Daily Vinegar Ingestion Improves Depression and Enhances Niacin Metabolism in Overweight Adults: A Randomized Controlled Trial
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This study gave the participants 4 tablespoons of red wine vinegar daily for 4 weeks (4 x 4) and they had a 'significant' improvement in depression scores. Metabolomics analyses revealed increased nicotinamide concentrations and upregulation of the NAD+ salvage pathway for VIN participants compared to controls, metabolic alterations previously linked to improved mood. Thus, daily vinegar ingestion over four weeks improved self-reported depression symptomology in healthy overweight adults, and enhancements in niacin metabolism may factor into this improvement.
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In a 2020 study with mice, ACV attenuated LPS-induced anxiety- and depressive-like behaviors in mice. This effect is likely due to inhibition of oxidative stress and proinflammatory cytokines.
Apple cider vinegar attenuates lipopolysaccharide-induced
neurobehavioral deficits in mice -
Methylene blue also helps with depression.
A controlled trial of methylene blue in severe depressive illness
Methylene blue at a dose of 15 mg/day appears to be a potent antidepressant, and further clinical evaluation is essential.
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@otto - Thanks for the study. There is more than one way to skin a cat (deal with depression).
Pharmaceutical SSRIs, which increase the 'happiness hormone', have their issues. Especially when a person stops taking them. At one time there was talk about many of the mass shootings were done by people who recently stopped their SSRIs. Now it seems that the medical privacy of the deceased shooter is more important than the discovering the root cause.
SSRI drugs, not depression, destroy empathy
http://haidut.me/?p=1053
