High-dose thiamine troubleshooting

[amizon]

@LucH

Thank you for the interest! Actually for a long time I wouldn't have called my gut sensitive--just constipated. Slow slow bowels my whole life. I have also had ENERGY problems my whole life so they are probably related one way or another. About 5-6 years ago though I started having gastritis, supposedly caused by h.pylori, and things have been much funkier and more sensitive since then in the gut department. Antibiotics for the h.pylori eradicated the bacteria but didn't solve the gastritis--however a low fodmap diet did and I've been eating low fodmap since 2020 as a result. My gut is very sensitive to anything fermentable and/or fibrous. If I eat more than incidental amounts or frequency of FODMAPs I get gastric pain and fibromyalgia symptoms. If I follow my restricted diet my symptom set is more chronic fatigue, very little pain. The only thing that helps the constipation though is miralax. All of this low energy and constipation is one of the main things that had me interested in the high-dose thiamine therapy.

I am a fan of collagen powder although lately I'm developing a bit of an aversion to it for some reason and having trouble taking it as consistently. I do take either magnesium glycinate or citrate regularly. I have tried glutamine before but it had an overstimulating, irritable effect on me unfortunately. I think I likely have dysbiosis in the form of SIBO given the fodmap intolerance but unfortunately have had trouble finding a competent doctor in my area to help treat it. I like theanine at bedtime some nights but haven't noticed any correlation with gut function, but maybe if I took it regularly instead of as-needed for sleep?

Re: thyroid, since that would be a logical next question: I'm currently taking 4 drops of Tyromix daily. It's hard to track my temps bc I often run a low-grade fever, which is common in chronic fatigue, but recently the fever has left and I've been around 98.05, so I'm interested in upping the thyroid, just trying to decide what amount to try. I was first diagnosed mildly hypothyroid in 2008 and prescribed 50mcg levothyroxine, which takes my TSH from 4.5 down to around 1.3. I've been DIY-ing mixing T3/T4 for the past couple years and don't have up to date labs atm.

[LucH]

I’m going to put some points in excerpt. I’ll develop if you are interested in.
Mind the following behavior: If you don’t agree now with one point, don’t throw away the baby with the bath-water. You may disagree but you have to say why if you want some help.
I’m not a nutritionist. I’m a teacher and I’m the administrator of a French site based on health and nutrition.
*) Former take of high dose thiamine HCL.
High dose Thiamine must be taken with some B2. Doses progressively raised. High dose thiamine has an impact on the detox pathway and histamine degradation (Cyp450 enzymatic pathway).
There is interaction between other B vitamins, especially B1 B2 B3 for glycemia. If you take B3 (niacinamide to avoid a flash reaction), you’ll need B6 + probably a methyl support (TMG) according to the type of B3. If you take B6, PLP mustn’t exceed a threshold, depending on the consumption by the body (low grade inflammation, immune reaction). Otherwise, you’ll get a problem with GABA-like symptoms (depravation) (a lack of / shortage due to a protection process of the brain: Too much of a good thing is bad).

B6 is needed / required for brain balance in the event of problems like you described. Vitamin B6 is well documented for its role as a modulator of steroid hormones: This vitamin contributes to the proper functioning of the nervous system. It participates in the synthesis of neurotransmitters, such as serotonin and dopamine, who play a crucial role in the regulation of mood, sleep and mental well-being.

But if you suffer from inflammation (low grade inflammation from bowel irritation or arthrosis if you are over 35 years old), your B6 will be burnt / exhausted.

Useful info (to read later)
-) English Corner – Vit B6: How much is too much?
https://mirzoune-ciboulette.forumactif.org/t2033-english-corner-vit-b6-how-much-is-too-much#29628
-) B6 modulates the activity of GABA. B6 as antioxidant and antipain.
https://mirzoune-ciboulette.forumactif.org/t2041-english-corner-b6-leads-to-decrease-of-cytokines-in-neuropathy#29659
-) English corner. Potential roles of Vit B6 in inflammation and immunity

[LucH]

@LucH said in High-dose thiamine troubleshooting:

-) English corner. Potential roles of Vit B6 in inflammation and immunity
https://mirzoune-ciboulette.forumactif.org/t2034-english-corner-potential-roles-of-vit-b6-in-inflammation-and-immunity#29633

[LucH]

