Fixing poor motor coordination?
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@mostlylurking said in Fixing poor motor coordination?:
Here's an article that you may find of interest:
Niacin, Riboflavin, and ThiaminThanks. I finished reading it just now.
It gave me a better idea of how niacin differs from niacinamide.
Also, it made me realize how thiamine can be exhausted when it is used more to compensate for the inability to produce NAD from tryptophan because of deficiency in one of these 3 substances - riboflavin (b2), pyridoxine (b6), and vitamin C - in the kynerunine pathway. and when there is also a deficiency in niacinamide, which is needed in the other pathway to make NAD.
As I had been taking a blend of thiamine hcl, niacinamide, pyridoxine, and riboflavin - 1000mg/500mg/30mg/50 mg twice daily the past 2 weeks, I noticed that my ataxia and vertigo has become less noticeable when I added ascorbic acid intake of 2 x 500 mg daily. This, I believe, says something about enabling the body to make its own niacin from tryptophan. It may also mean that the tryptophan being diverted to produce niacin is helping lessen its production of serotonin and estrogen.
However, I'm still suffering from a milder form of ataxia in terms of being clumsy. I had been having things fall from my grip, and just today I broke another glass, the t in 2 years, when I would not break one in ten years or more. Just goes to show being clumsy and prone to accidental breakage is a mild symptoms related to neurological issues that may be helped by more intake of b-vitamins.
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@yerrag said in Fixing poor motor coordination?:
@mostlylurking said in Fixing poor motor coordination?:
Here's an article that you may find of interest:
Niacin, Riboflavin, and ThiaminThanks. I finished reading it just now.
It gave me a better idea of how niacin differs from niacinamide.
Also, it made me realize how thiamine can be exhausted when it is used more to compensate for the inability to produce NAD from tryptophan because of deficiency in one of these 3 substances - riboflavin (b2), pyridoxine (b6), and vitamin C - in the kynerunine pathway. and when there is also a deficiency in niacinamide, which is needed in the other pathway to make NAD.
As I had been taking a blend of thiamine hcl, niacinamide, pyridoxine, and riboflavin - 1000mg/500mg/30mg/50 mg twice daily the past 2 weeks, I noticed that my ataxia and vertigo has become less noticeable when I added ascorbic acid intake of 2 x 500 mg daily. This, I believe, says something about enabling the body to make its own niacin from tryptophan. It may also mean that the tryptophan being diverted to produce niacin is helping lessen its production of serotonin and estrogen.
Good insights. My own dosages differ a little from yours; I take: 1000mg thiamine hcl 2Xday, also 100mg niacinamide, 100mg riboflavin 4Xday, about 10-20mg b6 1Xday.
I remember that I was very clumsy in the past, better now. There were times when I'd be just standing there (not moving around at all) and I'd just fall down/collapse.
However, I'm still suffering from a milder form of ataxia in terms of being clumsy. I had been having things fall from my grip, and just today I broke another glass, the t in 2 years, when I would not break one in ten years or more. Just goes to show being clumsy and prone to accidental breakage is a mild symptoms related to neurological issues that may be helped by more intake of b-vitamins.
It is my understanding that improvements from taking high dose thiamine hcl continue to happen for 6 months. Dr. Costantini said that, I believe. It takes a while for the workarounds that the body set up to keep from dying to unwind (per Dr. Chandler Marrs).
You might find the information found in Costantini's FAQs of interest.
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@mostlylurking said in Fixing poor motor coordination?:
@yerrag said in Fixing poor motor coordination?:
@mostlylurking said in Fixing poor motor coordination?:
Here's an article that you may find of interest:
Niacin, Riboflavin, and ThiaminThanks. I finished reading it just now.
It gave me a better idea of how niacin differs from niacinamide.
Also, it made me realize how thiamine can be exhausted when it is used more to compensate for the inability to produce NAD from tryptophan because of deficiency in one of these 3 substances - riboflavin (b2), pyridoxine (b6), and vitamin C - in the kynerunine pathway. and when there is also a deficiency in niacinamide, which is needed in the other pathway to make NAD.
As I had been taking a blend of thiamine hcl, niacinamide, pyridoxine, and riboflavin - 1000mg/500mg/30mg/50 mg twice daily the past 2 weeks, I noticed that my ataxia and vertigo has become less noticeable when I added ascorbic acid intake of 2 x 500 mg daily. This, I believe, says something about enabling the body to make its own niacin from tryptophan. It may also mean that the tryptophan being diverted to produce niacin is helping lessen its production of serotonin and estrogen.
