Glucose loading cures everything?
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Yes, Mercola's daily dosing recommendation is absolutely a lot (c. 250-500grs/day).
However, I reckon it ought to be the most detrimental to teeth to drink that an ounce at a time (= 1/2-1 tbsp or c. 4-8 grs), or even 'sipping' it continuosly throughout the day!
Mercola's still worried about any insuline spikes, though, and for these reasons recommends such i.v.-style dosing. I don't think he has met with DS yet. Or maybe he has but treads carefully wrt what he presents since BG/insuline spikes are the first and decisive thought most people get scared of.I still find 2-hourly dosing much more reliably comfortable than longer periods. Although it's greatly convenient to have had enough dextrose to last 4-5hrs, such long times between servings do not always work or suffice IME.
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@Jaffe said in Glucose loading cures everything?:
@S-Holmes said in Glucose loading cures everything?:
Quick update. I'm still on 6 TBSPs of glucose 3 to 4 times a day. I've been taking my temperature again lately and am amazed. My afternoon temps are running 99° to 99.3°. I used to take thyroid (T3), maybe 10 years ago, and my temps were still in the dumpster. The thyroid didn't do much for me. So I've had an aha moment. In order for thyroid to work it must have enough glucose. (RP101), so the glucose therapy is restoring thyroid function. I have never restricted sugar, never done the keto diet, but apparently my high stress levels and PUFA's were enough to wreck my metabolism. Glucose to the rescue!
Ragweed been kicking out ass lol idk why I didn’t think to try this again
Not trying to divert this topic but if you have ragweed allergies, see the thread I posted about (my) allergies and ragweed:
https://bioenergetic.forum/topic/2889/black-sseed-for-asthma-and-allergy-conditions-it-works?_=1726706798350 -
Dr. Stephens knocked it out of the park at the health conference yesterday. It was an alt health event in my state attended mostly by parents of autistic kids. I've never seen so many emotional moms. He has given them hope.
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@S-Holmes Did he share anything specific there about cases where he has treated children with diagnoses such as autism?
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@jjk_learning said in Glucose loading cures everything?:
@S-Holmes Did he share anything specific there about cases where he has treated children with diagnoses such as autism?
Yes, but he also covers a lot of the same information in his videos on his website as well as in his books.
Once the video is uploaded I'll try and share a link. Q and A won't be included because it was held off stage in a smaller, more private area.
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@S-Holmes said in Glucose loading cures everything?:
@jjk_learning said in Glucose loading cures everything?:
@S-Holmes Did he share anything specific there about cases where he has treated children with diagnoses such as autism?
Yes, but he also covers a lot of the same information in his videos on his website as well as in his books.
Once the video is uploaded I'll try and share a link. Q and A won't be included because it was held off stage in a smaller, more private area.
Thank you! I'll be interested to see the talk if you end up able to share a link.
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@jjk_learning said in Glucose loading cures everything?:
@S-Holmes said in Glucose loading cures everything?:
@jjk_learning said in Glucose loading cures everything?:
@S-Holmes Did he share anything specific there about cases where he has treated children with diagnoses such as autism?
Yes, but he also covers a lot of the same information in his videos on his website as well as in his books.
Once the video is uploaded I'll try and share a link. Q and A won't be included because it was held off stage in a smaller, more private area.
Thank you! I'll be interested to see the talk if you end up able to share a link.
Have you watched the video available on his website?. It should be a lot of the same information. But I'll provide the link to the presentation he did last Saturday asap.
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Has anybody here longterm success with this protocol? I did yesterday 4 times a day one dextro energy ( 5g dextrose) just to see what happened? It reaches directly the brain and I get calm but after 30-60 minutes I get hypoglycemic response. Last week I did also what Ray mentioned in one of his videos 1 pound additional sugar in 3 days to reset the thyroid from stress. I did half a pound what it was really great more energy more calm and some effect on the thyroid where it was loosen up not so tight anymore in the thyroid area. If you hear Dr. Stephens Videos u here like nearly everybody has instant relief from his protocol I think this doesnt match with the reviews here and on RPF
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@S-Holmes Which video on his website? Right now I'm not seeing anything at https://www.peakneuropsych.com/ but I don't know if that's the site you are referencing.