*) Amizon says:
“I’m attempting to treat more-or-less lifelong chronic fatigue issues”
=> The thyroid acts as the carburetor of a car. Energy level.
*) Amizon says:
“Any suggestions would be much appreciated, thanks”.
=> I’ll take a Vitamin B complex 2x/w (3x at the beginning). A co-enzymed form.
*) Amizon says:
My digestion is still super out of sorts.
I wouldn't have called my gut sensitive--just constipated. Slow slow bowels my whole life.
=> Get informed on MMC. If you …
*) Amizon says:
"I started having gastritis (…) Things have been much funkier and more sensitive since then in the gut department. A low fodmap diet did [seem to] solve the problem. (…)
If I eat more than incidental amounts or frequency of FODMAPs, I get gastric pain and fibromyalgia symptoms. If I follow my restricted diet my symptom set is more chronic fatigue, very little pain. The only thing that helps the constipation though is miralax. All of this low energy and constipation is one of the main things that had me interested in the high-dose thiamine therapy."
Answer

We’ll have to work on 4 levels:

• thyroid for energy
• dysbiosis for microbiome (the microbiote is 70 – 80 % of immunity).
• MMC to get rid of stasis and the disadvantages resulting from bacterial overwhelming.
  Mind this last point (inter-digestive motility) or otherwise we won’t see the end of the tunnel. See beneath for details.

Read the following info too and come back to discuss and have a plan.
*) The English Corner: Auto immune reaction
Intolerant to foodstuff – Severe Dysfunctional Digestive System
https://mirzoune-ciboulette.forumactif.org/t2022-the-english-corner-auto-immune-reaction#29492
*) Cereals and pseudo-cereals
As far as vegetables are concerned, raw for enzymes but not at the beginning when your bowels are irritated. We’d better eat them steam-cooked and according to what you can tolerate. Adapt yourself.
As far as pseudo-cereals are concerned, they are admitted but moderately. I advise to limit them once a day, a small portion. Buckwheat and rice do contain antinutrients. Like all cereals.
Not good for endothelial cells. Cereals cause zonulin secretion. Zonulin increases intestinal permeability (leaky gut). Tight junctions are no longer operational (by people suffering from poor digestion).
As far as I’m concerned, I try to limit cereals. Let’s say 2x/3 because I’m not perfect
Additional link if you want to know why grains are not advised.
“Why grains are bad?”
http://www.thepaleomom.com/2012/03/how-do-grains-legumes-and-dairy-cause.html
From “How Do Grains, Legumes and Dairy Cause a Leaky Gut?” Part 1: Lectins.

• Part 2: Saponins and Protease Inhibitors of grains and legumes
  From “How Do Grains, Legumes and Dairy Cause a Leaky Gut?”
  http://www.thepaleomom.com/2012/03/how-do-grains-legumes-and-dairy-cause_29.html

*) The migrating motor complex (MMC) is an electrical and contractile activity of digestive motility which takes place in the inter-digestive periods (between two meals), and interrupted by food intake. Each MMC is accompanied by an increase in gastric, pancreatic and duodenal secretions. They are thought to serve to evacuate contents in the small intestine between meals, and also to transport bacteria from the small intestine into the colon. An alteration of this phase notably favors the development of chronic bacterial colonization of the small intestine, a source in particular of bloating, diarrhea, or even steatorrhea, of the majority of food intolerances. When contractile activity is low, we then speak of lazy intestines. Support and rehabilitation is often necessary, with a prokinetic (Resolor 0.5 mg), initially.

[LucH]

We’ll have to work on## 4 levels:

• Thyroid for energy
• Dysbiosis for microbiome (the microbiote is 70 – 80 % of immunity).
• Leaky gut and foodstuff tolerance
• MMC to get rid of stasis and the disadvantages resulting from bacterial overwhelming. Mind this point (inter-digestive motility) or otherwise we won’t see the end of the tunnel. See beneath for details.

[A Former User]

@LucH said in High-dose thiamine troubleshooting:

Hi, I'm going to try to provide some input:

We’ll have to work on## 4 levels:

• Thyroid for energy

If you supplement thyroid without testing, it can be a big problem. If you take too much thyroid supplementation, you can make yourself hyperthyroid. Hyperthyroidism uses up available thiamine and can cause a thiamine deficiency. Thiamine is needed for oxidative metabolism to work because it acts as a co-enzyme in several steps. Thyroid might be considered the "carburetor" but thiamine is considered the "spark plug". Please see here:
How Can Something As Simple as Thiamine Cause So Many Problems?

