@CrumblingCookie said in Glucose loading cures everything?:

@gentlepotato said:

I've been doing glucose daily since July and no doubt my intesties are healing, I'd even say healthy.

That's great! Can you tell us more about this, how and from what they are healing and how you notice significant differences? Or please refer to an earlier post of you in case I am struggling to remember.

What are your sources here?

-2c. glucose dieting is the worst for healing intestinal issues as, in total contrast, it inhibits HMGCS2 even significantly more instead of helping this much needed recovery pathway.
-2cc. going by this to me new info I really shot myself in the guts, metaphorically, by hoping for relief and recovery through glucose. Since my health issues start or end in the guts it now appears I've put the cart before the horse. Insert an array of swear words here. Damn!

I took up those info on glucose//butyrate effects from this 2019 study. It's in mice but there are references to findings in humans and mammals generally:
Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet

This one's not a bad review from 2010:
From the gut to the peripheral tissues: the multiple effects of butyrate. Interestingly, hepatocytes take up butyrate through a liver-specific organic anion transporter 7, OAT7 (SLC22A9), in exchange for sulfate-conjugated xenobiotics and steroid hormones (i.e. efflux of estron-sulphate or DHEA-S). Which should be "peaty", no?

There must be some wise and healthy way to reconcile or combine the whole SCFAs effects with those from glucose. Maybe by taking frequent "low" <60grs doses of glucose like you do for a full gastric/duodenal uptake without disturbing the metabolic homeostasis of lower GI parts. And take no glucose but exogenous butyrates in the evening/before the nighttime stretch in order to feed and induce ketogenic metabolism, circadian leukocyte functions and ISC renewal.
I now view the whole discussions about "sterile guts" and the microbiome in a newly simplified light: Ideally, the GI fermentation would provide a steady supply of SCFAs not only to the gut itself but with a surplus to the human organism as a whole, thereby increasing and maintaining resilience by complementing the energy requirements of the latter and relieving its otherwise dominating reliance on stress-induced ketosis and anaerobic glycolysis to span across times of carbohydrate/glucose fasting.

🤯

@CrumblingCookie said in Glucose loading cures everything?:

@S-Holmes
How much of the BHB salts do you take per day?

By what I've coped to read up on BHB:

1. it doesn't smell as butyric acid does. It can therefore be used as loose powder.
2. it shares many benefits with butyric acid, mostly the general HDAC-inhibition which is super super crucial for maintaining intestinal stem cell renewal to thwart lasting damages from chemical, toxic, irradation treatments.
   -2b. the removal of inhibitions for the mitochondrial enzyme hydroxymethylglutaryl CoA synthase HMGCS(2) is decisive for that stem cell renewal.
   -2c. glucose dieting is the worst for healing intestinal issues as, in total contrast, it inhibits HMGCS2 even significantly more instead of helping this much needed recovery pathway.
   -2cc. going by this to me new info I really shot myself in the guts, metaphorically, by hoping for relief and recovery through glucose. Since my health issues start or end in the guts it now appears I've put the cart before the horse. Insert an array of swear words here. Damn!
3. some intestinal bacteria can even use their β-hydroxybutyrate dehydrogenase to convert it to butyric acid.
   -3b. it's a substrate for the fragile lactobacilli to form beneficial biofilms (purportedly very rare) so they can maintain their colonisation and barrier assistance
4. inulin (prebiotic) converts mostly to butyrate instead of acetate or proprionate. So the L.reuteri yoghurt making benefits surely rely a lot on the generously added inulin as a distinctly L.-reuteri-independent treatment.

I'm going to buy potassium-BHB and eat that as high as my potassium requirements allow. I'll aim for 20g a day whereof it's 5g potassium.

Wow! That's great information! Why not use all of the beta hydroxybutyrate minerals (calcium, magnesium, and potassium)?