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@Mr-X said in Glucose loading cures everything?:
Has anybody here longterm success with this protocol? I did yesterday 4 times a day one dextro energy ( 5g dextrose) just to see what happened? It reaches directly the brain and I get calm but after 30-60 minutes I get hypoglycemic response. Last week I did also what Ray mentioned in one of his videos 1 pound additional sugar in 3 days to reset the thyroid from stress. I did half a pound what it was really great more energy more calm and some effect on the thyroid where it was loosen up not so tight anymore in the thyroid area. If you hear Dr. Stephens Videos u here like nearly everybody has instant relief from his protocol I think this doesnt match with the reviews here and on RPF
I'm still trying the protocol; approximately 3 months in. So I can't say much one way or the other.
However, I agree with you. From Dr. Stephens' videos, it sounded like basically instant relief across the board, whereas that is not what we are seeing in these forums. I've seen enough positive reports to think maybe there's something to this protocol, but I've seen enough reports conflicting with Stephens' representation to question its veracity.
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@jjk_learning did u get than instant relief after a few days? Or are you different person after these 3 months are there things which are better than before?
I dont know if hes right with his assumptions why it is working, I think we all agree that our brains needs a huge amount of sugar to function. Many dont saw the relief from a high sugar diet from peat many dont saw a relief from the glucose protocol. Many took care also of the cofactors b1, potassium and so on but also dont saw a relief.
I think glucose + t3 could be a good combo
My most memorable bioenergetic moment in my life was when I transferred from t4 only and added additional t3. I was lying on my couch and my eyes was falling backwards such a chill mode calm happy. Like the first time energy in my brain for years, but then next days i get huge adrenaline spikes but thats another story
Also i liked the explanation from @gentlepotato
in this thread would like to know how is it going with his protocol -
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I'm also 3 months on the protocol. My husband too. He is doing really well and I have good and bad days, but remember Dr. Stephens says it takes 4 to 12 months for your body to heal. Older people with more advanced pathology may take longer. It seems people are trying it for a day or a week, decide it doesn't work and just stop. I'm giving it the full test.
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Hi everyone,
Thanks for sharing! I've been reading, but not had the energy to post. I've had similar thoughts and questions, and also had the impression that people saw relief right away. That's not happened for me yet.
@S.Holmes, so he says at least 4 months before you may see some results? I had missed that. I am planning to stick with it 6-9 months, as that's what he suggested. In the video I've seen where he talks about it, I think he said 9 months for people older than 70?
I started at the beginning of July. I had some increase in energy the first month, and then - I think - my immune system started waking up. I had two 36 hour very obvious immune responses, and then a bunch of smaller ones, lasting a few hours. Whatever it's fighting in the chest it's not won yet - I also sense it's fighting something in the brain.
I have a wonderful GP and have benefited from her perspective on a regular basis; it's easy to focus on what isn't better, but there are also many positive changes - and if this is the immune system waking up, I believe that is major.
I'm trying to be patient and think that if this was an active infection and my immune system was fighting something, it may take weeks or even months to fight off a pathogen. From what I understand the Itaconate shunt is activated by the innate immune system (which we are born with), and when the adaptive immune system turns on it's switched "off" - and that the issues many of us have is because the adaptive immune system never takes over, so the Itaconate shunt continues.
I have much more brain fog than I did in July, and didn't have the capacity now to double check if I understand it correctly, but if anyone wants to and have the capacity Rob Phair talks about this in this video: [https://youtu.be/PCnkkLlyVMk?si=Qqnjpp1vWus6N4Fa](link url); chapters Krebs cycle and Consequences, and perhaps more.
That leaves room for reactivation of viruses, from what I can gather, and that's certainly been the case for me. I'm hopeful that what's happening now is good long term.
If this is the immune system fighting something that would explain why my cycle is affected negatively. I'm curious if anyone has a similar experience. Anyone with a cycle, who's been doing this for 3 months or more?