If you actually are hypothyroid (I am), it takes time to achieve your optimum dose of thyroid supplementation; it's not a quick simple fix. Lab tests need to be done every 6-8 weeks for a while the supplementation amount is slowly increased as needed. The Broda Barnes book about hypothyroidism is a helpful read.

• Dysbiosis for microbiome (the microbiote is 70 – 80 % of immunity).

suggested reading:
Gastrointestinal Disease and Thiamine

Quick Thoughts: Bacterial Thiamine Synthesis, Dysmotility, and Dysbiosis

Quick Thoughts: Thiamine, Hypoxia, and Bowel Function

• Leaky gut and foodstuff tolerance

I suffered through many years (decades) of disbiosis, leaky gut, many many food intolerances/allergies, high inflammation caused by the endotoxin getting into the bloodstream. I recovered (finally) via high dose thiamine hcl and magnesium glycinate. Ray Peat told me via an email exchange that thiamine and magnesium are needed to heal the gut.

I think that a big part of my own problem was that I had very low stomach acid. High dose thiamine got my autonomic nervous system working again which normalized my stomach acid. All the downstream disbiosis problems resolved quickly once I started taking a high enough dose of thiamine hcl. Low stomach acid can cause big problems.

• MMC to get rid of stasis and the disadvantages resulting from bacterial overwhelming. Mind this point (inter-digestive motility) or otherwise we won’t see the end of the tunnel. See beneath for details.

Please tell me what is "MMC"; thanks. My own gut motility problems resolved when my autonomic nervous system started working properly again.

[BioEclectic]

@mostlylurking said in High-dose thiamine troubleshooting:

Please tell me what is "MMC"; thanks.

Migrating Motor Complex.

[LucH]

@mostlylurking said in High-dose thiamine troubleshooting:

Please tell me what is "MMC"

The migrating motor complex (MMC) is an electrical and contractile activity of digestive motility which takes place in the inter-digestive periods (between two meals), and interrupted by food intake. Each MMC is accompanied by an increase in gastric, pancreatic and duodenal secretions. They are thought to serve to evacuate contents in the small intestine between meals, and also to transport bacteria from the small intestine into the colon. An alteration of this phase notably favors the development of chronic bacterial colonization of the small intestine, a source in particular of bloating, diarrhea, or even steatorrhea, of the majority of food intolerances. When contractile activity is low, we then speak of lazy intestines. Support and rehabilitation is often necessary, with a prokinetic (Resolor 0.5 mg), initially.

[A Former User]

@LucH said in High-dose thiamine troubleshooting:

@mostlylurking said in High-dose thiamine troubleshooting:

Please tell me what is "MMC"

The migrating motor complex (MMC) is an electrical and contractile activity of digestive motility which takes place in the inter-digestive periods (between two meals), and interrupted by food intake. Each MMC is accompanied by an increase in gastric, pancreatic and duodenal secretions. They are thought to serve to evacuate contents in the small intestine between meals, and also to transport bacteria from the small intestine into the colon. An alteration of this phase notably favors the development of chronic bacterial colonization of the small intestine, a source in particular of bloating, diarrhea, or even steatorrhea, of the majority of food intolerances. When contractile activity is low, we then speak of lazy intestines. Support and rehabilitation is often necessary, with a prokinetic (Resolor 0.5 mg), initially.

Thanks. I wasn't familiar with the term and searching for "MMC" yields all kinds of stuff that is not possibly pertinent. Even searching for "MMC medical" yields a plethora of obviously inapplicable results.

Gut motility and its control
"Smooth muscle cells in the GI tract are bundled together and are linked by gap junctions that allow the flow of electrical signals between the cells, allowing them to contract as a functional syncytium. Control of the muscles, and thus gut motility, is complex and is co-ordinated by the autonomic nervous system, hormones and other mechanisms intrinsic to the GI tract. In this way, the GI tract is able to respond to changes in the luminal environment caused by food intake."

also this one:
"Central nervous control of the MMC. Currently, there
is no doubt that the nervous control of the MMC is crucial for its initiation and modulation. It comprises the evident neural responses due to neuromediator’s action and interplay among NANC-related central and peripheral modulators as well as the hormones (principally peptide hormones) [3, 4]. Central nervous control of the stomach and small intestine comprises mainly the effects mediated by extrinsic innervation of these regions, i.e. vagal and sympathetic nerve-related influences (Fig. 1). These actions mediated by the efferent nerves occur as the response to central effects and peripheral (afferent) stimuli from the gastrointestinal tract. One of the incompletely resolved questions is: what is the precise role of the central effects vs. the peripheral nervous influences in the control of the MMC cycle? There is increasing knowledge focusing on the role of the central nervous system in the control of the MMC that comprises the scientific evidence derived from physiological, pharmacological, surgical and clinical experiments and observations."

