I invented a drug combination to significantly increase free testosterone without any side effects.
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@alfredoolivas Effects of therapeutic doses of dutasteride on neurosteroids aren't clear, because of it's low ability to pass BBB. Some studies suggest it may increase neurosteroids in the brain, including allopregnanolone by decreasing conversion of progesterone into it in the peripheral circulation.
Is Dutasteride a Therapeutic Alternative for Amyotrophic Lateral Sclerosis?
https://www.mdpi.com/2227-9059/10/9/2084/pdf?version=1661512755
Data exists regarding other mechanisms of neuroprotection by dutasteride, such as protection of dopaminergic neurons.
LINCS Dataset-Based Repositioning of Dutasteride as an Anti-Neuroinflammation Agent
https://www.mdpi.com/2076-3425/11/11/1411
Peripheral Neuroprotective and Immunomodulatory Effects of 5α-Reductase Inhibitors in Parkinson’s Disease Models
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.898067/full
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@LunaticRed Yes but Neurosteroids cross the BBB. Peripheral reduction will decrease Brain levels. If you reduce progesterone's metabolism, that won't mean substantially more gets into the brain. The brain can't do all the converison.
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@alfredoolivas
In this study, only doses of 2.5mg of dutasteride (which is far more than needed to suppress 90% of DHT) showed significant reduction in serum allopregnenalone, which actually resulted in positive cognitive effects.5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder
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@LunaticRed said in I invented a drug combination to significantly increase free testosterone without any side effects.:
In this study, only doses of 2.5mg of dutasteride (which is far more than needed to suppress 90% of DHT) showed significant reduction in serum allopregnenalone, which actually resulted in positive cognitive effects.
Of course, inhibiting inhibtory hormones like allopregnenolone would increase coginiton. If you inhibit adenosine (an inhibitory molecule) via caffeine you too get increased cognition. That doesn't mean it is good for you.
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@alfredoolivas Depends on your goals.
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@LunaticRed That is true, but a totally different topic. There are much more tested methods to improve coginition via "unhealthy" pathways, such as modafinil and viagra.
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@LunaticRed
What exactly would those goals be?I'm lost on why one would want to increase free test, but have a significant portion of that not convert to DHT.
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@sphagnum So that you can have all the benefits caused by testosterone (anabolism. energy) and none of negatives associated with DHT (benign prostatic hyperplasia, male pattern baldness, cardiac remodeling and fibrosis). The only benefit of DHT is aromatase inhibition, but you will inhibit aromatase by proviron using this combination.
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@LunaticRed why are you on this forum if you believe the only benefit of dht is aromatase inhibition? I think you have a meager understanding of dht, testosterone and duasteride.
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@risingfire What other benefits DHT has that testosterone doesn't?
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@LunaticRed DHT metabolites are neurosteroids and are stronger calcium channel blockers than T
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@LunaticRed what @alfredoolivas said along with inhibiting cortisol, positive androgenic effects like increased strength, bone growth, anti-anxiolytic, controls blood sugar, controls inflammation from endotoxin. The list goes on. In reality, it is the TRUE male hormone.
