vitamin K2 MK7 instead of MK4 for ulcers from aspirin, does it really matter that much
-
@hwisdom 90 micrograms is really low dose
-
This post is deleted! -
@alfredoolivas why do normie supplements always have these tiny k2 doses? Even Kuinone is 2000ug per drop
-
@alfredoolivas good point but mk7 apparently is like more active or smth??
-
@hwisdom said in vitamin K2 MK7 instead of MK4 for ulcers from aspirin, does it really matter that much:
my actual question was about the efficasy of mk7 and if its good enough to activate the clotting factors that are shut down by aspirin
Vitamin K and Clotting
Vitamin K could perhaps be considered as a facilitator
High levels of vitamin K ensure that the circulation system can function effectively, as K activates anti-coagulation proteins. Vitamin K does not trigger clotting, it only ensures that the clotting and anti-clotting systems work effectively.
Both of these systems depend on sufficient amounts of vitamin K being available. Vitamin K does not initiate the formation of a blood clot, nor does it resolve or dissolve a clot. However, vitamin K does improve the functioning of both these systems. The key role of vitamin K is to make sure these systems work effectively.
The risk of unnecessary clots is increased when there are low amounts of vitamin K. A right amount Vitamin K is required to enhance balance between clotting and clotting factors (aka a balance between pro-coagulant (clot-forming) and anticoagulant (clot-inhibiting). A deficiency leads to a shortage of these factors, resulting in an increased risk of bleeding and bruising from minor injuries.
Source: https://www.k-vitamins.com/index.php?page=research-view-all&id=16 -
@engineer @hwisdom <200mcg is the average intake of vitamin K2, that's why they are dosed so low.
MK7 is a precursor to MK4, and produces much more stable levels compared to an equivelent dose of MK4. Though the other MKs including 4 are much more active than MK 7. Though MK7 does have some binding affinity to the PXR receptor ("vitamin K receptor"), MK4 has much higher binding affinity
-
@alfredoolivas said in vitamin K2 MK7 instead of MK4 for ulcers from aspirin, does it really matter that much:
MK7 is a precursor to MK4, and produces much more stable levels compared to an equivelent dose of MK4.
I suppose we aren't speaking about the shelve life of liquid forms, once the bottle is opened.
Stable?
MK7 has a longer tail and can move faster / easier.
=> I suppose you mean MK7 half-life is longer in the body.- MK 7 (or any blend with PUFAs) is much more susceptible to oxidation (related to double bonds). This is why its shelf life after opening is shorter (~3 months).
Useful info for other readers. Only if you can easily summarize, know your target (brain / bone / vessels). Otherwise, you'll get lost.
- Stability of K2 MK4(shelve life) + How I manage (many interesting links). The post is in French (translator required) but most of the links re in English.
- Chris Masterjohn about vitamin K: see the graph.
Vit MK4 Vs MK7 Masterjohn
They have different effects because of their chemical structure differences and thus the way they are “packaged” into chylomicrons in the intestine. Have you read https://chrismasterjohnphd.com/blog/2016/12/09/the-ultimate-vitamin-k2-resource/? When vitamin K gets “packaged” up in a chylomicron, mk4 is on the outer edges of the chylomicron and mk7 is in the center.
-
@alfredoolivas do you think it happens at sufficient levels where mk7 doesnt cause problems? Im tryna take 4g of aspirin per day rn
-
@hwisdom Aspirin thins the blood by inhibiting COX enzymes and Vitamin K thickens the blood by increasing clotting factors, dependent on vitamin K.
Aspirin affects platelet function. Vitamin K affects coagulation protein activation. So I don't think they would counteract eachother. Though 4 grams a day isn't that risky (on it's own). Just make sure to not get into any traumatic accidents, because the bleeding greatly increases risk of hemmorhage, potentialy leaving you brain dead.
So walk & drive safe (to not end up like Michael Schumacher), be careful lifting weights and be careful skiing/snowboarding in sweden. No fighting too -
@alfredoolivas like Ik all of this but im just asking, I have a bag of mk7 that I dont wanna use bcus of its negative effects compared to k1 and mk4, im gonna be needing to take a massive amount of mk7 and more than 150mcg ish has been shown in some cases to be problematic and if Im gonna be taking 4g of aspirin my needs of vit K will go up to the point where this small dose aint enough, but Im just not sure about this whole mk7 thing atp so this is why im asking
