Glucose loading cures everything?
-
@Ecstatic_Hamster said in Glucose loading cures everything?:
I think another mechanism that may be in play here, with Dr. Stephens' system, is suppression of hyperglycolysis. Which produces only pyruvate and a little CO2 and energy, and burdens the brain. The brain responds by diminishing consumption of glucose and switching partially to using glutamine. This is EXACTLY what happens with Warburg's "cancer field" idea.
I proposed this idea to ChatGPT
Potential Mechanisms for Glucose Loading to Work:
Potential Mechanisms for Glucose Loading to Work:• Enhancing Mitochondrial Function: By providing ample glucose,
you could support mitochondrial oxidative metabolism by ensuring a
steady supply of pyruvate to the Krebs cycle, increasing electron
transport chain activity and ATP production.• Reducing Lactate Buildup: Slowing down glycolysis might reduce the accumulation of
lactate (which occurs when pyruvate is converted to lactate in
anaerobic glycolysis), which is often a hallmark of hyperglycolysis
in conditions like cancer or impaired mitochondrial function.• Rebalancing ATP Production: Encouraging ox-phos would lead to
more efficient ATP production (since oxidative phosphorylation
produces significantly more ATP per glucose molecule than
glycolysis) and may reduce the compensatory need for rapid
glycolysis in states of high energy demand.Caveats:
• Cancer Cells and Adaptation: In cancer, cells have adapted to
rely on glycolysis due to changes in mitochondrial function or other
oncogenic signaling. Glucose loading alone may not be enough to
reverse these metabolic shifts. However, in non-cancerous
hyperglycolytic states, it could potentially restore metabolic
balance.• Tumor Environment: The tumor microenvironment, which
often includes hypoxia (low oxygen), favors glycolysis. Simply
providing more glucose may not necessarily shift cells back to
ox-phos in such environments without other interventions (e.g.,
improving oxygen availability or mitochondrial function).Conclusion:
While it is speculative, the concept of glucose loading could
theoretically help regulate metabolism by reducing hyperglycolysis and
encouraging oxidative phosphorylation, leading to increased CO₂
production and more efficient energy use. This could be beneficial in
certain cases of metabolic dysregulation, though in cancer cells, their
preference for glycolysis may make this strategy more complex. Further
research would be needed to confirm whether this approach is effective
across different conditions where hyperglycolysis occurs.🤯
So how does this (below) fit into this process?
"Several metabolic pathways for the supply of adenosine triphosphate (ATP) have been proposed; however, the major source of reducing power for ADP in cancer remains unclear. Although glycolysis is the source of ATP in tumors according to the Warburg effect, ATP levels do not differ between cancer cells grown in the presence and absence of glucose. Several theories have been proposed to explain the supply of ATP in cancer, including metabolic reprograming in the tumor microenvironment. However, these theories are based on the production of ATP by the TCA-OxPhos pathway, which is inconsistent with the Warburg effect. We found that blocking fatty acid oxidation (FAO) in the presence of glucose significantly decreased ATP production in various cancer cells. This suggests that cancer cells depend on fatty acids to produce ATP through FAO instead of glycolysis."
-
@idealabsrat thanks!
@Ecstatic_Hamster How does that theory differ from the Itaconate shunt hypothesis? Seems to be very similar.
-
Maybe someone can make this make sense. Is it sugar or fat that feeds cancer?
-
its absolutely insane that some here take up to 320grams of dextrose per day. And everybody is asking what can I do for my blood sugar crashes
is here somebody who did this protocol for several months and is now completely off glucose? I think after months of glucose loading you will go into hypoglycemic hell and youre in a worser state than before the protocol. -
@marmalade_cat said in Glucose loading cures everything?:
@Lena said in Glucose loading cures everything?:
I have been reading here for some time, and just registered to write here. I've had dextrose as my main source of energy for 2,5 years, because I don't tolerate enough of any other carbs.