How Can Something As Simple as Thiamine Cause So Many Problems?
"The lower part of the brain, called the brainstem, is a like computer, controlling the most basic aspects of survival, from breathing and heart rate, hunger and satiety, to fight or flight and reproduction. This computer-like function within the brainstem is called the autonomic system (ANS). The ANS together with the limbic system act in concert to regulate our most basic survival functions and behaviors. Both require thiamine to function."

Here's a video from EONutrition:
Is Thiamine Deficiency Destroying Your Digestive Health? Why B1 Is ESSENTIAL For Gut Function

[A Former User]

@LucH said in High-dose thiamine troubleshooting:

Support and rehabilitation is often necessary, with a prokinetic (Resolor 0.5 mg), initially.

about Resolor:
"How does Resolor work? The active substance in Resolor, prucalopride, is a ‘5-HT4 receptor agonist’. This means that it works like a substance in the body called 5-hydroxytryptamine (5-HT, also known as serotonin) and attaches to receptors for 5-HT in the gut called ‘5-HT4 receptors’.

When 5-HT binds to these receptors, it normally stimulates movement in the gut. In the same way, when prucalopride attaches to and stimulates these receptors, it increases this movement and allows the bowels to empty faster."

Ray Peat on serotonin:
Serotonin, depression, and aggression: The problem of brain energy

When I was thiamine deficient, I was extremely sensitive to serotonin. This was probably because thiamine is needed to clear serotonin from the brain. Taking something that increases serotonin when thiamine deficient is not something I would do.
Effect of thiamine deficiency on brain serotonin turnover

[LucH]

@mostlylurking

I agree with your analyze on excess serotonin and 5-HTP (targeting SSRI, thus increasing central nervous system synthesis of serotonin).
SSRI = Selective Serotonin Reuptake Inhibitor.
Saying that, prucalorid is taken, not as a laxative – at the usual dose of 2 mg – but as a stimulus (0.5 mg resolor). The dose is very weak but sufficient for re-educating a lazy gut.
Here we’re trying to find a solution for colonic motility dysfunction. And the solution has not to be found with a laxative. This is not because of a lack of electrolytes, fibbers or exercises. By the way, 30 grams fibbers is needed, with soothed fibbers (progressive).
When suffering from insufficient electrical contractile bowel movements, between 2 meals, we aren’t targeting a problem of transit. The muscle contractions are called peristalsis. This process must be re-educated. Of course, the IBS problem (high-amplitude propagating contractions) must be taken into account. First calming down irritation, afterwards stimulation of the stasis.
Note that when I took resolor 0.5 mg, I took it 2 hours before bedtime (3-4 days adaptation period).
A box of 28 tablets cut into two parts = 56 days of treatment (cut with a sharp kitchen knife). No need for a second box.
Once a day for stools wasn’t enough to get rid of excess / unbalanced intestinal bacteria. Some bacteria had nothing to do in the second part of the colon.
The problem in now under control, with the help of diamine oxidase. Too much histamine. (NaturDAO, 1 000 000 units).
Note: The warning concerns the usual employment to a high dosage of 5-HTP and against an excess of serotonin. The excesses are obviously counterproductive. Here, it is rather a homeopathic treatment / dosage. The difference between a poisoning treatment and a treatment that stimulates. Only the dose makes the poison. I would add the duration too.

[A Former User]

@LucH said in High-dose thiamine troubleshooting:

