Melanotan II log
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This is my log for the melanotan II peptide. I ordered a HUGE amount of it from peptaura.com (20x 10mg vials from Reta Peptide [now Retalux] and Welon [now Lumira]) so it should last at least a couple years.
So why melanotan II? Turns out MT2 is pretty Peaty:
- It increases insulin-independent muscle glucose uptake by increasing GLUT (note that it also increases FAO, which isn't Peaty)
- It potentiates androgens such as testosterone (https://bioenergetic.forum/topic/9088/microgram-doses-of-melanotan-ii-may-increase-the-androgenic-effects-of-testosterone)
- It suppresses appetite, which is Peaty if you're trying to eat less without having hunger cause a stress response
- It increases libido potentially by modulating dopamine levels and thus lowering prolactin, but this is currently not proven and only my speculative reasoning
Oh, and like the name suggests, it gives you a tan much easier than doing it with sunlight alone. All of these effects arise from MC receptor agonism.
Day 0:
I did 0.2mg-0.25mg (there was an air bubble in the syringe). Nothing felt or seen, not even anything at the injection site.
Day 1:
I spent 20 minutes walking topless in the sun after having done 0.25mg a few hours earlier. No tan yet, but maybe increased libido a little. It's a lot easier for me to get satiated eating even sugary liquids like OJ.
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Get a load of these Peaty MT2 studies:
Antidepressant-like and antistress effects of the ACTH(4–10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress
https://www.sciencedirect.com/science/article/pii/S0014299924007581
"We found that chronic treatment with Semax and MTII reversed or substantially attenuated CUS-induced anhedonia, BW gain suppression, adrenal hypertrophy and a decrease in the hippocampal levels of BDNF... Our findings show that in the CUS paradigm, systemically administered ACTH(4–10) analogs Semax and MTII exert antidepressant-like effects on anhedonia and hippocampal BDNF levels, and attenuate markers of chronic stress load, at least in male rats. The results support the argument that ACTH(4–10) analogs and other noncorticotropic melanocortins may have promising therapeutic potential for the treatment and prevention of depression and other stress-related pathologies."
Melanotan-II reverses memory impairment induced by a short-term HF diet
https://www.sciencedirect.com/science/article/pii/S0753332223009204
"A high-fat (HF) diet has been shown to increase the risk of neurological impairments and neurodegenerative disorders. The melanotropins used in this study have been associated with diet-related disorders; however, there is an absence of studies on their effect on diet-induced neurobehavioral conditions. Here, we investigated the possible relationship among diet, Melanotan-II (MT-II) targeting melanotropin receptors, and the behavior of zebrafish (Danio rerio). Surprisingly, even a short-term HF diet lasting for ∼ 1 % of the zebrafish's life had a strong developmental effect. Zebrafish fed the HF diet showed an impairment in recognition memory, elevated anxiety levels, and reduced exploratory propensity after just three weeks compared to zebrafish fed the control diet. These HF diet-induced abnormalities were reversed by MT-II. Animals fed a HF diet and treated with MT-II demonstrated recognition memory, anxiety, and exploratory behavior similar to the control group. This study provides evidence that even a short-term HF diet has an impact on memory and emotions and is the first study to show that MT-II reverses these changes."