This summer I learned about the dextrose protocol and tried it. I got terrible blood sugar crashes.
Now I have found what works for me. I take one Tbsp at a time, and then I wait a few minutes before I take another Tbsp. Lately I've been taking 7 Tbsp during 30 minutes 3 times a day, before breakfast, lunch and dinner. I don't get blood sugar crashes now.Thanks @Lena for sharing. That's so interesting.
As someone who has also experienced extreme blood sugar crashes on the glucose protocol, I'm curious to know more:- when you say you take 1 tablespoon at a time, I'm assuming you dissolve in water? I'm curious how much water/liquid per tablespoon?
- sorry for being pedantic, what is a "few" minutes, between tablespoons?
- what does your meals consist of? Macros and food types?
- has the volume of food changed on the dextrose protocol? I have found if I don't eat enough food with the Dextrose I experience hypo glycaemia.
- do you mind sharing age. I'm assuming you're female?
Thanks in advance!
I put 1 Tbsp in 80-100 ml water and drink immediately, stirring around while drinking or drinking through a straw. I prefer to not let it dissolve, both because I don't like the taste and because I get tartar on my teeth. I think it gets more sticky when it has dissolved.
Usually I wait 5 minutes between doses, but if I feel that I need it and tolerate it I sometimes wait only two minutes. If I feel that I have very high stress level I tolerate it much better. How well I tolerate it also depends on how much fat I have eaten. I tolerate it the best in the morning, before breakfast.
I eat what I for the moment can tolerate... Usually I add 2 Tbsp of olive oil to every meal, and lately I have started to add a little (less than a Tbsp) butter too. I don't tolerate starch, so not much carbs. Sometimes I take dextrose with my meals, but that causes greater risk I get reaction to the meal, so I try to avoid it. I eat meat, fish or some vegetarian protein like tofu or some protein powder that I tolerate. And some veggies.
When I tried the "real" dextrose protocol my appetite lessened so I couldn't eat as much, but with the dosages I take now I don't think so. I don't remember how it was before starting with dextrose, 2,5 years ago.
If I skip the olive oil I feel that I'm out of energy after maybe 2 hours.Yes, I'm female, 52 years.
-
I have tried to spread it out during the day, like 1 Tbsp every hour. For me that doesn't work. It can cause a flare up of candida that I don't get if I take a large dose within 30 minutes. And I also feel that I get unstable energy. I get more long lasting energy if I take like 7 Tbsp within 30 minutes, and then enough olive oil with food. As long as I have well filled glycogen storage I can get energy from olive oil.
-
@Mr-X said in Glucose loading cures everything?:
its absolutely insane that some here take up to 320grams of dextrose per day. And everybody is asking what can I do for my blood sugar crashes
is here somebody who did this protocol for several months and is now completely off glucose? I think after months of glucose loading you will go into hypoglycemic hell and youre in a worser state than before the protocol.I think most of us in this thread doing the protocol haven't completed it yet. 3.5 months seems to be the longest anyone has been on glucose. I have months to go, and have had many symptoms come and go. The best indicator for me is my temperature. It's doing well, even first thing in the morning, before food. My husband's temperature has responded the same. If, as Dr. Broda Barnes discovered, temperature indicates thyroid health, we are doing great. How will we do when we stop glucose loading? I'll find out in a few months.
-
@Mr-X said in Glucose loading cures everything?:
its absolutely insane that some here take up to 320grams of dextrose per day. And everybody is asking what can I do for my blood sugar crashes
is here somebody who did this protocol for several months and is now completely off glucose? I think after months of glucose loading you will go into hypoglycemic hell and youre in a worser state than before the protocol.I'm one of the people who have blood sugar crashes, and I only take 144 grams a day. I've had more crashed while taking high doses at a time, rather than 1 tbsp every hour. Going back to 1 tbsp hasn't fully solved it yet though. And I think that's one of the tricky things about glucose, that sometimes and in some forms it lowers BG, but it can also increase BG. People react differently too.
