Essential Fatty Acids (Omega-3 & Omega-6) are direct building blocks for the skin's lipid bilayers, reducing transepidermal water loss (TEWL).
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@AlphaZance hi, any picture available of a human hand skin from a person that was label as essential fatty acid deficient in one of these experiments?
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Human essential fatty acid deficiency: treatment by topical application of linoleic acid
Abstract
An essential fatty acid (EFA) deficiency developed in a 19-year-old man who was being maintained on a long-term regimen of fat-free, intravenous hyperalimentation fluids. The EFA deficiency was reversed after 21 days by daily, topical application of linoleic acid to the patient's skin. The ratio of eicosatrienoic acid (20:3, n-9) to eicosatetraenoic acid (20:4, n-6) decreased to normal levels in the skin and serum with clinical improvement of the EFA deficiency syndrome. The cutaneous manifestations (scalp dermatitis, alopecia, and depigmentation of hair) were reversed with continued, topical application of safflower oil, which contains 60% to 70% linoleic acid.
https://pubmed.ncbi.nlm.nih.gov/406855/Essential fatty acid deficiency while a patient receiving fat regimen total parenteral nutrition
Abstract
A 32-year-old man was diagnosed with lymphoma and underwent Billroth’s II operation because of upper gastrointestinal haemorrhage. Although the patient received fat regimen total parenteral nutrition (TPN), the patient developed typical skin rash of essential fatty acid deficiency after 2 weeks of starting TPN. The diagnosis was confirmed by biochemical and histological analyses. After increasing the lipid infusion, the rash was gradually improved with complete resolution after 19 days.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3387468/ -
@AlphaZance i can not open the full text links, could you share the picture of the first link on the thread?
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