@gentlepotato

https://thyroidpharmacist.com/articles/candida-and-hashimotos-connection/

@S-Holmes said in Glucose loading cures everything?:

@gentlepotato Tbh, I didn't track calories, macros, or micros. We know high blood sugar can feed fungal infections. It's a conundrum for sure because humans AND fungi need sugar for fuel. Carb and sugar restriction is not an option. Ketogenic diet is not an option since it raises stress hormones, and also Ray said if we don't provide fuel for "candida" it will break down our own tissues to get what it needs. I took antibiotics for years in my mid teens, and in my early twenties developed an autoimmune disease. Did overuse of antibiotics set me up for lifelong fungal overgrowth? I don't know.

Hmmmm.

@gentlepotato Tbh, I didn't track calories, macros, or micros. We know high blood sugar can feed fungal infections. It's a conundrum for sure because humans AND fungi need sugar for fuel. Carb and sugar restriction is not an option. Ketogenic diet is not an option since it raises stress hormones, and also Ray said if we don't provide fuel for "candida" it will break down our own tissues to get what it needs. I took antibiotics for years in my mid teens, and in my early twenties developed an autoimmune disease. Did overuse of antibiotics set me up for lifelong fungal overgrowth? I don't know.

@gentlepotato I wonder how many of us who did high dose glucose therapy and had weight gain and other issues while on it have fungal overgrowth. As I mentioned before, I'm still using it but have added exogenous ketones for weight loss and have started antifungals (H202 drops, topical castor oil, undecylenic acid, proteolytic enzymes).

@CrumblingCookie I'm still on glucose, but not high doses. I can always tell when I need it. Also, still taking modified citrus pectin and acacia. I don't seem to have any ill effects from them.

In other news I've started taking calcium beta hydroxybutyrate, magnesium beta hydroxybutyrate and sodium beta hydroxybutyrate to lose weight. As I understand, these are exogenous ketones so they provide energy without spiking stress hormones like a ketogenic diet would. Would you give these thumbs up or thumbs down?

@CrumblingCookie said in Glucose loading cures everything?:

@S-Holmes said:

The next thing I'm going to try is higher dose vitamin D

Don't. It's a trap.

Oh no! Why? I took 50,000 IU's on Saturday, 40,000 on Sunday, 30,000 today, with plenty of magnesium and vit K. Feeling a lot better so far. I'll probably go on a winter maintenance dose of about 10,000 IU a day.

@gentlepotato said in Glucose loading cures everything?:

@S-Holmes sorry to hear you got covid again. One can take a long time to recover after it, so you might see a clearing after a while, but very wise to do extreme rest for now. I think it's smart to approach covid the way one would mono, so take it easy for at least three months. Hope you get better soon!

Do you ever test for EBV? It's one of the virus' that can reacivate after covid, and if it has you might benefit from some herbs.

I'm still just doing glucose, because I want to keep it simple, but if I am gonna add something at some point olive leaf extract is high of my list. Often mentioned for EBV.

I likely have EB or GB. I haven't been tested because what's the point? They're both autoimmune conditions and I'm already doing everything I know to do for CFS. The next thing I'm going to try is higher dose vitamin D, along with all the other things I'm already taking.

I really appreciate everyone's input. Doctors have no answers so I rely on my smart friends for information and assistance.

So friends. My husband and I got covid over Christmas (family member brought it with them) and true to form, I have long covid again. Husband is 95% well. My conclusion is that people with lifelong CFS/ME, even though mostly controlled, will be way more susceptible to complications than most. My post covid anxiety is back, and just as before, it peaks right at sundown. I'm able to control it using magnesium and Mexicola if I take them 10 or 15 minutes before the sun sets. If I forget, I go ahead and take them but will have to sit or lie down for a while until they take effect.

We're still using dextrose, but in small amounts. Again, my husband responds to it really well and I make sure his bottle of lemon/glucose water is full when he is in a stressful situation or has to do any public speaking. I feel like it helps me but I wouldn't say it has cured my chonic conditions.