vitamin K2 MK7 instead of MK4 for ulcers from aspirin, does it really matter that much

LucH

@hwisdom said in vitamin K2 MK7 instead of MK4 for ulcers from aspirin, does it really matter that much:

I tried my aspirin protocol without vit K2, actually felt great and didnt get any headaches nor nose bleeds nor any of that zero negatives, its just that Ive been seeing dark spots in my stool which is indicative of bleeding up the upper tract where my gut ends up digesting the leaking blood, my stomach did also kinda feel like it wasn't acidic enough.

Hi,
Listen to your symptoms.
What I would do, in this order:

Stop for a while aspirin.
Need some L-glutamine 1/4 tsp 2x/d but not without taurine to avoid problems with the glutamate pathway. You need glutamine when suffering from leaky gut and the thickness of mucin (stomach coat). You probably lack B6 too (20-25 mg), when there are stress and inflammation. Easier to reach the the brain too with B6 (stress).
You need K1 from veggies
I take MK4 too. 1 mg ( 1000 mcg) with breakfast when there enough fat (25 - 33 g optimal). Not cheap but it lasts one year minimum (Thorn Research). no need to take more than 2 mg (2 000 mcg). I can give a link from studies to explain why.
NB: I would delegate to someone I trust if you're unsure what to think. Otherwise, you'll secrete cortisol and disrupt the recovery staple.
=> Need bisglycinate Mg, L-theanine to calm down. Or you try EFT or sophrology technic.
Once a week I take a mix with K1 K2 MK4 and MK7. Cheap. life Extension super K. High level K1. So not every day.
I'd take white willow bark extract (15 % salicin titrated) instead of aspirin. I can give a link on my forum (in French) if interested about details (why). Swanson 500 mg. 3 weeks cure, 12-15 days stop (to renew platelets).
Aspirin surppresses the making of new platelets. You need platelet for blood aggregation.

alfredoolivas

@LucH share the link to french forum plz

hwisdom

@LucH thank you for ur contribution man I did already stop taking aspirin, and I would love to read more about why using willow park extract is better, I already have a couple of good ideas as to why is it maybe because the amount of aspirin converted from salicin is only dependant on what ur liver can handle + its not irritating on stomach?

LucH

@alfredoolivas and @hwisdom
Why you should give a try with WWB.
We’re not talking about a crisis drug stuff. Since ASA (acid acetyl-salicylic) has an impact on platelet aggregation (for sure) and a possible by-side effect on mucin (epithelial protection of the linen intestinal walls) (aggressive and disruptive), we should learn how to manage to minimize the contraindications’ from these molecules.
I’ll give the direction where we should look at, not in details now.
There is an impact of ASA on platelets, and thus blood fluidity. Possible interaction with liposoluble vitamins?

Useful links on ASA & WWB

*) Impact of HD aspirin on platelet aggregation curve
https://mirzoune-ciboulette.forumactif.org/t2143-english-corner-impact-of-hd-aspirin-on-platelet-aggregation-curve?highlight=platelet

*) English corner: Aspirin cuts the spark; vitamin K keeps the current steady.
https://mirzoune-ciboulette.forumactif.org/t2144-english-corner-aspirin-cuts-the-spark-vitamin-k-keeps-the-current-steady#30424
Prevention for SARS-cov-2.

Vitamin K does not trigger clotting, it only ensures that the clotting and anti-clotting systems work effectively. Vitamin K is an essential cofactor for the activation of several proteins.
How MK-4 aids in redox recovery
Does aspirin counteract GLA protein or osteocalcin?
HD Aspirin take permanently inhibits existing platelets; recovery depends on new platelet formation (≈ 10 days). Whatever the dosage is (81, 325 or > 500-1000 mg ASA).
Vit K enhances balance: Vit K is an essential cofactor for the activation of several proteins.

*) Aspirin & Salicin from White Willow Bark – A Natural Path to Mitochondrial Vitality?
https://mirzoune-ciboulette.forumactif.org/t2128-english-corner-aspirin-salicin-from-white-willow-bark-a-natural-path-to-mitochondrial-vitality

NB: I'll begin with this new post:
Salicin and WWB Talk with Gemini 3
https://mirzoune-ciboulette.forumactif.org/t2163-salicin-from-wwb-vs-aspirin#30570
Context
Once salicin from WWB is converted (via hydrolysis and oxidation) into salicylic acid, it can interact with cellular energy systems in a few notable ways; often on a more mildly way.

Uncoupling of Oxidative Phosphorylation (Mild effect and Adaptive).
Inhibition of Mitochondrial Stress Signaling (NF-κB, TNF-α).
Protection against Lipid Peroxidation.
Stimulation of Pyruvate Utilization (no direct data, mildly apply) DOI:10.1136/jcp.54.7.553
Downregulation of iNOS and NO Overload (it supports mitochondrial longevity and cleaner respiration).

Excerpt
Salicin is hydrolyzed into saligenin (salicyl alcohol) and d-glucose in the intestines, primarily by gut bacteria (or enzymes). Saligenin is then absorbed into the blood and transported to the liver, where it is oxidized to form salicylic acid, the active compound with anti-inflammatory and pain-relieving properties.
https://www.stanfordchem.com/salicin-vs-salicylic-acid-relationship-difference-uses.html

hwisdom

@LucH thank you very cool very nice very awesome

hwisdom

@LucH but yea my actual question was about the efficasy of mk7 and if its good enough to activate the clotting factors that are shut down by aspirin

hwisdom

https://pubmed.ncbi.nlm.nih.gov/34115006/ nvm wow it actually doesnt this is crazy is mk7 that fucking useless? it doesnt even affect bones or hormones damn bru

alfredoolivas

@hwisdom 90 micrograms is really low dose

sunsunsun

This post is deleted!

engineer

@alfredoolivas why do normie supplements always have these tiny k2 doses? Even Kuinone is 2000ug per drop

hwisdom

@alfredoolivas good point but mk7 apparently is like more active or smth??