I used a continuous glucose monitor for two weeks, and I would say I am over average good at making sense of patterns, but I was never able to make sense of the patterns of how I was responding to taking glucose, or of blood sugar levels. It's not the first protocol that's tricky to navigate though, so I'm not too worried about it. It doesn't make me think the protocol isn't working.
You asked a while back about outlining symptoms etc, and I didn't have the spoons to respond. I started at the beginning of July, so nearly at 3,5 months. My best metaphor for what is going on is that for years it's felt like I'm in the fight scene in an action movie, only my car won't start. The "bad guys" (fuel demands of all kinds, normal day to day stuff, but also reactivation of viruses etc) is "coming", and my body has not been able to fight any of it off. It's been a constant fight I have not been winning.
Now I'm still in the fight scene, so it's very intense at times, but the car is working. I've still got symptoms, but the body appears to successfully fight pathogens. However I think the glucose might fuel viruses etc as well, so I've got a lot of stuff reactivating.
I have probably had low grade infection many places in the body for years, including my brain. With no immune reaction pathogens probably just bob around and make a little mess all the time. It hasn't had much to fight, it's just taken over. Now the immune system is fighting back, and with more glucose the viruses also have more energy. For example:
First (two months ago) shingles tried to break out in the nerve pathway it has infected before, the pathways that goes to the thumb - I had flu like symptoms for 36 hours, but I didn't have a rash, and then some pain for a few days after. Then a couple of weeks ago I had a similar pain in my head and rash under my eye appeared, which the body fought off quickly. The rash disappeared, but then the pain was back in my thumb, and then the rash reappeared under my eye. Now it's gone down again, but I still have some pain. However none of it has been as painful as when the virus broke out properly, not the rash and not the nerve pain.
The body is still working on fighting off the infection, and I think that also means it is healing stuff in the brain that it hasn't been able to heal before.
I think the immune responses are a very, very good sign, and that it can be considered a win in terms of the the Itaconate shunt hypothesis for ME/CFS (separate from my hypothesis for why glucose may work).
I use other markers to see if it's getting better overall. Many of them are still not super consistent, so I don't feel 100% certain it's working, and I'm very unsure how much better it can make me. But there are enough good signs. Some of the "small" good signs are that my digestion is working consistently better, even with my sleep being very disrupted. Despite being under the weather for two months now my cycle is overall healthier.
-
@gentlepotato so would you say you feel better. Is libido better. Is sleeping better. Is brain fog better. Thank you for your helpful account.
-
@gentlepotato said in Glucose loading cures everything?:
@Mr-X said in Glucose loading cures everything?:
its absolutely insane that some here take up to 320grams of dextrose per day. And everybody is asking what can I do for my blood sugar crashes
is here somebody who did this protocol for several months and is now completely off glucose? I think after months of glucose loading you will go into hypoglycemic hell and youre in a worser state than before the protocol.I'm one of the people who have blood sugar crashes, and I only take 144 grams a day. I've had more crashed while taking high doses at a time, rather than 1 tbsp every hour. Going back to 1 tbsp hasn't fully solved it yet though. And I think that's one of the tricky things about glucose, that sometimes and in some forms it lowers BG, but it can also increase BG. People react differently too.
I used a continuous glucose monitor for two weeks, and I would say I am over average good at making sense of patterns, but I was never able to make sense of the patterns of how I was responding to taking glucose, or of blood sugar levels. It's not the first protocol that's tricky to navigate though, so I'm not too worried about it. It doesn't make me think the protocol isn't working.
You asked a while back about outlining symptoms etc, and I didn't have the spoons to respond. I started at the beginning of July, so nearly at 3,5 months. My best metaphor for what is going on is that for years it's felt like I'm in the fight scene in an action movie, only my car won't start. The "bad guys" (fuel demands of all kinds, normal day to day stuff, but also reactivation of viruses etc) is "coming", and my body has not been able to fight any of it off. It's been a constant fight I have not been winning.
