trehalose treatment starting even from the old-adult stage shortly thereafter retarded the age-associated decline in survivorship and extended the remaining life span by 60%."

And healthspan as well:
"...trehalose increased the reproductive span and retarded the age-associated decrease in pharyngeal-pumping rate and the accumulation of lipofuscin autofluorescence. Trehalose also enhanced thermotolerance and reduced polyglutamine aggregation."
https://pubmed.ncbi.nlm.nih.gov/20477758/

"Trehalose attenuates testicular aging by activating autophagy and improving mitochondrial quality"
https://pubmed.ncbi.nlm.nih.gov/39195433/

It lowers lipogenesis in the liver and increases PPARa, AMPK and SIRT1.
https://pubmed.ncbi.nlm.nih.gov/37581638/

Ray Peat on trehalose:

From a GE episode:

Q: "And does the mushroom sugar, is it called trehalose? Does that contributes to the functioning of the organism?"

A: "Yeah, that’s a stabilizing thing that opposes endotoxin. There’s been good research showing that there seems to be a direct structural effect of trehalose defending the cytoplasm against the disorganizing. There’s been good research showing that there seems to be a direct structural effect of endotoxin. And that’s kind of a metaphor for everything that’s happening, stressful in the organism.
And trehalose is one of the stabilizers that the progesterone, cholesterol, lanosteroids are another level or type of stabilizer."

[Wabi-sabi]

@Mauritio If using for BAT activation then you would need to reduce Fructose and Sucrose........Seems difficult IDK

[Mauritio]

@Wabi-sabi Why?

[Wabi-sabi]

@Mauritio No weight loss, shooting yourself in the foot, so to speak IDK.

[Mauritio]

@Wabi-sabi how much trehalose are you speaking of here?
Don't think youre gonna gain much weight from a few grams especially when it increases metabolism via uncoupling...

[Wabi-sabi]

@Mauritio Sorry I haven't tried it, are you thinking of trying, or have done so, experiments can be fun though

[Mauritio]

@Wabi-sabi Im not sure how much other people take that's why im asking.
The first study I posted comes down to an HED of 20-30g , so still doable . If you're concerned about calories, you could replace it for the sugar in your milk or coffee.

I took 3.5g today and it seemed to have a gut cleansing effect , sustained clean energy. Less brain fog.
Actually made me a bit hypoglycemic from what i felt like , probably the increase in metabolism. So taking it with a meal should help.
My face also looks better/younger. IIRC it's used in cosmetics because it has a filling effect.
Not bad.

[Wabi-sabi]

@Mauritio @yerrag Yep, used in cosmetics, good stuff, and yerrag I thought of you and Parkinson's and the following;

Autophagy Activation
Trehalose stimulates autophagy, the cellular process that clears out damaged proteins and organelles.
Early days in research though.