Good insights. My own dosages differ a little from yours; I take: 1000mg thiamine hcl 2Xday, also 100mg niacinamide, 100mg riboflavin 4Xday, about 10-20mg b6 1Xday.
I seem to do okay with having a higher dosage of niacinamide than yours. But I had begun adding niacin, with just 2x30mg a day. Good thing I am extra cautious, as with that dosage I began to experience itching, and they were centered on my recent wounds (cat bite and claw marks) and my keloids.
I have also seen that on my nightly spO2 charts, my spO2 has not been dropping a lot as before, even as I held on on taking antibacterials. I wanted to know if these b-vitamins are helping me fight off the low-grade infections that I associate with the spO2 drops. I would have to see what that really means over the coming weeks as I observe the effects on me. It's a longer piece to explain, but I will save it for later as I can be rambling if I make conclusions prematurely.I remember that I was very clumsy in the past, better now. There were times when I'd be just standing there (not moving around at all) and I'd just fall down/collapse.
Glad you improved from there. I seem to be more coordinated and balanced adding the small bit of niacin into my protocol. But it could just be in my head. Long term, I want to find stronger confirmation.
However, I'm still suffering from a milder form of ataxia in terms of being clumsy. I had been having things fall from my grip, and just today I broke another glass, the t in 2 years, when I would not break one in ten years or more. Just goes to show being clumsy and prone to accidental breakage is a mild symptoms related to neurological issues that may be helped by more intake of b-vitamins.
It is my understanding that improvements from taking high dose thiamine hcl continue to happen for 6 months. Dr. Costantini said that, I believe. It takes a while for the workarounds that the body set up to keep from dying to unwind (per Dr. Chandler Marrs).
You might find the information found in Costantini's FAQs of interest.
Thanks. I'll give it a look.
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This post is deleted! -
@yerrag said in Fixing poor motor coordination?:
@mostlylurking said in Fixing poor motor coordination?:
@yerrag said in Fixing poor motor coordination?:
@mostlylurking said in Fixing poor motor coordination?:
Here's an article that you may find of interest:
Niacin, Riboflavin, and ThiaminThanks. I finished reading it just now.
It gave me a better idea of how niacin differs from niacinamide.
Also, it made me realize how thiamine can be exhausted when it is used more to compensate for the inability to produce NAD from tryptophan because of deficiency in one of these 3 substances - riboflavin (b2), pyridoxine (b6), and vitamin C - in the kynerunine pathway. and when there is also a deficiency in niacinamide, which is needed in the other pathway to make NAD.
As I had been taking a blend of thiamine hcl, niacinamide, pyridoxine, and riboflavin - 1000mg/500mg/30mg/50 mg twice daily the past 2 weeks, I noticed that my ataxia and vertigo has become less noticeable when I added ascorbic acid intake of 2 x 500 mg daily. This, I believe, says something about enabling the body to make its own niacin from tryptophan. It may also mean that the tryptophan being diverted to produce niacin is helping lessen its production of serotonin and estrogen.
Good insights. My own dosages differ a little from yours; I take: 1000mg thiamine hcl 2Xday, also 100mg niacinamide, 100mg riboflavin 4Xday, about 10-20mg b6 1Xday.
I seem to do okay with having a higher dosage of niacinamide than yours. But I had begun adding niacin, with just 2x30mg a day. Good thing I am extra cautious, as with that dosage I began to experience itching, and they were centered on my recent wounds (cat bite and claw marks) and my keloids.
Do you know if the cat injuries added to your health issues long term? Cat bites/deep claw injuries can be pretty bad. My brother was scratched when he was a child and got "cat scratch fever" from it, complete with swollen lymph nodes. I think the doctor cut the wound open to clean it; I remember he had about 4-5 stitches at the scratch site.
Maybe the itching shows that there's still something going on at the injury site? My husband and I have been using horse Ivermectin for skin problems; it seems to help. Ivermectin is a fungicide, antibiotic, antiviral, etc. Just a thought.... Could be the source for a continuing infection? Have you considered taking an oral round of Ivermectin for people? I don't know where you are. I'm in the U.S. so I went to Indiamart online and searched for USP grade Ivermectin and found a supplier in about 30 seconds. onlinereliefpharmacy.com, Iverheal is the name of the product. You would need to research the dosage needed; I rely on https://covid19criticalcare.com/protocol/i-prevent-covid-flu-rsv/ for dosage info. This might not even be pertinent, but then again, it might help.