@mostlylurking

I agree with your analyze on excess serotonin and 5-HTP (targeting SSRI, thus increasing central nervous system synthesis of serotonin).
SSRI = Selective Serotonin Reuptake Inhibitor.
Saying that, prucalorid is taken, not as a laxative – at the usual dose of 2 mg – but as a stimulus (0.5 mg resolor). The dose is very weak but sufficient for re-educating a lazy gut.
Here we’re trying to find a solution for colonic motility dysfunction. And the solution has not to be found with a laxative. This is not because of a lack of electrolytes, fibbers or exercises. By the way, 30 grams fibbers is needed, with soothed fibbers (progressive).
When suffering from insufficient electrical contractile bowel movements, between 2 meals, we aren’t targeting a problem of transit. The muscle contractions are called peristalsis. This process must be re-educated. Of course, the IBS problem (high-amplitude propagating contractions) must be taken into account. First calming down irritation, afterwards stimulation of the stasis.
Note that when I took resolor 0.5 mg, I took it 2 hours before bedtime (3-4 days adaptation period).
A box of 28 tablets cut into two parts = 56 days of treatment (cut with a sharp kitchen knife). No need for a second box.
Once a day for stools wasn’t enough to get rid of excess / unbalanced intestinal bacteria. Some bacteria had nothing to do in the second part of the colon.
The problem in now under control, with the help of diamine oxidase. Too much histamine. (NaturDAO, 1 000 000 units).
Note: The warning concerns the usual employment to a high dosage of 5-HTP and against an excess of serotonin. The excesses are obviously counterproductive. Here, it is rather a homeopathic treatment / dosage. The difference between a poisoning treatment and a treatment that stimulates. Only the dose makes the poison. I would add the duration too.

I think that the idea that the "lazy gut" must be "reeducated" is pretty silly. I've been through this problem myself for many years and now I've recovered. I did not "reeducate" my "lazy gut". I recovered by supplementing enough thiamine so that my autonomic nervous system could function normally. "insufficient electrical contractile bowel movements" are insufficient because the autonomic nervous system is not sending the electrical impulses via the vagus nerve needed for peristalsis to happen. It's a communication problem between the brain and the intestine via the vagus nerve.

Kindly read the articles that I posted earlier.

If you want to improve transit time, Ray Peat liked to recommend cascara sagrada.
Cascara, energy, cancer and the FDA's laxative abuse
"If someone thinks of constipation as the result of a lack of neuromuscular stimulation, then it might seem reasonable to design a drug that intensifies the contractions produced by one of the natural transmitter substances, such as serotonin, histamine, or acetylcholine. That’s apparently what Novartis did, with tegaserod, a drug that increases the bowel’s sensitivity to serotonin. That drug, called Zelnorm, was approved by the FDA in 2002, after a couple of years of publications praising it. At the time of its approval, there was already evidence that people using it were more likely to have abdominal surgery, especially for gallbladder disease, and there was doubt about its effectiveness."

[LucH]

@mostlylurking said in High-dose thiamine troubleshooting:

by supplementing enough thiamine so that my autonomic nervous system could function normally. "insufficient electrical contractile bowel movements" are insufficient because the autonomic nervous system is not sending the electrical impulses via the vagus nerve needed for peristalsis to happen. It's a communication problem between the brain and the intestine via the vagus nerve.

The reasoning is good. Thanks for developing.
Could you give details about your "protocol". The posology of thiamin: posology and duration, please. It could help other readers too. + interaction with B2, I suppose.
I had to stop high dose thiamin because of histamine.
Next post for details to come, after your answer, to avoid interference
Thanks for comprehension.

B1 / Thiamine Causing Histamine Issues

[A Former User]

@LucH said in High-dose thiamine troubleshooting:

@mostlylurking said in High-dose thiamine troubleshooting:

by supplementing enough thiamine so that my autonomic nervous system could function normally. "insufficient electrical contractile bowel movements" are insufficient because the autonomic nervous system is not sending the electrical impulses via the vagus nerve needed for peristalsis to happen. It's a communication problem between the brain and the intestine via the vagus nerve.

The reasoning is good. Thanks for developing.
Could you give details about your "protocol".

I follow Dr. Costantini's protocol for thiamine hcl dosage amounts. The amount is based on body weight. I take 1 gram of thiamine hcl mid morning and 1 gram of thiamine hcl mid afternoon. I also take 100mg riboflavin + 100mg niacinamide 4Xday. I take 3100mg of magnesium glycinate divided into 2 doses/day(=400mg pure magnesium). I also take a little biotin, a little b5, a little b6, some k2, some D3, some pregnenolone, some progesterone, some ground eggshells, some selenium, a little NAC, and some zinc daily. I'm relying on orange juice and bananas for my potassium for now; I'm considering trying some potassium bicarbonate though.

High dose thiamine is believed to use up riboflavin, potassium, zinc; I take the other things after reading about them in Ray Peat's written articles.

The posology of thiamin: posology and duration, please. It could help other readers too. + interaction with B2, I suppose.

I rely on the knowledge of Dr. Costantini for dosage (see link above). I'm taking this amount of thiamine hcl for the foreseeable future; I have mercury toxicity with causes high oxidative stress which uses up thiamine. Mercury is extremely toxic and cannot be safely chelated out of the body with currently available protocol.

