Glucose loading cures everything?
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@evan-hinkle said in Glucose loading cures everything?:
@Insomniac fructose converts to glucose in an oxidative metabolism. This is what I think is the missing piece for everyone here and at the RPF.
No. Fructose does not need conversion to glucose to be metabolized. Actually, fructose is more easily absorbed and metabolized than glucose. You can find many articles in his website (or used to be, if his website is gone) www. raypeat.com about fructose
So, you need oxidative phosphorylation, (thyroid supplementation) or glucose. 2 options, same outcome.
Not 'or' but 'and' glucose ( and oxygen, and more).
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@ThinPicking said in Glucose loading cures everything?:
@yerrag said in Glucose loading cures everything?:
When tissues cannot absorb and metabolize glucose, why does glucose loading work nonetheless. Perhaps it's because when blood glucose gets high, it triggers the polyol pathway, where glucose is converted to fructose. Unlike glucose, fructose is more easily absorbed and metabolized by tissues.
Evan also mentions hydration of his eyes and better sleep some way up. Along with the teeth thing. My best bet remains that it's resolving a kind of edema. Drawing in structure, raising metabolism, which also produces structured water inherently. I would say filling in edema with structural components, but he also reported some welcome weight loss.
I just wonder at what cost. If this isn't created by or refined from nature. Why not the fructose. Or why would there be a preference for this.
The edema angle is spot on, although the mechanism I can't really explain and remains vague. But a lot has to do with having good metabolism that plays a big role in making the cell acidic internally and alkaline externally in the ECF. This keeps the cell structure stable and distinct and free from being contaminated, so to speak, from the extracellular milieu. The cell won't be bloated with water, for example. A lot of this has to do with the energy in the cell creating structured water to enable a strong barrier that conventional biology calls the cell membrane. In such a state, you can create an osmotic balance that keeps the eye fluids from getting to feel dry. Sleep is better the brain isn't under stress as energy flows well with the mitochondria producing the energy adequately to power restful sleep. As for the teeth, it may go as far as the cell being in optimal metabolic state, augurs well for the continued osteooblast activity in building structure in bones, with the abundance of CO2, and sufficient dietary calcium to strengthen teeth - as teeth isn't being leached due to osteoclast activity being turned off.
All this has to be associated with enabling oxidative phosphorylation, as glucose is being used heavily optimally.
Temporal thinking is the faculty that’s
engaged by an enriched environment, but it’s
wrong to call it “thinking,” because it’s simply
the way organisms exist... - Ray Peat Nov 2017 Newsletter -
@ThinPicking said in Glucose loading cures everything?:
@ThinPicking said in Glucose loading cures everything?:
But there's some sort of concert going on.
@ThinPicking said in Are Polls a Good Idea?:
Is it actually possible to substitute in either direction. Maybe just a temporary lack of control and engagement in some. Many ways a person can delude themselves. Misappropriate their condition and capability.I don't know. So this isn't an objection. I'll be creating some posts on the subject at some point.
https://www.mdpi.com/1424-8220/22/23/9115
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075501/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10002343/
https://www.ahajournals.org/doi/10.1161/STROKEAHA.123.040499
https://www.sciencedirect.com/science/article/abs/pii/S0306987719307145
https://www.sciencedirect.com/science/article/pii/S1568163721002865
https://www.frontiersin.org/articles/10.3389/fpsyg.2014.00278/fullFor the liver fixation of the Vitamin A toxicity crowd.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981187/
For their aversion to fructose.
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.695486/full
To add to the thought. This whole thing may be conditionally true for their camp. If they're carrying a kind of (resolvable, always resolvable) cardiac injury. So this alternative "protocol" may slow to a crawl, what would be a demise of "natural causes". And retain incomplete but good neurological function.
I'm out on a limb here. This is quite fringe. Anyone willing, please muse on it and critique.
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Thank you. I'll be back Yerrag. I need to rest a bit, my metaphorical feet are bleeding.
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Just for the sake of clarity, I’m not in the low A camp. I eat a normal “Peating” diet to which I’ve added dextrose, (in case anyone thought this was a factor).
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Here's a really good podcast without the solo artist performance in the first one I posted.
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Caution to this. It's very dangerous to indulge in big amounts of dextrose. I have seen people getting 200 blood sugar from 15 grams of it.
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@Razvan said in Glucose loading cures everything?:
Caution to this. It's very dangerous to indulge in big amounts of dextrose. I have seen people getting 200 blood sugar from 15 grams of it.
@Insomniac said in Glucose loading cures everything?:
I played around with about 200 grams but I ran out of glucose test strips. It brought up my heart rate but I didn't notice anything else.
