Cyproheptadine Warning
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Been using Cypro quite a bit the past few days and have been feeling pretty lazy and lethargic which I mostly expected. Today however, I decided to smoke a cigarette. Afterwards I felt quite off and experienced a large increase in heart rate. Currently at about 130 BPM. I'm not too concerned right now as it has fallen a little. And I expect it to fall more shortly. If not, I'll seek medical attention. Just figured I'd throw the warning out there for any Cypro users.
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@Master How much are you taking? Too much can start driving serotonin and prolactin up.
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@tea I took quite a bit yesterday, I think around 12-15mgs. But today I'm taking a break.
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@Master said in Cyproheptadine Warning:
around 12-15mgs
Wow! The standard protocol is starting with .5 to 1 mg to see how it goes, and building up to 3 or 4mg max (only if needed i.e. lower doses don't provide desired effects).
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It's likely a combination of things. For one, nicotine is a stimulant. But serotonin antagonists also cause vasodilation which could result in increased heart rate, usually accompanied by lower BP (although smoking might mitigate BP reduction). Finally cyrpoheptadine is also lowering dopamine. I think there's some interplay between dopamine and heart rate as well. As it's not uncommon to witness lower heart rate with D2 agonists...likely through that feedback of lowering cyclic adenosine. Antagonizing D2 might do the opposite (just a guess really).
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@Mulloch94 Hmm this is super interesting. Appreciate the input! I unfortunately hadn't measured my heart rate prior as I didn't think to. But the nicotine sent, what was probably an already elevated heart rate, into over drive, which is how I noticed. I think a big part is that my cortisol and adrenals were basically totally shut down and cortisol/adrenaline is how your body gets nicotine's uncoupling effect under control. So without that, the uncoupling went wild. And I definitely felt it. Heart rate aside, I had a huge hot flash, sweating, lots of energy when I'd otherwise been feeling super lethargic.
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@Kvirion Guess I learned my lesson lmao.
