The anti-cortisol mechanism of trenbolone
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Trenboloen decreases aromatase:
" The results indicated that 17β-trenbolone exposure decreased the number of primordial germ cells at 1 dpf and 3 dpf, decreased expression of ovarian differentiation-related genes foxl2 and cyp19a1a at 60 dpf, increased expression of testis differentiation-related genes dmrt1"
"Cyp19a1a (cytochrome P450, family 19, subfamily A, polypeptide 1a) is a crucial gene in teleost fish that encodes gonadal aromatase, an enzyme responsible for converting androgens into estrogens to drive ovarian development."
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@alfredoolivas are you using LDT right now to achieve moggy chicken?
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Decreases metabolic rate. This could be becayse they were eating less. T3 dropped by 0.3. So it doesn't cause fat loss by increasing metabolism. Mifeprestone also doesn't increase the metabolic rate and causes weight loss, so it could be due to supression of lipogenic pathways and less appetiete
Also found this interesting part
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"A combined implant of 17 beta-estradiol trenbolone acetate in young male goats decreased blood glucose and insulin 28 d after treatment, but had no effect on growth or thyroid hormones. No relation was found between hormonal concentrations and growth performance."
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Trenbolone greatly decreases corticosterone and ACTH, whreas testosterone increases it!!!
https://pubmed.ncbi.nlm.nih.gov/2170557/]]0.1296mg/kg HED.
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"Interestingly, potent anabolic steroid trenbolone bound to the glucocorticoid receptor with an affinity almost as high as that of corticosterone, the endogenous glucocorticoid in the rat " not cortisol ik
10.1016/0022-4731(86)90109-3 -
https://avmajournals.avma.org/view/journals/ajvr/52/2/ajvr.1991.52.02.282.xml?tab_body=pdf
Trenbolone derivative, via being a progestin, can treat endotoxinemia
"Evaluation of progesterone deficiency as a cause of fetal death in mares with experimentally induced endotoxemia"
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decreased cholesterol and FFA
10.2527/1993.71102659x -
It seems to decrease cholesterol, prolactin, increase heart rate slightly and temps remain neutral.
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Decreases desaturase enzymes (estradiol was added to too). Other studies show it increases SFA to MUFA ratio
10.2527/jas.2006-280 -
decreases beta 1, beta 3 adrenaline receptors but increase beta 2
10.1111/j.1439-0396.2007.00675.x
I hypothesise that it is adrenergic but anti cortisol, because of the study that suggested it was excitable and calcium handling may be altered
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It decreases brain aromatase
It increases ERb, but so does the aromatase inhibitor fedarazole
10.1897/08-082.1
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Increases gonad size
10.1016/j.marenvres.2009.09.009 -
"co-treatment with 17-TBOH and flutamide (an AR antagonist) also results in anti-estrogenic activity in female fathead minnows"
"17-TBOH, alone or in combination with 17- E2, has been shown to increase the cross-sectional area (CSA) of type I, but not type II, skeletal muscle fibers and induce a fiber switch from more glycolytic to more oxidative fibers, J.F. Yarrow et al. / Steroids 75 (2010) 377–389 381 indicating an increase in the oxidative capacity of skeletal muscle [152,189]. "
"As a result of its anti-glucocorticoid actions, 17-TBOH produces a more robust inhibition of protein degradation than does testosterone, which only slightly reduces protein degradation while increasing protein synthesis "
"Preliminary evidence from our laboratory indicates that the enanthate ester of 17-TBOH protects against hypogonadism induced cancellous bone loss to the same extent as supraphysiological testosterone
"In our hands, the lipolytic effects of 17-TBOH-enanthate are even more potent than that of supraphysiological testosterone-enanthate (unpublished laboratory results)"
10.1016/j.steroids.2010.01.019
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Trenbolone is a Carbonic Anhydrase Inhibitor
10.3109/14756366.2011.584535
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Decreases desaturase enzymes
10.2527/jas.2011-3496 -
Trenbolone derivative is anti estrogenic
The use of altrenogest to avoid hyperestrogenism after eCG-hCG ovulation induction in southern tigrina (Leopardus guttulus) -
I suspected the membrane receptors such as the membrane estrogen receptors to be the cause of trenboloens side effects, might be true
https://pubmed.ncbi.nlm.nih.gov/26440329/
https://pubmed.ncbi.nlm.nih.gov/27285910/ -
Tren decreases estrogen receptors A and B & aromatase in the brain
https://pubmed.ncbi.nlm.nih.gov/26098908/ -
"To address this, we exposed wild male guppies (Poecilia reticulata) to an environmentally realistic concentration of 17β-trenbolone (average measured concentration: 8 ng/L) for 21 days using a flow-through system. We found that, in the presence of a competitor, 17β-trenbolone-exposed males carried out more frequent aggressive behaviours towards rival males than did unexposed males, as well as performing less courting behaviour and more sneak (i.e., coercive) mating attempts towards female"
https://pubmed.ncbi.nlm.nih.gov/28854383/
Basically nanogram doses of tren turned "guppies"? into rapists with no intent for marriage
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