I'm shocked 15 grams can do that much. Maybe they have a medical issue.
It probably depends gents, a lot on sodium (and chloride). And everything else thereafter.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232203/
I'm still getting used to walking with the idea there's legitimacy in what's going on here, for a certain kind of person with a certain kind of comorbidity. The question for me is whether they want to stay in that state, and how to get them out of it if they don't.
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@Razvan Dr Stephens says it's perfectly safe. He has hundreds of patients and high blood sugar levels have not been reported. He has literally nothing to gain by being dishonest. He doesn't even sell dextrose. (I asked him.)
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Could someone please tell Ms Holmes I'm sorry for being an obnoxious smartarse.
She may wish to keep me blocked. No problem. If she does could you remind her to tend to her salt appetite if, as, and, or when she may experience this kind of thing.
@Androsclerozat said in Glucose loading cures everything?:
I don't know. I've been dextrosed 300g day for 4 days and it changed me. I sleep well, I don't get sugar crashes anymore but man kills my appetite. I eat way less and I don't lose weight, maybe it's water weight from insulin spikes?
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@Androsclerozat said in Glucose loading cures everything?:
I don't know. I've been dextrosed 300g day for 4 days and it changed me. I sleep well, I don't get sugar crashes anymore but man kills my appetite. I eat way less and I don't lose weight, maybe it's water weight from insulin spikes?
I would say this would be expected
Especially if your cells are in a stressed stateEvan has had great results because he was eating (not sure for how long) a healthy amount of calories and or carbohydrates.
This is based on some physiology and some personal experience.
One act of obedience is better than one hundred sermons.
-DB
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@Peatful said in Glucose loading cures everything?:
Evan has had great results because he was eating (not sure for how long) a healthy amount of calories and or carbohydrates.
You're absolutely right. Like this isn't just about salt. But still... he gets it.
https://x.com/search?q=%40thortorrens salt&src=typed_query&f=live
I don't mind this guy he's got a sense of humour. It's probably the egos that make them scrap with each other from time to time.
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Oh wait there's two Evan's now...
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@Peatful I'm taking 200+ grams daily (a week in). I haven't needed a trip to the hospital yet.
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@S-Holmes said in Glucose loading cures everything?:
@Peatful I'm taking 200+ grams daily (a week in). I haven't needed a trip to the hospital yet.
Hey, this is voice recognition. Thanks for the update.
Yes, the way I did it I would not recommend which was going all in
Now my outcome was good, but the journey was indescribably rough,
but my body didn’t fail me and it knew what to do -
@Peatful How long did you take glucose?
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@S-Holmes said in Glucose loading cures everything?:
@Peatful How long did you take glucose?
I didn’t do that.
I just ate an abundance of simple carbohydrates, mostly in the form of sucrose for about a year.To not stress my adrenals, I was trying to take in that much sugar with a balanced amount of fats and proteins so my adrenals would not work over time trying to regulate my blood sugar
I was in extremely bad health mind you
Not hyperboleAgain, this is voice to text
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@Peatful Eating sucrose isn't the same as glucose therapy. Sucrose can definitely cause BS spikes. And I've eaten sucrose for years but continued to decline. Glucose therapy is definitely not to be confused with regular sugar in high amounts (which I won't do).
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Two interesting things to note:
One, I got a copy of Dr Stephens’s book and in it he suggests that if you are ready to increase your dose to do so by no more than 8grams a week. Then remain at that dose for the week before adding another 8grams.
Two, since adding the dextrose I am noticing I have something of a mildly unpleasant reaction to fruit. Perhaps this reaction was there and I wasn’t able to parse it out from the noise of my body’s condition? At any rate, I’ve tried it out a few times, and very definitely I get residue on my teeth and a slight inflammation of my gums when I eat fruit away from my dose of dextrose. This is crazy to me because I’ve been eating large volumes of fruit for almost 6 years, (not unreasonably large, but it’s been a staple in my diet). During the 6ish years I’ve been incorporating Peats work I’ve had transient issues with inflammation and weight gain, (granted I was underweight when I found Peat’s work).
I have experimented with starch, (always with saturated fat) and sucrose, and not experienced the same gritty residue on my teeth or accompanying gum sensitivity. Dextrose on the contrary soothes my gums and makes my teeth hard and shiny. Anyone care to venture a guess? I was thinking a 50mg daily round of penicillin VK perhaps. Would bacteria have any affinity for fructose over dextrose? I’ve only been on cynomel for about a month now, (I was one of those stubborn hold-outs who thought a pharmaceutical hormone couldn’t possibly be good for me, lol). Perhaps I just need some more time with thyroid before my immune system improves and I’m less susceptible to local infection, (which may be a simple explanation to this oral issue).
