Heart failure report showing t4 solo vs t4:t3 in action for full recovery (edema too)
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329947/
Here's a great example where t4 alone failed and adding t3 succeeded
some tissues like the heart are very vulnerable to low T3 signalling (aka hypothyroidism) because its reliant on other cells converting t4-t3 well enough for its t3 supply (deiodinase 1), due to it having low rates of t4 import / conversion.
Here a 16 yr old boy had severe heart problems due to hypothyroidism & they were considering a heart transplant. A high dose of t4 only didn't improve his heart (t3 still low).
When they added t3 (and actually lowered the t4 dose too) his heart function improved, then started recovering well by 6 weeks with edema resolving, and over the months after discharge actually completely regenerated to healthy functioning, no heart replacement necessary. once his health was fixed he no longer needed the t3. (by 3 yrs still good but TSH up and LEF down a little, was on t4 only by then) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10329947/The conversion of T4, a prohormone, to T3 takes place in the tissues of specific organs and most of the available serum T3 is provided by enzymatic deiodination of T4 in the liver and kidney.
The enzyme, 50 -monodeiodinase, removes one iodine atom from T4 to produce T3.
Factors that impair the activity of this enzyme lead to decreased levels of T3 in the serum and therefore, in dependent tissues
Insufficient deiodination of T4 to T3 can cause levels of T3 to be low, when TSH
and T4 are within the normal range. {There's also deiodinase 3 which can directly inactivate t3}
Cardiac tissue does not appreciably convert T4 to T3; therefore, the heart is dependent on available serum T3. our data suggest that T4 is not transported into the heart. adding 12.5mcg t3 to same dose of 150mcg t4 for 3 days initially made worse
. lowering t4 to 50mcg with 12.5mcg t3 = heart improved over 2 weeks
. then adding an extra 6.25mcg t3 and 25mcg t4 , at 6 weeks heart function noticeably improved. edema resolved. Induced mild hyperthyroidism with TSH suppressed to 0.05 (AND TO IMPROVE HEART FUNCTION), with elevated t3 2.55 and normal t4.
. Discharged at 25mcg t3 and 200mcg t4 stayed on t3 for 2 months. then stayed on lower t4. by 6 months LEF normalized heart function pretty much normalized. at 1yr MR grade normalized too.Although T4 monotherapy has become a standard treatment for hypothyroidism, his cardiac function did not improve with T4 monotherapy despite normalization of free T4 level. He was treated with T3 and T4 combination therapy, and his symptoms and cardiac function gradually improved three weeks after initiation of combination therapy, and he fully recovered after 6 months.
"Self-organizing systems decay only if they have assimilated inertia, and — with a little support of the right kind— the centers of degeneration can become centers of regeneration."
"world," as a source of new perceptions
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@cs3000
Nice find!Just the thyroid working, using a T3:T4 combination, was enough to make the heart go from needing to be replaced to recovering fully.
If the heart were replaced, he would still be having a risk of heart failure subsequently because really, the heart's condition wasn't the real issue.
Parts replacement addiction is a problem, not just with organ transplants, but also with cars and devices such as computers and smartphones in a disposable economy that is trained to replace associated assemblies and organs instead of repair.
Many doctors share alike this mentality with car mechanics and Apple store "geniuses."
But the tide is not on our side as the establishments and institutions and even the AI hegemony will favor simplification with the modular mindset instilled with assembly and organ replacement being where we are headed. With education driven to develop a culture of less thinking and more following, the ability to McGyver things is eroding.
Which is why having an independent mind capable of critical thinking and nuance, developed my oneself and at home, with parental and grandparental and family molding to counter the Talmudist-influenced beehive culture of our institutions.
By the way, I have fully recovered from heart failure but thanks to the knowledge gained from the bioenergetic orientation of being immersed in a thought subculture revolving around Ray Peat's writings I am back to mybold healthy thriving self.
Temporal thinking is the faculty that’s
engaged by an enriched environment, but it’s
wrong to call it “thinking,” because it’s simply
the way organisms exist... - Ray Peat Nov 2017 Newsletter -
Interesting. Maybe in 30 years or so T3+T4 will again become a dominant standard of care.
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This could be quite a profound intervention for any poison mainliners continuing to exhibit cognitive/character deviance. And more generally. People relentlessly holding tonal distortions whether they received that concoction or not.
Somewhere between wearable magnetocardiography sensors and statistical inferencing, identifying this will become a dark art.
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@yerrag said in Heart failure report showing t4 solo vs t4:t3 in action for full recovery (edema too):
By the way, I have fully recovered from heart failure but thanks to the knowledge gained from the bioenergetic orientation of being immersed in a thought subculture revolving around Ray Peat's writings I am back to mybold healthy thriving self.
