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    The anti-cortisol mechanism of trenbolone

    Scheduled Pinned Locked Moved Literature Review
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    • engineerE Offline
      engineer
      last edited by

      What is the safety profile of a tiny amount, say 3mg a day or 25mg a week? You still have that AR and PR agonism to deal with.

      alfredoolivasA 1 Reply Last reply Reply Quote 1
      • alfredoolivasA Offline
        alfredoolivas @engineer
        last edited by

        @engineer it’s been safe in animal models of less than 200mg a week.
        No hospital case reports of anyone taking less than 100mg.
        A guy took 25mg orally for a few weeks and got liver issues but I doubt he was intaking trenbolone, but another oral steroid.

        1 Reply Last reply Reply Quote 1
        • alfredoolivasA Offline
          alfredoolivas
          last edited by

          Tren implants increase testosterone and progesterone
          d2b29223-3bdc-4953-9f8d-8ec86101c670-image.png
          https://pubmed.ncbi.nlm.nih.gov/573255/

          engineerE 1 Reply Last reply Reply Quote 0
          • engineerE Offline
            engineer @alfredoolivas
            last edited by

            @alfredoolivas ok, so if low dose tren can even increase T and P4, why are these bodybuilders using huge amounts and shutting themselves down?

            alfredoolivasA 1 Reply Last reply Reply Quote 0
            • alfredoolivasA Offline
              alfredoolivas
              last edited by alfredoolivas

              82597122-f42d-4f60-81c5-e09c84883472-image.png

              Increases conversion of tryptophan into kynurenine pathway. Possibly reducing serotonin. Decreased catabolism too
              http://pubmed.ncbi.nlm.nih.gov/40858/

              HED: 0.13mg/kg TBA a day.

              alfredoolivasA 2 Replies Last reply Reply Quote 1
              • alfredoolivasA Offline
                alfredoolivas @alfredoolivas
                last edited by

                5904665a-1a48-4a5b-adb7-59dcac88d37d-image.png

                Methyl Tren increases fertility of females.
                https://pubmed.ncbi.nlm.nih.gov/528432/#:~:text=DOI%3A-,10.2527/jas1979.493729x,-No abstract available

                1 Reply Last reply Reply Quote 1
                • alfredoolivasA Offline
                  alfredoolivas @alfredoolivas
                  last edited by

                  0.13mg/kg TBA a day was more effective than 2.5mg/kg TBA in supressing TAT.

                  alfredoolivasA 1 Reply Last reply Reply Quote 1
                  • alfredoolivasA Offline
                    alfredoolivas @alfredoolivas
                    last edited by

                    "in France, the average weight for seniors tends to be around 66-67 kg"

                    For these people, 7mg a day of tren would supress TAT by 30%. This is what Parabolan would deliver shortly after the first injection

                    sunsunsunS 1 Reply Last reply Reply Quote 0
                    • sunsunsunS Offline
                      sunsunsun @alfredoolivas
                      last edited by

                      interdasting

                      1 Reply Last reply Reply Quote 1
                      • alfredoolivasA Offline
                        alfredoolivas @engineer
                        last edited by alfredoolivas

                        @engineer bodybuilders are now starting to realise how powerful it is in low doses. Vigorous Steve was the one that put me onto this a year ago. It’s 8x more anabolic than testosterone, so of course they will abuse it and inject more.

                        1 Reply Last reply Reply Quote 0
                        • alfredoolivasA Offline
                          alfredoolivas
                          last edited by alfredoolivas

                          Lowers prolactin and GH as well as insulin the most.
                          1ae745f2-bb35-47f2-aa6e-1d30b0a78d53-image.png
                          https://www.cambridge.org/core/journals/animal-science/article/abs/effect-of-trenbolone-on-acetate-growth-blood-hormones-and-metabolites-and-nitrogen-balance-of-beef-heifers/8B3677C602A7E26F05252173EBBD474C

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                          • alfredoolivasA Offline
                            alfredoolivas
                            last edited by alfredoolivas

                            4c8871c5-287b-48c8-9a06-aa54ad7e0a1f-image.png

                            It decreases faty acid synthase, ACC in liver, adipose and muscle and LIPOLYSIS IN ADIPOSE TISSUE. It increases lipolysis in the liver and muscle, but allows adipose tissue to not release FFA into the blood!
                            10.1055/s-2007-1018919

