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Removing IL-11 extends life by over 20%

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  • M
    Mauritio
    last edited by Mauritio Jul 20, 2024, 8:25 PM Jul 20, 2024, 8:24 PM

    Deleting the IL-11 gene in mice increases life span by over 20% .
    Once again, showing that inflammation is at the root of aging. Not just aging, but disease in general ,since the mice were a lot healthier in many other ways, too.

    https://www.sciencedaily.com/releases/2024/07/240717120907.htm

    Dare to think.

    My X:
    x.com/Metabolicmonstr

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    • D
      DavidPS
      last edited by DavidPS Jul 26, 2024, 10:45 PM Jul 26, 2024, 10:44 PM

      Thanks for the heads up on IL-11. It seems that it not only extends lifespan by almost 25% but it also extends healthspan. There are anumber of ways to increase lifespan by 10% but 25% is much less common.
      807c445b-cc68-44cf-9bc6-3ccd7974578b-image.png

      IL-11 inhibition is similar in effect to rapamycin (Sirolimus).

      Inhibition of IL-11 signalling extends mammalian healthspan and lifespan

      You can catch more flies with honey than vinegar. 👀
      ☂️

      M 1 Reply Last reply Jul 27, 2024, 3:00 PM Reply Quote 0
      • M
        Mauritio @DavidPS
        last edited by Jul 27, 2024, 3:00 PM

        @DavidPS said in Removing IL-11 extends life by over 20%:

        Thanks for the heads up on IL-11. It seems that it not only extends lifespan by almost 25% but it also extends healthspan. There are anumber of ways to increase lifespan by 10% but 25% is much less common.
        807c445b-cc68-44cf-9bc6-3ccd7974578b-image.png

        IL-11 inhibition is similar in effect to rapamycin (Sirolimus).

        Inhibition of IL-11 signalling extends mammalian healthspan and lifespan

        Thanks I was looking for something that can reduce IL11 . So rapamycins anti-aging effects might not (only) be due to the mTOR inhibition.

        25% is good which is similar to ergothioneine,but it is still far from the 40% that methionine and cysteine restriction produced.

        Dare to think.

        My X:
        x.com/Metabolicmonstr

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        • D
          DavidPS
          last edited by Aug 5, 2024, 3:42 PM

          5 Supplements To Inhibit IL-11 (animal studies)
          Youtube Video

          One of the comments on YouTube:

          Thx Richard for this interesting presentation.Actually it's not necessarily the curcumin but the other ingredients in turmeric that are responsible for the inhibition of IL-11.
          So the whole food is always more potent than any supplement. By the way piperlongumine also inhibits IL-11. I take them every day in my coffee and in meals combined with olive oil ,black pepper and ginger.

          You can catch more flies with honey than vinegar. 👀
          ☂️

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