I consider my vitamin protocol to be a continuing project, due to my heavy metal toxicity; the protocol is not going to "cure" me because the mercury is not going away. Although thiamine is believed to chelate heavy metals (like lead), I think it would not be wise for me to assume that it chelates mercury. Mercury has high affinity for selenium and good results have been seen using selenium+NAC (makes selenocysteine) to resolve mercury in early exposure. My issue is chronic as the exposure happened from childhood amalgams + amalgam removal with zero safety protocols when I was in my 20's; I'm 74 now. I am hypothyroid and am being successfully treated by an elderly endocrinologist with an optimized dose of prescription NP Thyroid by Acella.

Here is an article about the use of thiamine + riboflavin:
Thiamine and Riboflavin for Chronic Fatigue I was diagnosed with CFS around 2000 and suffered from those symptoms for around 30 years. I no longer have those symptoms.

Elliot Overton has mentioned that high dose thiamine can use up riboflavin. I think it was in a video, but I don't remember which one. I'm pretty sure it was one of these.

You might find these videos with Elliot of interest:
The Art & Science of Mega-Dose Thiamine Lecture: Part 1
How to Apply High-Dose Thiamine Protocols in Clinical Practice: Part 2

I had to stop high dose thiamin because of histamine.
Next post for details to come, after your answer, to avoid interference
Thanks for comprehension.

B1 / Thiamine Causing Histamine Issues

Although I lived through decades of strong histamine reaction caused by an immune system run amuck with almost universal reaction to foods and environmental toxins, I no longer have those symptoms. I attribute my recovery to resolving high estrogen via progesterone plus my high thiamine hcl protocol. You can search for "histamine and estrogen" for further reading. Here's an article that touches on the immune system and thiamine.

This Ray Peat article may be helpful:
Serotonin, depression, and aggression: The problem of brain energy
"Serotonin and estrogen have many systematically interrelated functions, and women are much more likely to suffer from depression than men are. Serotonin and histamine are increased by estrogen, and their activation mimics the effects of estrogen. Serotonin is closely involved in mood disorders, but also in a great variety of other problems that affect women much more frequently than men. These are probably primarily energy disorders, relating to cellular respiration and thyroid function. Liver disease and brain disease, e.g., Alzheimer’s disease, are both much more common in women than in men, and serotonin and estrogen strongly affect the energetic processes in these organs. Liver disease can increase the brain’s exposure to serotonin, ammonia, and histamine. It isn’t just a coincidence that these three amines occur together and are neurotoxic; they are all stress-related substances, with natural roles in signaling and regulation."

Here is a list of articles found by searching for "histamine" on hormonesmatter.com.

[LucH]

@mostlylurking
Thanks for developing. I appreciate.
I'm going to read further (links) and come back soon after when digested.
See you later.
Correcting Mast Cell Activation Syndrome - Histamine Intolerance - Mastocytosis - Biologix Center for Optimum Health
https://biologixcenter.com/allergies/correcting-mast-cell-activation-syndrome-histamine-intolerance-mastocytosis/
This group does extensive research on histamine and is quite reputable. They list Thiamine/B1 as being a liberator and DAO blocker with certain types of administration:
HIT > Therapy > Medicaments
https://www.histaminintoleranz.ch/en/therapy_medicaments.html#antihistamines
*1 => Thiamin as histamin liberator and DAO inhibitor
Sattler 1985 (PDF with reference on histamine active substance)
Sattler J, Hesterberg R, Lorenz W, Schmidt U, Crombach M, Stahlknecht CD.: "Inhibition of human and canine diamine oxidase by drugs used in an intensive care unit: relevance for clinical side effects?" Agents Actions. 1985 Apr;16(3-4):91-4.
https://pubmed.ncbi.nlm.nih.gov/3925736
(Liste unverträglicher Medikamente (DAO-Hemmer))
Büttiker (same PDF with reference on histamine active substance)
*) Lack of magnesium
Specific change of histamine metabolism in acute magnesium-deficient young rats. - PubMed - NCBI
*1 ## Incompatible medicaments
Histamine liberators
Many agents in medicaments (active substances as well as additives) have the negative effect that they cause mast cell degranulation which leads to release of histamine and other mast cell mediators. They have to be avoided where ever possible according to the agreement with your physician.
DAO-Inhibitors
Many agents in medicaments have the negative effect that they are diamine oxidase inhibitors or inhibitors of other histamine degrading enzymes. They have to be avoided where ever possible according to the agreement with your physician.
List of incompatible active substances in medicaments
This list needs to be completed. Please let us know your experiences with other substances.
Set in excerpt (LucH): Acetyl-cysteine (NAC), aspirin, many barbiturates, bile acid, codeine, gelatin (bone broth), NSAID, quinine, thiamin and tyramine.

