Is Cialis/Tadalafil Harmful?
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I started taking 2.5mg recently. No noticeable side effects.
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I think tadalafil, when used daily in the lower doses (like 2.5 to 5mg) is fairly safe and beneficial. Most of the side effects of tadalifil come from people taking large doses, usually more "on demand" than daily. Tadalafil first came to market in 2004, meaning it has been out for more than 20 years, a number that Ray Peat suggested was a minimum for considering a drug.
There have actually been quite a number of positives reported from longer term use, both anecdotally, and from studies. Some studies have noted that tadalafil and sildenafil seem to be associated with longer lifespans than those who don't take the drugs. Doesn't seem like they increase aging, as one commenter above suggested. Tadalafil does not increase NO, and seems to lower estrogen and increase testosterone.
There was even this case study, which suggests that tadalafil helped to heal a chronic wound in about 2 months-
https://pmc.ncbi.nlm.nih.gov/articles/PMC7950937/Having said all that, I have been willing recently to personally experiment with tadalafil, in the lower daily doses, and have noted mostly positives, with no side effects to speak of. I wouldn't consider it "Peaty" necessarily, but I don't see any major objections that Dr. Peat would have had, based on what I now know about the drug. It seems similar, in some ways, to losartan. Both can lower BP, both can relax blood vessels, and both can help increase erections (due to improved blood flow), and both seem to have some anti inflammatory properties.
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@ZackVegas ever considered black ginger?
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@ZackVegas this is extraordinary
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Makes my sinuses congested which I assume means it is doing something bad systemically. Also weird vision side effects (Blue tint) probably not good. If you have ED take pregnenolone+DHEA, or just low dose topical DHEA. Will help.
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@jimmynelson what doses were used? low dose 2mg looks okay
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@wester130 I have no opinion on this as I've never gone above 5mg.
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Makes my sinuses congested which I assume means it is doing something bad systemically.
The sinus congestion is a known side effect, and it's thought to be due to the main effect of tadalifil, which is relaxing blood vessels, and increasing blood flow. Headaches are also commonly reported as a side, and these are also thought to be due to main effect of relaxing blood vessels. Many report than these side effects die down or go away over time with continued use.
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low nitric oxide can be bad
however Cialis does not raise nitric oxide directly
https://lowtoxinforum.com/threads/warning-to-people-taking-lysine.22864/
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@wester130 right, it doesn't raise NO itself. PDE5 is the enzyme that breaks down the cGMP that NO produces, so blocking it makes the effect of the NO you already have last longer. Ray Peat counted Viagra as one of those NO drugs. In The dark side of stress he wrote that "drugs that are intended to increase the effects of nitric oxide (asparagine, zildenafil/Viagra, minoxidil/Rogaine) and acetylcholine (bethanechol, benzpyrinium, etc.) should be avoided." Cialis blocks the same enzyme, so I'd guess he'd have put it on that list too.
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@thebiooracle no different to cocoa, pomegranate juice or even caffeine
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