I have also seen that on my nightly spO2 charts, my spO2 has not been dropping a lot as before, even as I held on on taking antibacterials. I wanted to know if these b-vitamins are helping me fight off the low-grade infections that I associate with the spO2 drops. I would have to see what that really means over the coming weeks as I observe the effects on me. It's a longer piece to explain, but I will save it for later as I can be rambling if I make conclusions prematurely.
I remember that I was very clumsy in the past, better now. There were times when I'd be just standing there (not moving around at all) and I'd just fall down/collapse.
Glad you improved from there. I seem to be more coordinated and balanced adding the small bit of niacin into my protocol. But it could just be in my head. Long term, I want to find stronger confirmation.
Perhaps you could research what else might improve your immune system. Maybe you already have. I've read that thiamine is needed to make nitric oxide which is used by the immune system. If you have high oxidative stress, thiamine counteracts it and also gets used up by it. I think that my own issue with mercury poisoning causes high oxidative stress which causes me to need the high dose thiamine to counteract that stress.
However, I'm still suffering from a milder form of ataxia in terms of being clumsy. I had been having things fall from my grip, and just today I broke another glass, the t in 2 years, when I would not break one in ten years or more. Just goes to show being clumsy and prone to accidental breakage is a mild symptoms related to neurological issues that may be helped by more intake of b-vitamins.
It is my understanding that improvements from taking high dose thiamine hcl continue to happen for 6 months. Dr. Costantini said that, I believe. It takes a while for the workarounds that the body set up to keep from dying to unwind (per Dr. Chandler Marrs).
You might find the information found in Costantini's FAQs of interest.
Thanks. I'll give it a look.
you're welcome
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@mostlylurking said in Fixing poor motor coordination?:
@yerrag said in Fixing poor motor coordination?:
@mostlylurking said in Fixing poor motor coordination?:
@yerrag said in Fixing poor motor coordination?:
@mostlylurking said in Fixing poor motor coordination?:
Here's an article that you may find of interest:
Niacin, Riboflavin, and ThiaminThanks. I finished reading it just now.
It gave me a better idea of how niacin differs from niacinamide.
Also, it made me realize how thiamine can be exhausted when it is used more to compensate for the inability to produce NAD from tryptophan because of deficiency in one of these 3 substances - riboflavin (b2), pyridoxine (b6), and vitamin C - in the kynerunine pathway. and when there is also a deficiency in niacinamide, which is needed in the other pathway to make NAD.
As I had been taking a blend of thiamine hcl, niacinamide, pyridoxine, and riboflavin - 1000mg/500mg/30mg/50 mg twice daily the past 2 weeks, I noticed that my ataxia and vertigo has become less noticeable when I added ascorbic acid intake of 2 x 500 mg daily. This, I believe, says something about enabling the body to make its own niacin from tryptophan. It may also mean that the tryptophan being diverted to produce niacin is helping lessen its production of serotonin and estrogen.
Good insights. My own dosages differ a little from yours; I take: 1000mg thiamine hcl 2Xday, also 100mg niacinamide, 100mg riboflavin 4Xday, about 10-20mg b6 1Xday.
I seem to do okay with having a higher dosage of niacinamide than yours. But I had begun adding niacin, with just 2x30mg a day. Good thing I am extra cautious, as with that dosage I began to experience itching, and they were centered on my recent wounds (cat bite and claw marks) and my keloids.
Do you know if the cat injuries added to your health issues long term? Cat bites/deep claw injuries can be pretty bad. My brother was scratched when he was a child and got "cat scratch fever" from it, complete with swollen lymph nodes. I think the doctor cut the wound open to clean it; I remember he had about 4-5 stitches at the scratch site.
Thanks for the concern, but cat scratches and bites are nothing new to me. I use urea on them and the effects are neutralized. I also use urea on my cats when they get injured on cat fights and they heal quickly as well.
The reason I mention the cat scratches and bites is that for a long time I have not experienced the itchiness of healing from being wounded. I remember as a child that when my wound heals I experience itchiness and then I would learn to see the itchiness as a good thing. But now the itchiness resuming can only be seen by me as a good sign. Perhaps the intake of niacin is giving that itchiness back.
Maybe the itching shows that there's still something going on at the injury site? My husband and I have been using horse Ivermectin for skin problems; it seems to help. Ivermectin is a fungicide, antibiotic, antiviral, etc. Just a thought.... Could be the source for a continuing infection? Have you considered taking an oral round of Ivermectin for people? I don't know where you are. I'm in the U.S. so I went to Indiamart online and searched for USP grade Ivermectin and found a supplier in about 30 seconds. onlinereliefpharmacy.com, Iverheal is the name of the product. You would need to research the dosage needed; I rely on https://covid19criticalcare.com/protocol/i-prevent-covid-flu-rsv/ for dosage info. This might not even be pertinent, but then again, it might help.