I forgot to mention I've switched to 3x4 and 2 tbsp before bedtime, totalling 14 a day. The two times I've tried 3 at night I get a brutal stomach ache, which I don't do during the day, so I'm sticking with 2. Every hour worked well for me at the beginning, I think I store glucose poorly, so it made sense. Then my gut feeling said to switch a couple of weeks ago.
Overall lots of my markers are positive, and I'm not having many issues with the protocol. But I'm quite exhausted and feel introverted. I'm taking it as a sign to not do much, and hope this will allow my body to do what it needs to.
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@gentlepotato said in Glucose loading cures everything?:
Hi everyone,
Thanks for sharing! I've been reading, but not had the energy to post. I've had similar thoughts and questions, and also had the impression that people saw relief right away. That's not happened for me yet.
@S.Holmes, so he says at least 4 months before you may see some results? I had missed that. I am planning to stick with it 6-9 months, as that's what he suggested. In the video I've seen where he talks about it, I think he said 9 months for people older than 70?
I started at the beginning of July. I had some increase in energy the first month, and then - I think - my immune system started waking up. I had two 36 hour very obvious immune responses, and then a bunch of smaller ones, lasting a few hours. Whatever it's fighting in the chest it's not won yet - I also sense it's fighting something in the brain.
I have a wonderful GP and have benefited from her perspective on a regular basis; it's easy to focus on what isn't better, but there are also many positive changes - and if this is the immune system waking up, I believe that is major.
I'm trying to be patient and think that if this was an active infection and my immune system was fighting something, it may take weeks or even months to fight off a pathogen. From what I understand the Itaconate shunt is activated by the innate immune system (which we are born with), and when the adaptive immune system turns on it's switched "off" - and that the issues many of us have is because the adaptive immune system never takes over, so the Itaconate shunt continues.
I have much more brain fog than I did in July, and didn't have the capacity now to double check if I understand it correctly, but if anyone wants to and have the capacity Rob Phair talks about this in this video: [https://youtu.be/PCnkkLlyVMk?si=Qqnjpp1vWus6N4Fa](link url); chapters Krebs cycle and Consequences, and perhaps more.
That leaves room for reactivation of viruses, from what I can gather, and that's certainly been the case for me. I'm hopeful that what's happening now is good long term.
If this is the immune system fighting something that would explain why my cycle is affected negatively. I'm curious if anyone has a similar experience. Anyone with a cycle, who's been doing this for 3 months or more?
I forgot to mention I've switched to 3x4 and 2 tbsp before bedtime, totalling 14 a day. The two times I've tried 3 at night I get a brutal stomach ache, which I don't do during the day, so I'm sticking with 2. Every hour worked well for me at the beginning, I think I store glucose poorly, so it made sense. Then my gut feeling said to switch a couple of weeks ago.
Overall lots of my markers are positive, and I'm not having many issues with the protocol. But I'm quite exhausted and feel introverted. I'm taking it as a sign to not do much, and hope this will allow my body to do what it needs to.
Thank you for your feedback! I had some viral flare ups about 1 month in. One was particularly painful (shingles), but none in weeks. I still have some issues, headaches, allergies, but many symptoms came and went and haven't come back. I also think supplements can be an issue. Dr Stephens says when the macros (glucose being the primary one) are being met, you may find the micros can be reduced or eliminated. I think that's because digestion is improved and we start getting more of them from food. That seems to have happened with me.
Fatigue can be an issue, but the body uses a lot of energy when it's healing. I find I do need a midday rest.
I'm fascinated with the itaconate shunt theory, but I don't know if it has been fully proven yet. I looked for research updates a few weeks ago and didn't find any.
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I've thought the same about deficiencies becoming less of a problem when the system works better. Not only because of digestion, but if you have multiple shunts you'll have imbalances and likely deficiencies, and when that's avoided micro nutrients are not used up as fast and can be used for the intended jobs.
I'm fascinated with the itaconate shunt theory, but I don't know if it has been fully proven yet.
Do that mean if Itaconate Shunt hypothesis specifically for ME/CFS has been fully proven? No one is suggesting it has been fully proven, it's still a hypothesis. That said, lots of fairly established truths in medicine are hypothesis and not fully proven. There's even been very established truths in medicine that were never researched, until a hypothesis and new research challenged the old approach.