[A Former User]

@LucH suggested reading: Reversing Mast Cell Activation and Histamine Intolerance Summit

[LucH]

Hi,
I said I would come back and give a comment. I did some research and compile what I’ve understood, so far. An input would be appreciated, if you feel so and have time to deal with. Too many people struggle with so-called auto-immune pathologies when we don’t understood the etiology entirely. Partly true but …
This information could give an alternative, possibly the opportunity to perceive an improvement, if the tissues are not too destroyed. We won’t recuperate the lost synapses but as we only use 10 % of our brain, we are able to bypass and create new connections.

Anti-Stress & Neuro-Protective Effects of Thiamine (B1)

Mitochondrial Energy Uploaded thanks to Optimized Enzyme Communication

Key points
• Thiamine (B1) has also neuro-protective effects: Brain & Digestive System.
• B1 must be seen as the fuel for a power plant the bioavailability of which is dependent on enzyme functionality.
• Oxidative and chronic low-grade inflammation induce a metabolic block.
• When giving supra-physiological doses of thiamin to the cells, enzymes come back to normal operating state.
• Universal anti-stress properties of thiamine.
• Impact on mitochondrial respiration: link with ATP production.
• The role of thiamine insufficiency in lower brain dysfunction.
• Connection between the brain, the digestive system and the vagus nerve: Dysautonomia and adaptation to the stress environment when fuel is re-loaded.
• Understanding nutritional deficiencies & functional insufficiencies / dependencies.
Cases reports on pathologies: Energy, SIBO, diabetes, fibromyalgia, Parkinson’s, CVD, thyroiditis, multiple sclerosis, etc.

Full post on this link, with explanations, figures, studies links and case reports if you want details and see how to manage in practice.
https://mirzoune-ciboulette.forumactif.org/t2045-english-corner-anti-stress-neuro-protective-effects-of-thiamine-b1#29712

[LucH]

Remind: 3 pillars of thiamine repletion

1. Identify which vitamin B1 your body needs / is accepted by your metabolism (transport capacity, genetic deficiency).
2. At least these cofactors are needed: magnesium, potassium and sodium (in proportions, for the two last ones).
3. Some vitamins handles as B-vitamin cofactors. Interaction with other B-vitamins.
   Figure: circle with Vitamins B interaction (B1 B2 B6 Biotin, underlined in yellow)
   

[A Former User]

@LucH said in High-dose thiamine troubleshooting:

Hi,
I said I would come back and give a comment. I did some research and compile what I’ve understood, so far. An input would be appreciated, if you feel so and have time to deal with. Too many people struggle with so-called auto-immune pathologies when we don’t understood the etiology entirely. Partly true but …

I was diagnosed with rheumatoid arthritis in 2014, the result (I believe) from severely blocked oxidative metabolism caused by hypothyroidism + thiamine deficiency. I recovered via optimized prescription desiccated thyroid medication + some thiamine.

I think that the "auto-immune pathologies" are the result of blocked oxidative energy. I think unblocking/optimizing oxidative energy is curative. If the body has the needed cellular energy, it can heal itself.

This information could give an alternative, possibly the opportunity to perceive an improvement, if the tissues are not too destroyed. We won’t recuperate the lost synapses but as we only use 10 % of our brain, we are able to bypass and create new connections.

Yes. I experienced my brain rewiring itself 1995-1997 after organo-phosphate insecticide poisoning in 1993. Learning a new creative skill that required right brain function facilitated the healing/rewiring.

Anti-Stress & Neuro-Protective Effects of Thiamine (B1)

Mitochondrial Energy Uploaded thanks to Optimized Enzyme Communication

Key points
• Thiamine (B1) has also neuro-protective effects: Brain & Digestive System.

Yes. I think that the optimized cellular energy level that thiamine facilitates when working as a co-factor for several enzymes in the Krebs cycle restores the body's balance on the cellular level. Getting the body's energy level working on the cellular level as it is intended is neuro-protective. Think of it as restoring the electrical current that connects the body's cells so that they work in harmony.

• B1 must be seen as the fuel for a power plant the bioavailability of which is dependent on enzyme functionality.

