I would stop trying to chase what individual supplement you should take unless you want to get a full nutrient panel... which is expensive, turnaround time is a couple weeks at least, and full is really a misnomer because no panel I've found literally tests everything. Thiamine clears the system pretty quickly, especially a high dose of supplement, so the worst should be over. If you can pin down some specific symptoms that might point to a specific deficiency, that would help, but it's hard if you mostly just feel stressed, off-kilter, general bad, etc. It's so hard to find supplements in sane doses that you're effectively mega-dosing everything you try in an attempt to fix bad after effects of a super-megadose of something.

I'm not a doc or any kind of health-related professional. But having been through a similar experience with thiamine, what I wish I would have done first is just focus on having the most balanced, nutrient-dense diet possible, especially in terms of balanced macros, and avoiding thiamine-fortified foods. In particular I wish I could have gotten myself to eat beef liver, which is ofc a good source of B vitamins but not particularly high in thiamine, and it IS a very good source of molybdenum. The nutrient panel I got didn't test molybdenum so I didn't end trying it until months after my thiamine troubles when I was feeling mostly back to normal, but it did seem helpful. I don't eat legumes or dairy so I really should be eating liver, just haven't found a palatable method yet.

Sorry you're experiencing this. Chris Masterjohn has a Substack article about the potential pitfalls of high-dose thiamine supplementation. The tl;dr is that it can cause sulfur issues, cause depletion of other nutrients, or stress weaknesses/defects in your energy metabolism processes. After my own bad thiamine experiences I got a lot of nutrient testing as well as experimenting with molybdenum, etc. I'm not sure any of it helped as much as time though.

I can add more tomorrow if you are interested. Hope you are doing alright.

I had a CT with iodine contrast last week. Afterward I initially felt great actually, really warm and energetic. But this week I feel the worst I've felt in years. Very tired, weak, anhedonic, etc. Suddenly have a very obnoxious double chin! Temp is 97.7 now and I can only get it over 98 if I sugar binge and it doesn't last very long.

I do take small amounts of T3 so I figure I'll just increase my dose by a little bit every day until my temps pop back up. Apparently it can take a month or more after a dose of iodine contrast to get back to baseline iodine levels. I didn't even know ahead of time that I would be getting contrast with the CT to be able to make an informed decision about it. Sigh.

@LucH

Thank you for the interest! Actually for a long time I wouldn't have called my gut sensitive--just constipated. Slow slow bowels my whole life. I have also had ENERGY problems my whole life so they are probably related one way or another. About 5-6 years ago though I started having gastritis, supposedly caused by h.pylori, and things have been much funkier and more sensitive since then in the gut department. Antibiotics for the h.pylori eradicated the bacteria but didn't solve the gastritis--however a low fodmap diet did and I've been eating low fodmap since 2020 as a result. My gut is very sensitive to anything fermentable and/or fibrous. If I eat more than incidental amounts or frequency of FODMAPs I get gastric pain and fibromyalgia symptoms. If I follow my restricted diet my symptom set is more chronic fatigue, very little pain. The only thing that helps the constipation though is miralax. All of this low energy and constipation is one of the main things that had me interested in the high-dose thiamine therapy.

I am a fan of collagen powder although lately I'm developing a bit of an aversion to it for some reason and having trouble taking it as consistently. I do take either magnesium glycinate or citrate regularly. I have tried glutamine before but it had an overstimulating, irritable effect on me unfortunately. I think I likely have dysbiosis in the form of SIBO given the fodmap intolerance but unfortunately have had trouble finding a competent doctor in my area to help treat it. I like theanine at bedtime some nights but haven't noticed any correlation with gut function, but maybe if I took it regularly instead of as-needed for sleep?

Re: thyroid, since that would be a logical next question: I'm currently taking 4 drops of Tyromix daily. It's hard to track my temps bc I often run a low-grade fever, which is common in chronic fatigue, but recently the fever has left and I've been around 98.05, so I'm interested in upping the thyroid, just trying to decide what amount to try. I was first diagnosed mildly hypothyroid in 2008 and prescribed 50mcg levothyroxine, which takes my TSH from 4.5 down to around 1.3. I've been DIY-ing mixing T3/T4 for the past couple years and don't have up to date labs atm.

Thank you both for the reply. I do seem to have some underlying issues with my liver that I can't quite figure out so perhaps it's an issue with liver processing or the B1 taxing poor glycogen storage to its limit with energy demand. I have been taking progesterone for a few years and thyroid since 2008 (switched to T4/T3 combo for about two years now). My digestion is still super out of sorts... I think the stick to basics/low and slow rec is a good one, so I'm thinking I might take another go at daily carrot salad--small amounts for my silly sensitive gut--and see if that can help my digestion and liver out, before I try other things.

Hey folks,

I've recently started experimenting with high-dose thiamine (2grams Thiamine HCL/day). I first tried this a couple weeks ago for about 5 days. I experienced initial euphoric energy that segued into high stress, irritable energy. After about a week off I tried a gram again this morning, and again had initial calm, clear-headed, happy feelings--honestly almost reminiscent of a microdose of mushrooms, with my vision in particular becoming very clear and pleasant. But then before long it faded to irritability again. I should mention that it's pretty typical for me to be irritable but it's been helped since taking progesterone and eating more calories and more sugar. This irritability after a few days of thiamine was about as bad as my irritability ever gets so, definitely worse than it's been lately.

For context, I'm attempting to treat more-or-less lifelong chronic fatigue issues. The initial feeling from the high dose thiamine is definitely like something is going right, which I haven't felt from lower (500mg) doses or from any other B vitamin. So I'm really interested to figure out how to make it work past the first day. Does anyone have ideas of what is making it so that I'm not maintaining that initial benefit from thiamine? I'm not sure what all is considered necessary co-factors with thiamine. I do take magnesium but could possibly need to take more ? I take a multi most days, niacinamide most days, and took 500mg panthothenic acid with the thiamine this morning.

Any suggestions would be much appreciated, thanks.