I enjoy hypothesis because they're more see through. They are works in progress and in this case the hypothesis is explained in great detail, which means we can discuss the details! Is there anything specific about the hypothesis that doesn't resonate for you?
I looked for research updates a few weeks ago and didn't find any.
The ME/CFS researchers I've linked to are leading researchers on the hypothesis and the hypothesis is not the only thing they're working on, but I assume they (and other ME/CFS researchers) are basing their other research (creating a biomarker and/or treatments that work) on that hypothesis. I don't think you'll find research on the specific hypothesis on a regular basis, it may take years between every time they present new findings.
Thorough research takes a lot of time, but in this case it's also in large part because it's so hard to get funding for ME/CFS studies, unfortunately. Like I've said before I think that's an issue for medicine overall, because if you understand ME/CFS you may understand a lot of other illnesses. I also think the overall disregard for ME/CFS means that researchers in other fields aren't curious about this important research, and therefore it won't spread to other fields even if it would be applicable. It's incredibly sad to see the ramifications of the gasligthing and misinformation about the diagnosis.
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@gentlepotato said in Glucose loading cures everything?:
I've thought the same about deficiencies becoming less of a problem when the system works better. Not only because of digestion, but if you have multiple shunts you'll have imbalances and likely deficiencies, and when that's avoided micro nutrients are not used up as fast and can be used for the intended jobs.
I'm fascinated with the itaconate shunt theory, but I don't know if it has been fully proven yet.
Do that mean if Itaconate Shunt hypothesis specifically for ME/CFS has been fully proven? No one is suggesting it has been fully proven, it's still a hypothesis. That said, lots of fairly established truths in medicine are hypothesis and not fully proven. There's even been very established truths in medicine that were never researched, until a hypothesis and new research challenged the old approach.
I enjoy hypothesis because they're more see through. They are works in progress and in this case the hypothesis is explained in great detail, which means we can discuss the details! Is there anything specific about the hypothesis that doesn't resonate for you?
I looked for research updates a few weeks ago and didn't find any.
The ME/CFS researchers I've linked to are leading researchers on the hypothesis and the hypothesis is not the only thing they're working on, but I assume they (and other ME/CFS researchers) are basing their other research (creating a biomarker and/or treatments that work) on that hypothesis. I don't think you'll find research on the specific hypothesis on a regular basis, it may take years between every time they present new findings.
Thorough research takes a lot of time, but in this case it's also in large part because it's so hard to get funding for ME/CFS studies, unfortunately. Like I've said before I think that's an issue for medicine overall, because if you understand ME/CFS you may understand a lot of other illnesses. I also think the overall disregard for ME/CFS means that researchers in other fields aren't curious about this important research, and therefore it won't spread to other fields even if it would be applicable. It's incredibly sad to see the ramifications of the gasligthing and misinformation about the diagnosis.
The itaconate shunt is certainly a plausible explanation for glucose limiting effects following injury or trauma. Is it the only explanation? I don't know. All I know is that glucose therapy seems to be working for many. Maybe it reverses the shunt? If you find more information about this, I'm interested.
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can you provide somewhere with a summary of glucose loading protocol and any supportive cites? I can't watch a 1 or 2 hour video generally. I am grateful for your help.
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@Ecstatic_Hamster said in Glucose loading cures everything?:
can you provide somewhere with a summary of glucose loading protocol and any supportive cites? I can't watch a 1 or 2 hour video generally. I am grateful for your help.
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@Peatful said in Glucose loading cures everything?:
@Insomniac said in Glucose loading cures everything?:
@Peatful Exactly. Ray Peat doesn't even come up in the conversation. They've scrubbed him.
They never understood him.
Is it because the HPA axis becomes more sensitive with every trauma, and more ready to switch into sympathetic mode, stress cascade and ultimately more fat metabolism, inhibiting glucose metabolism. Maybe flooding the system with glucose stops the stress hormones from needing to be activated and slowly over time this makes the HPA axis less reactive through neuroplastic pathways being desensitised.