Now I'm still in the fight scene, so it's very intense at times, but the car is working. I've still got symptoms, but the body appears to successfully fight pathogens. However I think the glucose might fuel viruses etc as well, so I've got a lot of stuff reactivating.
I have probably had low grade infection many places in the body for years, including my brain. With no immune reaction pathogens probably just bob around and make a little mess all the time. It hasn't had much to fight, it's just taken over. Now the immune system is fighting back, and with more glucose the viruses also have more energy. For example:
First (two months ago) shingles tried to break out in the nerve pathway it has infected before, the pathways that goes to the thumb - I had flu like symptoms for 36 hours, but I didn't have a rash, and then some pain for a few days after. Then a couple of weeks ago I had a similar pain in my head and rash under my eye appeared, which the body fought off quickly. The rash disappeared, but then the pain was back in my thumb, and then the rash reappeared under my eye. Now it's gone down again, but I still have some pain. However none of it has been as painful as when the virus broke out properly, not the rash and not the nerve pain.
The body is still working on fighting off the infection, and I think that also means it is healing stuff in the brain that it hasn't been able to heal before.
I think the immune responses are a very, very good sign, and that it can be considered a win in terms of the the Itaconate shunt hypothesis for ME/CFS (separate from my hypothesis for why glucose may work).
I use other markers to see if it's getting better overall. Many of them are still not super consistent, so I don't feel 100% certain it's working, and I'm very unsure how much better it can make me. But there are enough good signs. Some of the "small" good signs are that my digestion is working consistently better, even with my sleep being very disrupted. Despite being under the weather for two months now my cycle is overall healthier.
This sounds so similar to my own experience with glucose. I remember that we both had reactivation of shingles around the same time, and both began taking glucose 3.5 months ago.
How are your temperatures and pulse? Mine are still doing well, consistently, but I've hit another rough patch. I sometimes wonder if I may have low grade fever. My morning temp seems high lately (98.9). I had constant "fever" and night sweats in my early 30's when I was diagnosed with an autoimmune disease, but after working with a homeopath and getting H202 IV's the fever and night sweats ended. Maybe I'm retracing those symptoms now. Hopefully this too shall pass, like the others.
-
@Ecstatic_Hamster said in Glucose loading cures everything?:
@gentlepotato so would you say you feel better. Is libido better. Is sleeping better. Is brain fog better. Thank you for your helpful account.
I would say it's intense in a different, hopefully more healing way than before.
I've eaten PM for 3 1/2 years and I would say it's helped a lot of things. All my markers (apart from the fatigue itself) were already so much better; it's night and day. Digestion is the only marker that wasn't consistently better already, and that got a lot better in July, and has stayed better.
I did see some more healing from glucose in July, even more positive changes in circadian rhythm, sleep, brain fog, and that's not as prominent anymore, but I chalk it down to having immun responses nearly back to back for two months. I'm still seeing benefits, and I'm very happy with the results everything considered.
@S-Holmes said in Glucose loading cures everything?:
This sounds so similar to my own experience with glucose. I remember that we both had reactivation of shingles around the same time, and both began taking glucose 3.5 months ago.
How are your temperatures and pulse? Mine are still doing well, consistently, but I've hit another rough patch. I sometimes wonder if I may have low grade fever. My morning temp seems high lately (98.9). I had constant "fever" and night sweats in my early 30's when I was diagnosed with an autoimmune disease, but after working with a homeopath and getting H202 IV's the fever and night sweats ended. Maybe I'm retracing those symptoms now. Hopefully this too shall pass, like the others.
Is your pulse and temperature doing well even when you're in a rough patch? My pulse has mostly been very stable and good since starting PM. Temperature also got better with, but has continued to be a little low, and it still is.
