Okay, so your experiment can be summarized as:
You spent years reading information, instead of cracking the organism's algorithm yourself, you wasted all that time trying to copy what looked like recommendations and failed, and now, after getting tired of your attempts and feelings, you have only the strength left to search for "miracle drugs" - but it turns out there are none!
I can only tell you that the solution to your problems definitely exists! If you have invested many years in reading information from Ray Peat and others, then you have an excellent foundation and you can absolutely do what it takes to crack the puzzle yourself. No one has provided us with the finished puzzle ready to use and you probably haven't realized it until today (If you say you've applied everything you've learned and still haven't been able to fix the system).
By the way, this brain valve is biological nonsense that the doctor invented to bridge his gap in understanding the organism.
The active thyroid hormone T3 is required to provide enough glucose to the brain
Inflammation, intracellular calcium, nitric oxide, and intracellular estrogen prevent proper cell function, including efficient utilization of glucose
Fructose with glucose as in fruits, honey, and white sugar is a powerful tool for repairing metabolism and the liver, but if the liver is too fatty - fructose can accelerate fat accumulation even more and the balance between glucose and fructose consumption needs to be found depending on the state of the system, such as the level of fat in the liver and the ability of the cells to accept and burn glucose - because excess sugars in relation to the body's ability to utilize it, leads to the same problems as excess fats.
Reduce inflammation, serotonin, nitric oxide, estrogen, PTH, cleanse the digestive system and fat from the liver, supplement thyroid hormones with great skill, combine strength training, body warming and red light, avoid an anti-metabolic, pro-inflammatory diet - good luck (this is of course just super general information)