                            1 Reply Last reply Reply Quote 0
                            • alfredoolivasA Offline
                              alfredoolivas
                              last edited by

                              Seems to make turkeys with weak legs more excitable, indicating it increases intracellular calcium
                              cfec36a0-9054-4353-aac0-d92faa12e3bc-image.png

                              10.1080/00071688108447879

                              alfredoolivasA 1 Reply Last reply Reply Quote 0
                              • alfredoolivasA Offline
                                alfredoolivas @alfredoolivas
                                last edited by

                                " the anabolic action of TP and TBA, especially in female rats, may be mediated through an antagonistic effect to the catabolic effects of oestrogens and glucocorticoids."
                                https://www.semanticscholar.org/paper/Effect-of-sex%2C-testosterone-propionate-and-acetate-Santidrián-Thompson/64ece3bf3a3cd424d83611cfad2d54f94912c41c

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                                • alfredoolivasA Offline
                                  alfredoolivas
                                  last edited by alfredoolivas

                                  decreases FFA " Plasma triglyceride concentrations in all
                                  implanted groups fell markedly by week 5 and remained well
                                  below control values until slaughter. The concentration of
                                  plasma non-esterified fatty acids decreased by approximately
                                  50% in all four treatment groups
                                  "

                                  b6eb3ab6-0ebb-40ad-b7a7-ed03abace780-image.png

                                  f4366e4a-b08a-4a61-95b5-1ff3cedf07b4-image.png

                                  Low doses of tren & E2 had lower cholesterol.

                                  https://pubmed.ncbi.nlm.nih.gov/7152469/

                                  1 Reply Last reply Reply Quote 0
                                  • alfredoolivasA Offline
                                    alfredoolivas
                                    last edited by

                                    "TB A also had no effect on either the digestibility or metabolizability of the energy in the diet, or on the total energy retained by the two experimental groups...there were significant differences in the way this energy was partitioned for growth between treated and control animals. "

                                    It doesn't cause fat loss via increasing metabolism?

                                    https://www.researchgate.net/publication/231925431_The_effect_of_trenbolone_acetate_on_growth_rate_and_carcass_composition_of_young_female_rabbits

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                                    • alfredoolivasA Offline
                                      alfredoolivas
                                      last edited by

                                      " Trenbolone, however, did not demonstrate any genotoxic effect in the assays performed."
                                      https://pubmed.ncbi.nlm.nih.gov/3090982/

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                                      • alfredoolivasA Offline
                                        alfredoolivas
                                        last edited by alfredoolivas

                                        a2097a76-0e88-4866-88ac-9d05c7ba9277-image.png
                                        Decreases fat cell size

                                        adef3e8f-aea9-457c-9d38-217b5e58d4a8-image.png
                                        Decreases FAS and increases G6PD and other genes involved with NADPH formation

                                        https://pubmed.ncbi.nlm.nih.gov/3583947/

                                        200mg TBA implant given once every 56 days with a 60 day withdrawal period.

                                        I am not going to even estimate the amount of tren built up and released lol

                                        But that is 3.57mg TBA (2.85mg elemental weight) every day given to Heifers, with a 60 day withdrawal period.
                                        9dd8310f-fc83-4fff-94fd-8a5140cc2e82-image.png

                                        French were giving 5mg a day to 65kg humans XDXD.
                                        Bro if 2.85mg of trenbolone can do this to a HEIFER after 60 days of no tren then imagine what 5mg does to a human @engineer

                                        alfredoolivasA 1 Reply Last reply Reply Quote 0
                                        • alfredoolivasA Offline
                                          alfredoolivas @alfredoolivas
                                          last edited by

                                          I think tren only cycles may be good, because OVX with tren was often more effective than tren by itself.

                                          Lowering endogenous sex steroids like progesterone, estradiol and test WITH tren can be even more anti-lipolitc.

                                          bee75c2e-c1dc-4265-a5b3-6727cd26da85-image.png

                                          alfredoolivasA 1 Reply Last reply Reply Quote 0
                                          • alfredoolivasA Offline
                                            alfredoolivas @alfredoolivas
                                            last edited by

                                            @sunsunsun my inuition may be correct😉 😉

                                            @sunsunsun said in moggy chicken log:

                                            @alfredoolivas but why u think androstane avoidance is le good

                                            @alfredoolivas said in moggy chicken log:

                                            @sunsunsun intuition😉

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