I have also seen that on my nightly spO2 charts, my spO2 has not been dropping a lot as before, even as I held on on taking antibacterials. I wanted to know if these b-vitamins are helping me fight off the low-grade infections that I associate with the spO2 drops. I would have to see what that really means over the coming weeks as I observe the effects on me. It's a longer piece to explain, but I will save it for later as I can be rambling if I make conclusions prematurely.
I remember that I was very clumsy in the past, better now. There were times when I'd be just standing there (not moving around at all) and I'd just fall down/collapse.
Glad you improved from there. I seem to be more coordinated and balanced adding the small bit of niacin into my protocol. But it could just be in my head. Long term, I want to find stronger confirmation.
Perhaps you could research what else might improve your immune system. Maybe you already have. I've read that thiamine is needed to make nitric oxide which is used by the immune system. If you have high oxidative stress, thiamine counteracts it and also gets used up by it. I think that my own issue with mercury poisoning causes high oxidative stress which causes me to need the high dose thiamine to counteract that stress.
I think that thiamine and the other b-vitamins help my immune system. Not that many other factors don't. But this is a side I have not given much emphasis. It could be simply that the NADPH of the pentose phosphate pathway that uses thiamine a lot to produce NADPH needed to produce superoxide as enabling the production of ROS enables the immune system to fight off infections more effectively. And the other b- vitamins may be needed as well to produce anti-bacterial proteins that are used intracellularly. Altogether, the body's immune can be potentiated.
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@yerrag OK; so you are interpreting the itchiness as a good thing like the healing is resuming/completing?
When I was hypothyroid and being inadequately treated by the doctor, I was unable to heal small injuries on my forearms that I got pruning my roses. These same little wounds were unable to heal for something like two years. Then I switched doctors, got some Armour Thyroid desiccated thyroid, and the wounds healed quickly.
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@mostlylurking Yes. The itching I experience though, only happens at night. In the wee hours to be more specific. I think it is around the time when the liver is active in doing its maintenance, as it is one of those times when my spO2 can suffer a huge drop, reflecting liver activity as far as fighting internal infections go, which uses a lot of phagocytic activity involving ROS which engulfs and kills pathogens. The itchiness I would guess is indicative of inflammatory activity which allows neutrophils and other white blood cells to enter tissues to enable phagocytic activity on the deeper tissues which are less accessible to white blood cells normally. The phagocytes use a lot of oxygen in the respiratory burst of phagocytosis, which I think is what causes my spO2 to drop sporadically during the liver hours (according to TCM) between 1 and 3 pm.
The histaminic action causes the itchiness, and maybe causes me to wake up during the liver hours.
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@yerrag said in Fixing poor motor coordination?:
@mostlylurking Yes. The itching I experience though, only happens at night. In the wee hours to be more specific. I think it is around the time when the liver is active in doing its maintenance, as it is one of those times when my spO2 can suffer a huge drop, reflecting liver activity as far as fighting internal infections go, which uses a lot of phagocytic activity involving ROS which engulfs and kills pathogens. The itchiness I would guess is indicative of inflammatory activity which allows neutrophils and other white blood cells to enter tissues to enable phagocytic activity on the deeper tissues which are less accessible to white blood cells normally. The phagocytes use a lot of oxygen in the respiratory burst of phagocytosis, which I think is what causes my spO2 to drop sporadically during the liver hours (according to TCM) between 1 and 3 pm.
The histaminic action causes the itchiness, and maybe causes me to wake up during the liver hours.
Very interesting.... So it seems you have a systemic infection caused by... does it really matter at this point?
Have you looked into chlorine dioxide? It's an interesting topic. Lots of research first before you play around with it is a good idea. Slow and conservative is better than overdoing it as taking too much too fast can make you feel pretty bad and doesn't work as well as sipping it over a period of 5-7 hours.
Here's a video for your consideration: https://odysee.com/@Happy:9/ChlorineDioxide:0
Andreas Kalcker's videos are very good. Here is one: https://odysee.com/@TranquilloPapi:b/What-is-CDS:e There are more available in Spanish than in English I think.
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@yerrag said in Fixing poor motor coordination?:
@mostlylurking said in Fixing poor motor coordination?:
@yerrag said in Fixing poor motor coordination?:
@mostlylurking said in Fixing poor motor coordination?:
@yerrag said in Fixing poor motor coordination?:
@mostlylurking said in Fixing poor motor coordination?:
Here's an article that you may find of interest:
Niacin, Riboflavin, and ThiaminThanks. I finished reading it just now.