I think it is more accurate to view B1 as a facilitator that allows the fuel (glucose+oxygen) to burn optimally. Dr. Lonsdale's explanation that thiamine acts like a spark plug is a helpful concept.

• Oxidative and chronic low-grade inflammation induce a metabolic block.

The blockage of oxidative metabolism on the cellular level causes inflammation (lactic acidosis). First comes the malfunctioning of the oxidative metabolism (due to thiamine deficiency/functional blockage), which results in an inefficient fuel burn with the end product being lactic acid instead of carbon dioxide. The lactic acid is highly inflammatory. However, it's a double edged sword because high oxidative stress from a poison/irritant like heavy metals deplete thiamine which results in high inflammation.

• When giving supra-physiological doses of thiamin to the cells, enzymes come back to normal operating state.

Yes. Flooding the system with thiamine gets the enzymes to work properly even if there is a weak affinity between enzyme and thiamine. See this video by Elliot Overton.

• Universal anti-stress properties of thiamine.

Yes. I believe thiamine resolves oxidative stress. I think that if you suffer from high oxidative stress (as I have via mercury poisoning) that you will deplete thiamine stores and will benefit from high dose thiamine which will resolve the oxidative stress. See this article: The importance of thiamine (vitamin B1) in humans (search for Oxidative Stress in the article). also see this article: The impact of oxidative stress in thiamine deficiency: A multifactorial targeting issue

• Impact on mitochondrial respiration: link with ATP production.

Yes. Thiamine is required as an enzyme co-factor in oxidative metabolism to make ATP.

• The role of thiamine insufficiency in lower brain dysfunction.

Yes. The lower brain is extremely sensitive to thiamine deficiency which results in problems with the autonomic nervous system. This autonomic nervous system concept encompasses a LOT of things. For example, I suffered for decades from scoliosis (curvature of the spine) because the electrical impulses that controlled the muscles on either side of my spine were not equal in power. I recovered via high dose thiamine hcl. See this article: What Is Scoliosis?

• Connection between the brain, the digestive system and the vagus nerve: Dysautonomia and adaptation to the stress environment when fuel is re-loaded.

Thiamine restores the function of the vagus nerve and resolves dysautonomia. The autonomic nervous system needs the electrical connectivity that oxidative metabolism provides via ATP production. No ATP, no electrical connectivity = dysautonomia.

• Understanding nutritional deficiencies & functional insufficiencies / dependencies.
Cases reports on pathologies: Energy, SIBO, diabetes, fibromyalgia, Parkinson’s, CVD, thyroiditis, multiple sclerosis, etc.

Full post on this link, with explanations, figures, studies links and case reports if you want details and see how to manage in practice.
https://mirzoune-ciboulette.forumactif.org/t2045-english-corner-anti-stress-neuro-protective-effects-of-thiamine-b1#29712

Good write up, lots of info. Helpful link!

[A Former User]

@LucH said in High-dose thiamine troubleshooting:

Remind: 3 pillars of thiamine repletion

1. Identify which vitamin B1 your body needs / is accepted by your metabolism (transport capacity, genetic deficiency).

Yes, it is important to learn which thiamine would work best for you. For example, some people do very well on TTFD thiamine because it is supposed to get into the body easier and the cells easier than some other kinds. However, if you have poor glutathione status, which can happen if you have high oxidative stress, you will probably react badly to TTFD because it uses glutathione in its chemical function. I had this problem myself and so I take high dose thiamine hcl instead which works well for me.

2. At least these cofactors are needed: magnesium, potassium and sodium (in proportions, for the two last ones).
3. Some vitamins handles as B-vitamin cofactors. Interaction with other B-vitamins.

I think that it is helpful to understand that if you massively improve the basic function of creating ATP via oxidative metabolism, whether it's from taking thyroid supplement or thiamine supplement or both, the other necessary vitamins and trace minerals are going to get used more too, simply because the factory is back up and running. This can cause other deficiencies so it is helpful to research to learn which nutrients might be most susceptible to deficiency. For me these include: niacinamide, riboflavin, biotin, magnesium, potassium, selenium, zinc.

Blood testing is a really good idea because this can get complicated and confusing. Also keep in mind that too much thyroid supplement can result in hyperthyroidism which can cause a thiamine deficiency which results in symptoms identical to hypothyroidism so blood testing is needed to determine what is really going on.

Figure: circle with Vitamins B interaction (B1 B2 B6 Biotin, underlined in yellow)