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    Proline restores mitochondrial function and reverses aging hallmarks in senescent cells

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    • DavidPSD
      DavidPS
      last edited by DavidPS

      Senescent cells exhibit diminished proline biosynthesis and benefit from proline supplementation. Proline promotes mitophagy by activating AMPKa and upregulating Parkin, improving mitochondrial function, and ameliorating aging hallmarks. Parkin is necessary to mediate the effects of proline and reverse aging hallmarks, but it is not sufficient.

      Proline restores mitochondrial function and reverses aging hallmarks in senescent cells - 2024

      “All things are poison and nothing is without poison; only the dose makes a thing not a poison.” - Paracelsus (c. 1493–1541)
      ☂︎

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      • DavidPSD
        DavidPS
        last edited by

        Foods With Most Proline

        d79ef99a-0fa6-4429-b6a7-3e24124dad2d-image.png

        “All things are poison and nothing is without poison; only the dose makes a thing not a poison.” - Paracelsus (c. 1493–1541)
        ☂︎

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        • Johann2547J
          Johann2547
          last edited by

          Does proline act most beneficial on an empty stomach or as part of a food?

          DavidPSD 1 Reply Last reply Reply Quote
          • DavidPSD
            DavidPS @Johann2547
            last edited by

            @Johann2547 - I do not know. Perhaps, in an empty stomach it would have no competition.

            “All things are poison and nothing is without poison; only the dose makes a thing not a poison.” - Paracelsus (c. 1493–1541)
            ☂︎

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            • W
              wester130 @DavidPS
              last edited by

              @DavidPS how similar is proline to glycine??

              I find glycine makes me sleepy

              is this a better alternative?

              DavidPSD 1 Reply Last reply Reply Quote
              • DavidPSD
                DavidPS @wester130
                last edited by

                @wester130 - I do not know. I get my proline from my diet.

                “All things are poison and nothing is without poison; only the dose makes a thing not a poison.” - Paracelsus (c. 1493–1541)
                ☂︎

                W 1 Reply Last reply Reply Quote
                • W
                  wester130 @DavidPS
                  last edited by

                  @DavidPS it also solves heart disease in the Linus Pauling protocol

                  it's an interesting substance

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