Is Cialis/Tadalafil Harmful?
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@wester130 right, it doesn't raise NO itself. PDE5 is the enzyme that breaks down the cGMP that NO produces, so blocking it makes the effect of the NO you already have last longer. Ray Peat counted Viagra as one of those NO drugs. In The dark side of stress he wrote that "drugs that are intended to increase the effects of nitric oxide (asparagine, zildenafil/Viagra, minoxidil/Rogaine) and acetylcholine (bethanechol, benzpyrinium, etc.) should be avoided." Cialis blocks the same enzyme, so I'd guess he'd have put it on that list too.
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@thebiooracle no different to cocoa, pomegranate juice or even caffeine
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