Aspirin allergy?

jens

Does anyone here have experience with curing an allergy to acetylsalicylic and salicylic acids? many of my relatives have developed an allergy to aspirin in their twenties, making me think that the allergy is caused from an accumulation of stress. Does anyone know the underlying cause of this allergy?

yerrag

@jens

I don't remember the source, but have read that guts that are sensitive to aspirin are due to having a deficiency in copper. It doesn't go much deeper than that, but my guess is that it may involve an enzyme that needs copper.

jens

@yerrag I will find a relative to guinea pig and have them eat liver and oysters frequently to see if it reverses aspirin allergy. Interestingly, even just a few milligrams of aspirin applied anywhere on the skin is enough to induce a large enough systemic reaction that an antihistamine is needed.

yerrag

@jens

If it's copper in food, I have been successful eating a relative of shrimp (based on Peat saying shrimp is copper rich) on a regular basis, and after a year my ceruloplasmin , a copper enzyme, went up from low to high of reference range.

I had to find an alternative to shrimp as it's next to impossible to find shrimp that isn't farm raised with antibiotics and feeds. A small crustacean that is widely uses as a seasoning paste in Southeast Asia was what I ate. The paste is called bagoong and I sautee it with a green leaf veggie called kangkong (convolvus). The paste is made from fermented 'alamang.' It can be found in Filipino grocery stores but in Asian grocery stores it is called by other names.

Supplementing with copper is hit or miss as no one really knows the right dosage, so it's better to eat food rich in copper.

cedric

@jens /all
It could be low glycine, upregulated histamine, low copper/DAO, HNMT/methylation deficiency.
https://www.histaminintoleranz.ch/en/therapy_medicaments.html
https://mthfrsupport.com.au/2016/09/dao-deficiency-and-histamine-the-unlikely-connection/
https://www.deficitdao.org/en/dao-deficiency/origin-of-dao-deficiency/pharmacological-factors/
After supplementing glycine,increasing DAO/methylation/HNMT bee venom therapy (for example in cream could bring histamine back down).
Benzoate/salicylate lower glycine

https://en.wikipedia.org/wiki/Glycine
" Glycine is extremely sensitive to antibiotics which target folate, and blood glycine levels drop severely within a minute of antibiotic injections. Some antibiotics can deplete more than 90% of glycine within a few minutes of being administered.[30]"
https://en.wikipedia.org/wiki/Hippuric_acid
" Hippuric acid (Gr. hippos, horse, ouron, urine) is a carboxylic acid and organic compound. It is found in urine and is formed from the combination of benzoic acid and glycine. Levels of hippuric acid rise with the consumption of phenolic compounds (such as fruit juice, tea and wine). The phenols are first converted to benzoic acid, and then to hippuric acid and excreted in urine.[1]
Hippuric acid crystallizes in rhombic prisms which are readily soluble in hot water, melt at 187 °C, and decompose at about 240 °C. High concentrations of hippuric acid may also indicate a toluene intoxication; however, scientists have called this correlation into question because there are other variables that affect levels of hippuric acid.[2] When many aromatic compounds such as benzoic acid and toluene are taken internally, they are converted to hippuric acid by reaction with the amino acid, glycine.

Synthesis
[...]
Hippuric acid has been reported to be a marker for Parkinson's disease.[7]

BioEclectic

@cedric
Excellent info as usual Cedric, much of which is new to me. Am filing this under Aspirin, Glycine, etc etc.

CO3

@jens probably a simple misintepretation of the facts!