It gave me a better idea of how niacin differs from niacinamide.
Also, it made me realize how thiamine can be exhausted when it is used more to compensate for the inability to produce NAD from tryptophan because of deficiency in one of these 3 substances - riboflavin (b2), pyridoxine (b6), and vitamin C - in the kynerunine pathway. and when there is also a deficiency in niacinamide, which is needed in the other pathway to make NAD.
As I had been taking a blend of thiamine hcl, niacinamide, pyridoxine, and riboflavin - 1000mg/500mg/30mg/50 mg twice daily the past 2 weeks, I noticed that my ataxia and vertigo has become less noticeable when I added ascorbic acid intake of 2 x 500 mg daily. This, I believe, says something about enabling the body to make its own niacin from tryptophan. It may also mean that the tryptophan being diverted to produce niacin is helping lessen its production of serotonin and estrogen.
Good insights. My own dosages differ a little from yours; I take: 1000mg thiamine hcl 2Xday, also 100mg niacinamide, 100mg riboflavin 4Xday, about 10-20mg b6 1Xday.
I seem to do okay with having a higher dosage of niacinamide than yours. But I had begun adding niacin, with just 2x30mg a day. Good thing I am extra cautious, as with that dosage I began to experience itching, and they were centered on my recent wounds (cat bite and claw marks) and my keloids.
Do you know if the cat injuries added to your health issues long term? Cat bites/deep claw injuries can be pretty bad. My brother was scratched when he was a child and got "cat scratch fever" from it, complete with swollen lymph nodes. I think the doctor cut the wound open to clean it; I remember he had about 4-5 stitches at the scratch site.
Thanks for the concern, but cat scratches and bites are nothing new to me. I use urea on them and the effects are neutralized. I also use urea on my cats when they get injured on cat fights and they heal quickly as well.
The reason I mention the cat scratches and bites is that for a long time I have not experienced the itchiness of healing from being wounded. I remember as a child that when my wound heals I experience itchiness and then I would learn to see the itchiness as a good thing. But now the itchiness resuming can only be seen by me as a good sign. Perhaps the intake of niacin is giving that itchiness back.
Maybe the itching shows that there's still something going on at the injury site? My husband and I have been using horse Ivermectin for skin problems; it seems to help. Ivermectin is a fungicide, antibiotic, antiviral, etc. Just a thought.... Could be the source for a continuing infection? Have you considered taking an oral round of Ivermectin for people? I don't know where you are. I'm in the U.S. so I went to Indiamart online and searched for USP grade Ivermectin and found a supplier in about 30 seconds. onlinereliefpharmacy.com, Iverheal is the name of the product. You would need to research the dosage needed; I rely on https://covid19criticalcare.com/protocol/i-prevent-covid-flu-rsv/ for dosage info. This might not even be pertinent, but then again, it might help.
I have also seen that on my nightly spO2 charts, my spO2 has not been dropping a lot as before, even as I held on on taking antibacterials. I wanted to know if these b-vitamins are helping me fight off the low-grade infections that I associate with the spO2 drops. I would have to see what that really means over the coming weeks as I observe the effects on me. It's a longer piece to explain, but I will save it for later as I can be rambling if I make conclusions prematurely.
I remember that I was very clumsy in the past, better now. There were times when I'd be just standing there (not moving around at all) and I'd just fall down/collapse.
Glad you improved from there. I seem to be more coordinated and balanced adding the small bit of niacin into my protocol. But it could just be in my head. Long term, I want to find stronger confirmation.
Perhaps you could research what else might improve your immune system. Maybe you already have. I've read that thiamine is needed to make nitric oxide which is used by the immune system. If you have high oxidative stress, thiamine counteracts it and also gets used up by it. I think that my own issue with mercury poisoning causes high oxidative stress which causes me to need the high dose thiamine to counteract that stress.
I think that thiamine and the other b-vitamins help my immune system. Not that many other factors don't. But this is a side I have not given much emphasis. It could be simply that the NADPH of the pentose phosphate pathway that uses thiamine a lot to produce NADPH needed to produce superoxide as enabling the production of ROS enables the immune system to fight off infections more effectively. And the other b- vitamins may be needed as well to produce anti-bacterial proteins that are used intracellularly. Altogether, the body's immune can be potentiated.
You might maybe find this short article of interest. download the pdf available at the link: RIBOFLAVIN, A TESTOSTERONE 5α-REDUCTASE INHIBITOR
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@mostlylurking
Ooohhh!