I stopped having fevers at some point after my ME got triggered, but have had fever/flu like symptoms many times. People can go both ways, but it's not uncommon to have a much lower temperature with ME. (I know of someone who had sepsis without breaking a fever, and likely just survived because they knew to go to the hospital based on other symptoms). I've tended towards too cold, but I'm very close to "normal" now. I'm sort of hoping for a real fever at some point, but if a slower immune response is what my body prefers I trust it knows best.
-
@gentlepotato Yes, temp, pulse, oxygen saturation, BP have all improved on glucose. I think for some of us healing just isn't going to feel great.
-
@S-Holmes said in Glucose loading cures everything?:
@gentlepotato Yes, temp, pulse, oxygen saturation, BP have all improved on glucose. I think for some of us healing just isn't going to feel great.
Definitely, not necessarily something that feels great, and the tricky thing really is to decipher what is just a part of healing and what are signals from the body that we need to tweak something. We might not even find the answers, but maybe sharing along the way at least will make it easier for those who try this after us.
-
@gentlepotato said in Glucose loading cures everything?:
@S-Holmes said in Glucose loading cures everything?:
@gentlepotato Yes, temp, pulse, oxygen saturation, BP have all improved on glucose. I think for some of us healing just isn't going to feel great.
Definitely, not necessarily something that feels great, and the tricky thing really is to decipher what is just a part of healing and what are signals from the body that we need to tweak something. We might not even find the answers, but maybe sharing along the way at least will make it easier for those who try this after us.
Case in point. One of my old symptoms is hemorrhaging. I could bleed for months, then do some "tweaking" and it would stop. I hadn't bled in over a year. But then last week, the floodgates opened. It was worse than ever. I told my nurse daughter, and her answer, as always, was for me to go see a doctor. But just as suddenly as it started, it stopped...not a drop. All of my retracing on glucose has been like this. It comes on suddenly and doesn't last long. One interesting observation about this is I would aways feel better while having the bleeding episodes. It made me wonder if our intelligent bodies know things, like for instance that I may have too much stored iron, and it finds a way to deal with it.
So many things to discover and contemplate on this healing journey.
-
Just an update on my experience using glucose. In the last few days I have upped my intake to 360 g spread throughout the day and the two main things I have noticed is that my adrenaline has gone down, but My fuzzy headaches have Increased. I think this might just be my body adjusting to the change. It would make sense that if my adrenaline was going down, I may have less energy in the interim, as actually less sugar is available to my brain.i.e Less sugar being liberated by the adrenaline.
Last night as an experiment, I drank 120 g of dextrose in milk, And I had amazing dreams all night. When I woke I normally have palpitations, these weren’t there. I wonder if the milk helped buff the glucose to last longer throughout the night? Also, I should mention at the same time I used a bit of Progest-e Which helps lower the insulin reaction to glucose. (Ref michael platt, adrenaline dominance)
I think, if you spend a lot of the day like I do running on stress hormones, it can feel like you take Step backwards when you run on glucose metabolism without stress hormones, But I hope this will come good as my body re learns How to use glucose properly.
-
@josh great to hear and thank you for continuing to comment on your journey. It helps me and I'm sure all of us.
-
What is PM and ME dieting? Thanks
-
@Ecstatic_Hamster said in Glucose loading cures everything?:
What is PM and ME dieting? Thanks
I think you're referring to what I wrote? PM is pro metabolic, and ME is my diagnosis, often called ME/CFS internationally, but it's often just called ME in my country so I forgot to add the /CFS.
-
@gentlepotato said in Glucose loading cures everything?:
@Ecstatic_Hamster said in Glucose loading cures everything?:
What is PM and ME dieting? Thanks
I think you're referring to what I wrote? PM is pro metabolic, and ME is my diagnosis, often called ME/CFS internationally, but it's often just called ME in my country so I forgot to add the /CFS.
Thank you.
-
im thinking of trying this glucose loading thing but just a pre and intra and post workout shake for weightlifting / sprinting / etc workouts . some days I eat like 200g of honey in one sitting, it's like I can't get enough. I wonder if pure glucose will be better?
